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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1982 2
1984 1
1985 2
1986 1
1987 1
1988 1
1989 1
1990 2
1991 6
1992 4
1993 3
1994 3
1995 8
1996 12
1997 15
1998 10
1999 20
2000 16
2001 23
2002 15
2003 13
2004 19
2005 19
2006 16
2007 15
2008 22
2009 16
2010 18
2011 21
2012 17
2013 19
2014 20
2015 11
2016 8
2017 12
2018 7
2019 13
2020 16
2021 13
2022 12
2023 8
2024 2

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429 results

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Page 1
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Sc… See abstract for full author list ➔ Malik R, et al. Nat Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3. Epub 2018 Mar 12. Nat Genet. 2018. PMID: 29531354 Free PMC article.
We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. ...
We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism …
Circulating tumor DNA-guided treatment with pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer: a phase 2 trial.
Nakamura Y, Okamoto W, Kato T, Esaki T, Kato K, Komatsu Y, Yuki S, Masuishi T, Nishina T, Ebi H, Sawada K, Taniguchi H, Fuse N, Nomura S, Fukui M, Matsuda S, Sakamoto Y, Uchigata H, Kitajima K, Kuramoto N, Asakawa T, Olsen S, Odegaard JI, Sato A, Fujii S, Ohtsu A, Yoshino T. Nakamura Y, et al. Nat Med. 2021 Nov;27(11):1899-1903. doi: 10.1038/s41591-021-01553-w. Epub 2021 Nov 11. Nat Med. 2021. PMID: 34764486 Free PMC article. Clinical Trial.
The applicability of circulating tumor DNA (ctDNA) genotyping to inform enrollment of patients with cancer in clinical trials has not been established. ...
The applicability of circulating tumor DNA (ctDNA) genotyping to inform enrollment of patients with cancer in clinical trials has not …
A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity.
Matsuda K, Migueles SA, Huang J, Bolkhovitinov L, Stuccio S, Griesman T, Pullano AA, Kang BH, Ishida E, Zimmerman M, Kashyap N, Martins KM, Stadlbauer D, Pederson J, Patamawenu A, Wright N, Shofner T, Evans S, Liang CJ, Candia J, Biancotto A, Fantoni G, Poole A, Smith J, Alexander J, Gurwith M, Krammer F, Connors M. Matsuda K, et al. J Clin Invest. 2021 Mar 1;131(5):e140794. doi: 10.1172/JCI140794. J Clin Invest. 2021. PMID: 33529172 Free PMC article. Clinical Trial.
Serum antibodies were measured by a pseudovirus entry inhibition, microneutralization, and HA inhibition assays.RESULTSAd4-H5-Vtn DNA was shed from most upper respiratory tract-immunized (URT-immunized) volunteers for 2 to 4 weeks, but cultured from only 60% of participant …
Serum antibodies were measured by a pseudovirus entry inhibition, microneutralization, and HA inhibition assays.RESULTSAd4-H5-Vtn DNA …
Crystal structures of DNA:DNA and DNA:RNA duplexes containing 5-(N-aminohexyl)carbamoyl-modified uracils reveal the basis for properties as antigene and antisense molecules.
Juan EC, Kondo J, Kurihara T, Ito T, Ueno Y, Matsuda A, Takénaka A. Juan EC, et al. Nucleic Acids Res. 2007;35(6):1969-77. doi: 10.1093/nar/gkl821. Epub 2007 Mar 6. Nucleic Acids Res. 2007. PMID: 17341465 Free PMC article.
Relative to unmodified DNA, oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2'-deoxyuridine ((N)U) or 5-(N-aminohexyl)carbamoyl-2'-O-methyluridine ((N)U(m)), respectively exhibit increased binding affinity for DNA and RNA, and enhan …
Relative to unmodified DNA, oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2'-deoxyuridine ((N)U) or 5-(N …
HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence.
Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S. Cui M, et al. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2306454120. doi: 10.1073/pnas.2306454120. Epub 2024 Jan 3. Proc Natl Acad Sci U S A. 2024. PMID: 38170752
Interestingly, HKDC1 regulated mitophagy and lysosomal repair independently of its prospective function in glycolysis. Furthermore, loss function of HKDC1 accelerated DNA damage-induced cellular senescence with the accumulation of hyperfused mitochondria and damaged lysoso …
Interestingly, HKDC1 regulated mitophagy and lysosomal repair independently of its prospective function in glycolysis. Furthermore, loss fun …
Unique B-1 cells specific for both N-pyrrolated proteins and DNA evolve with apolipoprotein E deficiency.
