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A quantile frailty index without dichotomization.
Stubbings G, Rockwood K, Mitnitski A, Rutenberg A. Stubbings G, et al. Mech Ageing Dev. 2021 Oct;199:111570. doi: 10.1016/j.mad.2021.111570. Epub 2021 Sep 10. Mech Ageing Dev. 2021. PMID: 34517019
We show that the QFI outperforms previous frailty index (FI) measures on cross-sectional laboratory data (NHANES, CSHA, and ELSA). We construct the QFI by ranking the risk of individuals with respect to a reference population. ...
We show that the QFI outperforms previous frailty index (FI) measures on cross-sectional laboratory data (NHANES, CSHA, and ELSA). We …
A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss.
Nolan LS, Cadge BA, Gomez-Dorado M, Dawson SJ. Nolan LS, et al. Mech Ageing Dev. 2013 Jul-Aug;134(7-8):298-306. doi: 10.1016/j.mad.2013.02.009. Epub 2013 Mar 13. Mech Ageing Dev. 2013. PMID: 23500038 Clinical Trial.
Variants with effects on transcription factor binding were then tested in association studies in discovery and replication cohorts (London ARHL and ELSA cohorts, n=2177). RESULTS: The rs5746092 (-38C>G) and rs2758343 (-299C>A) SNPs alter the affinity of the SOD2 prom …
Variants with effects on transcription factor binding were then tested in association studies in discovery and replication cohorts (London A …