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Functional characterization of hepatocyte nuclear factor-4 alpha dimerization interface mutants.
Aggelidou E, Iordanidou P, Demetriades C, Piltsi O, Hadzopoulou-Cladaras M. Aggelidou E, et al. FEBS J. 2006 May;273(9):1948-58. doi: 10.1111/j.1742-4658.2006.05208.x. FEBS J. 2006. PMID: 16640558 Free article.
Dimerization controls important aspects of receptor function, such as DNA binding, protein stability, ligand binding and interaction with coactivators. Crystallographic data of the HNF-4alpha ligand-binding domain (LBD) demonstrated that the homodimer interface is c …
Dimerization controls important aspects of receptor function, such as DNA binding, protein stability, ligand binding and interaction …
Critical role of residues defining the ligand binding pocket in hepatocyte nuclear factor-4alpha.
Aggelidou E, Iordanidou P, Tsantili P, Papadopoulos G, Hadzopoulou-Cladaras M. Aggelidou E, et al. J Biol Chem. 2004 Jul 16;279(29):30680-8. doi: 10.1074/jbc.M401120200. Epub 2004 Apr 30. J Biol Chem. 2004. PMID: 15123688 Free article.
Our results show the importance of residues Ser-181, Met-182 in H3, Leu-219, Leu-220 and Arg-226 in H5, Ile-338 in H10, and Ile-346 in H11 that line the ligand-binding domain pocket in HNF-4alpha and impair its transactivation potential. ...
Our results show the importance of residues Ser-181, Met-182 in H3, Leu-219, Leu-220 and Arg-226 in H5, Ile-338 in H10, and Ile-346 in H11 t …
A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion.
Murphy JJ, Hobby P, Vilarino-Varela J, Bishop B, Iordanidou P, Sutton BJ, Norton JD. Murphy JJ, et al. Biochem J. 2002 Feb 1;361(Pt 3):431-6. doi: 10.1042/0264-6021:3610431. Biochem J. 2002. PMID: 11802771 Free PMC article.
A novel lymphocyte-specific immunoglobulin superfamily protein (19A) has been cloned. The predicted 335-amino-acid sequence of 19A represents a Type 1 membrane protein with homology with the CD2 family of receptors. A molecular model of the two predicted extracellul …
A novel lymphocyte-specific immunoglobulin superfamily protein (19A) has been cloned. The predicted 335-amino-acid sequence of 19A re …
Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha.
Iordanidou P, Aggelidou E, Demetriades C, Hadzopoulou-Cladaras M. Iordanidou P, et al. J Biol Chem. 2005 Jun 10;280(23):21810-9. doi: 10.1074/jbc.M501221200. Epub 2005 Apr 12. J Biol Chem. 2005. PMID: 15826954 Free article.
Crystallographic analysis of the HNF-4alpha and HNF-4gamma ligand binding domains (LBDs) demonstrated the presence of endogenous ligands that may act as structural cofactors for HNF-4. ...In the present study, physical and functional interaction assays were utilized with t …
Crystallographic analysis of the HNF-4alpha and HNF-4gamma ligand binding domains (LBDs) demonstrated the presence of endogenous liga …