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Page 1
Dissecting the Interaction of FGF8 with Receptor FGFRL1.
Zhuang L, Vogel M, Villiger PM, Trueb B. Zhuang L, et al. Biomolecules. 2020 Oct 1;10(10):1399. doi: 10.3390/biom10101399. Biomolecules. 2020. PMID: 33019532 Free PMC article.
All polypeptides that contain the Ig2 domain (Ig123, Ig12, Ig23, Ig2) were found to interact with FGF8 with very high affinity, whereas all constructs that lack the Ig2 domain (Ig1, Ig3, Ig13) poorly interacted with FGF8 as shown by ELISA and surface plasmon resonance. It …
All polypeptides that contain the Ig2 domain (Ig123, Ig12, Ig23, Ig2) were found to interact with FGF8 with very high affinity, whereas all …
Accuracy of serological testing for SARS-CoV-2 antibodies: First results of a large mixed-method evaluation study.
Brigger D, Horn MP, Pennington LF, Powell AE, Siegrist D, Weber B, Engler O, Piezzi V, Damonti L, Iseli P, Hauser C, Froehlich TK, Villiger PM, Bachmann MF, Leib SL, Bittel P, Fiedler M, Largiadèr CR, Marschall J, Stalder H, Kim PS, Jardetzky TS, Eggel A, Nagler M. Brigger D, et al. Allergy. 2021 Mar;76(3):853-865. doi: 10.1111/all.14608. Epub 2020 Nov 13. Allergy. 2021. PMID: 32997812 Free PMC article.
METHODS: Consecutive patients admitted with confirmed SARS-CoV-2 infection were prospectively followed alongside medical staff and biobank samples from winter 2018/2019. An in-house enzyme-linked immunosorbent assay utilizing recombinant receptor-bindi …
METHODS: Consecutive patients admitted with confirmed SARS-CoV-2 infection were prospectively followed alongside medical staff and biobank s …
Safety and immunogenicity of tetanus/diphtheria vaccination in patients with rheumatic diseases-a prospective multi-centre cohort study.
Bühler S, Jaeger VK, Adler S, Bannert B, Brümmerhoff C, Ciurea A, Distler O, Franz J, Gabay C, Hagenbuch N, Herzog C, Hasler P, Kling K, Kyburz D, Müller R, Nissen MJ, Siegrist CA, Villiger PM, Walker UA, Hatz C. Bühler S, et al. Rheumatology (Oxford). 2019 Sep 1;58(9):1585-1596. doi: 10.1093/rheumatology/kez045. Rheumatology (Oxford). 2019. PMID: 30877773 Clinical Trial.
Antibody concentrations against vaccine antigens were measured by ELISA. Immunogenicity was compared between patient and medication groups. ...
Antibody concentrations against vaccine antigens were measured by ELISA. Immunogenicity was compared between patient and medication g …
Pregnancy in patients with rheumatic disease: anti-inflammatory cytokines increase in pregnancy and decrease post partum.
Østensen M, Förger F, Nelson JL, Schuhmacher A, Hebisch G, Villiger PM. Østensen M, et al. Ann Rheum Dis. 2005 Jun;64(6):839-44. doi: 10.1136/ard.2004.029538. Epub 2004 Nov 11. Ann Rheum Dis. 2005. PMID: 15539410 Free PMC article.
METHODS: Plasma and serum samples of 34 pregnant patients, 19 with RA, 6 with JIA, and 9 with AS, and of 30 healthy pregnant women, 20 non-pregnant patients, and 10 non-pregnant healthy women were analysed for levels of interferon gamma (IFNgamma), interleukin (IL) 1beta, IL10, I …
METHODS: Plasma and serum samples of 34 pregnant patients, 19 with RA, 6 with JIA, and 9 with AS, and of 30 healthy pregnant women, 20 non-p …
Detection of latent tuberculosis in immunosuppressed patients with autoimmune diseases: performance of a Mycobacterium tuberculosis antigen-specific interferon gamma assay.
Matulis G, Jüni P, Villiger PM, Gadola SD. Matulis G, et al. Ann Rheum Dis. 2008 Jan;67(1):84-90. doi: 10.1136/ard.2007.070789. Epub 2007 Jul 20. Ann Rheum Dis. 2008. PMID: 17644549
Agreement between the IFNgamma assay and TST results was low (kappa = 0.17; 95% CI 0.02 to 0.32). The odds for a positive IFNgamma assay strongly increased with increasing prognostic relevance of LTBI risk factors. ...
Agreement between the IFNgamma assay and TST results was low (kappa = 0.17; 95% CI 0.02 to 0.32). The odds for a positive IFNgamma …
The physiologic increase in expression of some type I IFN-inducible genes during pregnancy is not associated with improved disease activity in pregnant patients with rheumatoid arthritis.
Weix J, Häupl T, Raio L, Villiger PM, Förger F. Weix J, et al. Transl Res. 2013 Jun;161(6):505-12. doi: 10.1016/j.trsl.2013.02.007. Epub 2013 Mar 16. Transl Res. 2013. PMID: 23507374
IFN-alpha and IFN-beta levels in sera of patients and healthy donors were analyzed by enzyme linked immunosorbent assay. It was found that healthy women did not show a change of gene expression levels from the second trimester until postpartum, yet som …
IFN-alpha and IFN-beta levels in sera of patients and healthy donors were analyzed by enzyme linked immunosorbent as …
Pretreatment cytokine profiles of peripheral blood mononuclear cells and serum from patients with rheumatoid arthritis in different american college of rheumatology response groups to methotrexate.
Seitz M, Zwicker M, Villiger PM. Seitz M, et al. J Rheumatol. 2003 Jan;30(1):28-35. J Rheumatol. 2003. PMID: 12508386
PBMC were cultured 2 days under resting conditions, and interleukin 1 receptor antagonist (IL-1ra), IL-1beta, soluble tumor necrosis factor receptor p55+75 (sTNFR p55+p75), and TNF-a release into cell culture supernatants and corresponding serum cytokine levels were determined by …
PBMC were cultured 2 days under resting conditions, and interleukin 1 receptor antagonist (IL-1ra), IL-1beta, soluble tumor necrosis factor …