Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.
Zeniou M, Fève M, Mameri S, Dong J, Salomé C, Chen W, El-Habr EA, Bousson F, Sy M, Obszynski J, Boh A, Villa P, Assad Kahn S, Didier B, Bagnard D, Junier MP, Chneiweiss H, Haiech J, Hibert M, Kilhoffer MC.
Zeniou M, et al.
PLoS One. 2015 Aug 13;10(8):e0134793. doi: 10.1371/journal.pone.0134793. eCollection 2015.
PLoS One. 2015.
PMID: 26270679
Free PMC article.
Twenty active molecules belonging to different pharmacological classes have thus been identified. Among those, the stimulant laxative drug bisacodyl was the sole to inhibit in a potent and specific manner the survival of quiescent glioblastoma stem-like cells. ...
Twenty active molecules belonging to different pharmacological classes have thus been identified. Among those, the stimulant laxative …