Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development.
Tagliatti E, Desiato G, Mancinelli S, Bizzotto M, Gagliani MC, Faggiani E, Hernández-Soto R, Cugurra A, Poliseno P, Miotto M, Argüello RJ, Filipello F, Cortese K, Morini R, Lodato S, Matteoli M.
Tagliatti E, et al.
Immunity. 2024 Jan 9;57(1):86-105.e9. doi: 10.1016/j.immuni.2023.12.002. Epub 2023 Dec 29.
Immunity. 2024.
PMID: 38159572
Free PMC article.
In the absence of Trem2, developing neurons in the hippocampal cornus ammonis (CA)1 but not in CA3 subfield displayed compromised energetic metabolism, accompanied by reduced mitochondrial mass and abnormal organelle ultrastructure. This was paralleled by the transcription …
In the absence of Trem2, developing neurons in the hippocampal cornus ammonis (CA)1 but not in CA3 subfield displayed compromised energetic …