Lim SY, Yamaguchi K, Itakura M, Chikazawa M, Matsuda T, Uchida K. Lim SY, et al. J Biol Chem. 2022 Feb;298(2):101582. doi: 10.1016/j.jbc.2022.101582. Epub 2022 Jan 11. J Biol Chem. 2022. PMID: 35031322 Free PMC article.
Lysine N-pyrrolation, a posttranslational modification, which converts lysine residues to N(epsilon)-pyrrole-L-lysine, imparts electronegative properties to proteins, causing them to mimic DNA. ...Finally, we report that a subset of monoclonal IgM antibodies …
Lysine N-pyrrolation, a posttranslational modification, which converts lysine residues to N(epsilon)-pyrrole-L-lysine, imparts …
Increased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol.
Nagayoshi H, Matsumoto A, Nishi R, Kawamoto T, Ichiba M, Matsuda T. Nagayoshi H, et al. Mutat Res. 2009 Feb 19;673(1):74-7. doi: 10.1016/j.mrgentox.2008.11.009. Epub 2008 Dec 3. Mutat Res. 2009. PMID: 19101651
We analyzed an acetaldehyde-derived DNA adduct, N(2)-ethylidene-2'-deoxyguanosine (N(2)-Eti-dG) in stomach DNA of aldehyde dehydrogenase (Aldh)-2-knockout mice that were fed with alcohol to determine effects of alcohol consumption and Aldh2 genotype on …
We analyzed an acetaldehyde-derived DNA adduct, N(2)-ethylidene-2'-deoxyguanosine (N(2)-Eti-dG) in stomach DNA o …
DNA Adductome Analysis Identifies N-Nitrosopiperidine Involved in the Etiology of Esophageal Cancer in Cixian, China.
Totsuka Y, Lin Y, He Y, Ishino K, Sato H, Kato M, Nagai M, Elzawahry A, Totoki Y, Nakamura H, Hosoda F, Shibata T, Matsuda T, Matsushima Y, Song G, Meng F, Li D, Liu J, Qiao Y, Wei W, Inoue M, Kikuchi S, Nakagama H, Shan B. Totsuka Y, et al. Chem Res Toxicol. 2019 Aug 19;32(8):1515-1527. doi: 10.1021/acs.chemrestox.9b00017. Epub 2019 Jul 9. Chem Res Toxicol. 2019. PMID: 31286759
N(2)-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)deoxyguanosine (THP-dG) was the major adduct detected in samples from esophageal cancer patients in Cixian. The precursor of THP-dG, N-nitrosopiperidine (NPIP), exhibited a strong mutagenic activity under metabolic activation i …
N(2)-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)deoxyguanosine (THP-dG) was the major adduct detected in samples from esophageal cancer patien …
Studying progression from glucose intolerance to type 2 diabetes in obese children.
Dubinina IA, Chistiakov DA, Eremina IA, Brovkin AN, Zilberman LI, Nikitin AG, Kuraeva TL, Nosikov VV, Peterkova VA, Dedov II. Dubinina IA, et al. Diabetes Metab Syndr. 2014 Jul-Sep;8(3):133-7. doi: 10.1016/j.dsx.2014.07.002. Epub 2014 Aug 7. Diabetes Metab Syndr. 2014. PMID: 25127329 Review.
PATIENTS AND METHODS: Three groups of obese children with NGT (n=54), IGT (n=35), and T2D (n=62) were evaluated. A control group of non-obese normal children (n=210) was also studied. ...Insulin resistance (IR) was assessed using HOMA-IR index. Insulin …
PATIENTS AND METHODS: Three groups of obese children with NGT (n=54), IGT (n=35), and T2D (n=62) were evaluated. A cont …
Mechanism-Based Inhibitor of DNA Cytosine-5 Methyltransferase by a S(N) Ar Reaction with an Oligodeoxyribonucleotide Containing a 2-Amino-4-Halopyridine-C-Nucleoside.
Sato K, Kunitomo Y, Kasai Y, Utsumi S, Suetake I, Tajima S, Ichikawa S, Matsuda A. Sato K, et al. Chembiochem. 2018 Apr 16;19(8):865-872. doi: 10.1002/cbic.201700688. Epub 2018 Mar 14. Chembiochem. 2018. PMID: 29392812
In chromatin, 5-methylcytosine (mC), which represents the fifth nucleobase in genomic DNA, plays a role as an inducer of epigenetic changes. Tumor cells exhibit aberrant DNA methylation patterns, and inhibition of human DNA cytosine-5 methyltransferase (DNMT) …
In chromatin, 5-methylcytosine (mC), which represents the fifth nucleobase in genomic DNA, plays a role as an inducer of epigenetic c …
429 results