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Year Number of Results
1968 2
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1984 2
1986 4
1988 2
1990 1
1991 4
1992 5
1994 3
1995 4
1996 7
1997 2
1998 2
1999 5
2000 5
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2002 2
2003 8
2004 9
2005 12
2006 12
2007 10
2008 11
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2023 45
2024 14

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534 results

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Page 1
A Fischer-Type Ruthenium Carbene Complex as a Metathesis Catalyst for the Synthesis of Enol Ethers.
Wang XL, Chiang NY, Peng JJ, Yu L, Xu LJ, Yang HR, Jin BY, Zhang P, Lai YY, Li Z, Lai GQ, Luh TY. Wang XL, et al. J Org Chem. 2021 Dec 17;86(24):17629-17639. doi: 10.1021/acs.joc.1c01741. Epub 2021 Nov 30. J Org Chem. 2021. PMID: 34846148
In addition to vinyl ethers, vinylic esters can also be used. The time required to reach a 50% yield of the ROCM product t(50) varies from 0.01 to 140 h depending on the strain and nucleophilicity of the double bond. ...
In addition to vinyl ethers, vinylic esters can also be used. The time required to reach a 50% yield of the ROCM product t(50) varies …
Total Synthesis of (-)-Enigmazole B.
Goda Y, Fuwa H. Goda Y, et al. Org Lett. 2023 Dec 1;25(47):8402-8407. doi: 10.1021/acs.orglett.3c03002. Epub 2023 Oct 5. Org Lett. 2023. PMID: 37796572
Total synthesis of (-)-enigmazole B was achieved for the first time. Highlights of the present synthesis include an olefin cross-metathesis and hemiacetalization/intramolecular oxa-Michael addition sequence for accessing an (E)-configured enol tosylate, a Sonogashir …
Total synthesis of (-)-enigmazole B was achieved for the first time. Highlights of the present synthesis include an olefin cross-meta …
Biosynthesis of kratom opioids.
Kim K, Shahsavarani M, Garza-García JJO, Carlisle JE, Guo J, De Luca V, Qu Y. Kim K, et al. New Phytol. 2023 Oct;240(2):757-769. doi: 10.1111/nph.19162. Epub 2023 Jul 30. New Phytol. 2023. PMID: 37518950
Our investigations led to the identification of several reductases and an enol methyltransferase that forms a new clade within the SABATH methyltransferase family. ...Through these breakthroughs, we achieved the microbial biosynthesis of kratom opioids for the first tim …
Our investigations led to the identification of several reductases and an enol methyltransferase that forms a new clade within the SA …
The Surprising Dynamics of the McLafferty Rearrangement.
Stamm J, Kwon S, Sandhu S, Shaik M, Das R, Sandhu J, Curenton B, Wicka C, Levine BG, Sun L, Dantus M. Stamm J, et al. J Phys Chem Lett. 2023 Nov 9;14(44):10088-10093. doi: 10.1021/acs.jpclett.3c02102. Epub 2023 Nov 2. J Phys Chem Lett. 2023. PMID: 37917859
We report femtosecond time-resolved measurements of the McLafferty rearrangement following the strong-field tunnel ionization of 2-pentanone, 4-methyl-2-pentanone, and 4,4-dimethyl-2-pentanone. ...Following nearly instantaneous ionization, the fast time scale is ass …
We report femtosecond time-resolved measurements of the McLafferty rearrangement following the strong-field tunnel ionization of 2-pe …
Ultrafast Charge Relocation Dynamics in Enol-Keto Tautomerization Monitored with a Local Soft-X-ray Probe.
Soley MB, Videla PE, Nibbering ETJ, Batista VS. Soley MB, et al. J Phys Chem Lett. 2022 Sep 8;13(35):8254-8263. doi: 10.1021/acs.jpclett.2c02037. Epub 2022 Aug 26. J Phys Chem Lett. 2022. PMID: 36018775 Free PMC article.
