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The Releasate of Avascular Cartilage Demonstrates Inherent Pro-Angiogenic Properties In Vitro and In Vivo.
Nossin Y, Farrell E, Koevoet WJLM, Datema F, Somoza RA, Caplan AI, van Osch GJVM. Nossin Y, et al. Cartilage. 2021 Dec;13(2_suppl):559S-570S. doi: 10.1177/19476035211047628. Epub 2021 Sep 30. Cartilage. 2021. PMID: 34590881 Free PMC article.
Experiments were done with triplicate samples of cartilage from 3 different donors. RESULTS: RNAseq data of 3 healthy human articular cartilage donors revealed that the majority of known angiogenesis-related factors expressed in healthy adult articular cartilage are …
Experiments were done with triplicate samples of cartilage from 3 different donors. RESULTS: RNAseq data of 3 healthy human articular …
The Habitat Assay, a Platform to Study In Vivo Properties of Human Mesenchymal Stem Cells.
Lennon DP, Somoza RA, Schluchter MA, Caplan AI. Lennon DP, et al. Tissue Eng Part A. 2020 Dec;26(23-24):1378-1387. doi: 10.1089/ten.TEA.2020.0178. Epub 2020 Nov 26. Tissue Eng Part A. 2020. PMID: 33107389 Free PMC article.
These donor-derived hMSCs form bone structures by 3-4 weeks and associate as perivascular MSCs. ...These studies show that passage number and the age of the hMSC donor influence the sequence of in vivo bone formation within the Habitat. ...
These donor-derived hMSCs form bone structures by 3-4 weeks and associate as perivascular MSCs. ...These studies show that passage nu …
Luminescent core-shell imprinted nanoparticles engineered for targeted Förster resonance energy transfer-based sensing.
Descalzo AB, Somoza C, Moreno-Bondi MC, Orellana G. Descalzo AB, et al. Anal Chem. 2013 Jun 4;85(11):5316-20. doi: 10.1021/ac400520s. Epub 2013 May 16. Anal Chem. 2013. PMID: 23675738
Ru(phen)32+ dye molecules embedded off-center in the silica core provide the long-lived donor emission, and a near-infrared labeled analyte serves as fluorescent acceptor (the measured R0 of this D-A pair is 4.3 nm). ...
Ru(phen)32+ dye molecules embedded off-center in the silica core provide the long-lived donor emission, and a near-infrared labeled a …
Beta-cell function abnormalities in islets from an adult subject with nesidioblastosis and autoantibodies against the islet cells.
Conget I, Sarri Y, Somoza N, Vives M, Novials A, Ariza A, Fernández-Alvarez J, Pujol-Borrell R, Gomis R. Conget I, et al. Pancreas. 1997 Jan;14(1):71-5. doi: 10.1097/00006676-199701000-00011. Pancreas. 1997. PMID: 8981510
Isolated nesidioblastotic islets showed an increased basal rate of insulin secretion (nesidioblastotic islets, 81.3 +/- 6.4 vs. control islets, from cadaveric organ normal donors, 10.2 +/- 0.9 microU/islet/90 min) without any further release with increasing glucose concent …
Isolated nesidioblastotic islets showed an increased basal rate of insulin secretion (nesidioblastotic islets, 81.3 +/- 6.4 vs. control isle …
Endotoxin contamination may be responsible for the unexplained failure of human pancreatic islet transplantation.
Vargas F, Vives-Pi M, Somoza N, Armengol P, Alcalde L, Martí M, Costa M, Serradell L, Dominguez O, Fernández-Llamazares J, Julian JF, Sanmartí A, Pujol-Borrell R. Vargas F, et al. Transplantation. 1998 Mar 15;65(5):722-7. doi: 10.1097/00007890-199803150-00020. Transplantation. 1998. PMID: 9521209
We report here the identification of a possible causative factor: endotoxin present in the collagenase preparations used to disperse the pancreatic tissue before islet purification and transplantation. Supporting evidence includes (1) detection of unexpectedly high levels …
We report here the identification of a possible causative factor: endotoxin present in the collagenase preparations used to disperse the pan …