The interplay of proton and electronic charge distribution motions can vary from sequential to concerted schemes, with elementary steps occurring on ultrafast time scales. We demonstrate with a simulation study that femtosecond soft-X-ray spectroscopy provides key insights …
The interplay of proton and electronic charge distribution motions can vary from sequential to concerted schemes, with elementary steps occu …
Synthesis of interstellar propen-2-ol (CH(3)C(OH)CH(2)) - the simplest enol tautomer of a ketone.
Wang J, Nikolayev AA, Zhang C, Marks JH, Azyazov VN, Eckhardt AK, Mebel AM, Kaiser RI. Wang J, et al. Phys Chem Chem Phys. 2023 Jul 5;25(26):17460-17469. doi: 10.1039/d3cp02307a. Phys Chem Chem Phys. 2023. PMID: 37357555
Here we present a combined experimental and computational study demonstrating the first preparation of propen-2-ol (CH(3)C(OH)CH(2)) and its isomer methyl vinyl ether (CH(3)OCHCH(2)) in low-temperature acetone (CH(3)COCH(3)) ices upon exposure to energetic electrons. Propen-2-ol …
Here we present a combined experimental and computational study demonstrating the first preparation of propen-2-ol (CH(3)C(OH)CH(2)) and its …
DNA Polymerase lambda Active Site Favors a Mutagenic Mispair between the Enol Form of Deoxyguanosine Triphosphate Substrate and the Keto Form of Thymidine Template: A Free Energy Perturbation Study.
Maximoff SN, Kamerlin SCL, Florián J. Maximoff SN, et al. J Phys Chem B. 2017 Aug 24;121(33):7813-7822. doi: 10.1021/acs.jpcb.7b04874. Epub 2017 Aug 14. J Phys Chem B. 2017. PMID: 28732447
Hence, there is an intriguing possibility that either thymine in the DNA or guanine in the deoxyguanosine triphosphate analogue may spend a substantial fraction of time in a deprotonated or enol form (both are minor species in aqueous solution) in the active site of …
Hence, there is an intriguing possibility that either thymine in the DNA or guanine in the deoxyguanosine triphosphate analogue may spend a …
Elusive Dehydroalanine Derivatives with Enhanced Reactivity.
Aydillo C, Mazo N, Navo CD, Jiménez-Osés G. Aydillo C, et al. Chembiochem. 2019 May 15;20(10):1246-1250. doi: 10.1002/cbic.201800758. Epub 2019 Apr 1. Chembiochem. 2019. PMID: 30650254
For the first time, a simple methodology for the chemical synthesis and use of highly reactive 4-methylenoxazol-5(4H)-ones from serine is presented. These dehydroalanine derivatives, which resemble the natural 4-methylidenimidazole-5-one (MIO) cofactor present in lyases an …
For the first time, a simple methodology for the chemical synthesis and use of highly reactive 4-methylenoxazol-5(4H)-ones from serin …
Ultrafast excited state dynamics of nonfluorescent cyclopheophorbide-a enol, a catabolite of chlorophyll-a detoxified in algae-feeding aquatic microbes.
Ota C, Sugihara K, Kinoshita Y, Kashiyama Y, Nagasawa Y, Tamiaki H. Ota C, et al. Photochem Photobiol Sci. 2019 Jan 1;18(1):64-70. doi: 10.1039/c8pp00173a. Epub 2018 Oct 9. Photochem Photobiol Sci. 2019. PMID: 30298893
Recently, it has been reported that the metabolic conversion of Chls-a/b to 13(2),17(3)-cyclopheophorbide-a/b enols (cPPB-a/bEs) is the detoxification mechanism for algivorous protists. cPPB-a/bEs are colored pi-conjugated cyclic tetrapyrroles but are nonfluorescent due to effici …
Recently, it has been reported that the metabolic conversion of Chls-a/b to 13(2),17(3)-cyclopheophorbide-a/b enols (cPPB-a/bEs) is the deto …
534 results