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Did you mean de xing zhang (33 results)?
The neuroprotective effect of dexmedetomidine and its mechanism.
Hu Y, Zhou H, Zhang H, Sui Y, Zhang Z, Zou Y, Li K, Zhao Y, Xie J, Zhang L. Hu Y, et al. Front Pharmacol. 2022 Sep 20;13:965661. doi: 10.3389/fphar.2022.965661. eCollection 2022. Front Pharmacol. 2022. PMID: 36204225 Free PMC article. Review.
Dexmedetomidine (DEX) is a highly selective alpha2 receptor agonist that is routinely used in the clinic for sedation and anesthesia. ...Therefore, DEX can provide a crucial advantage in neurological recovery for patients with brain injury. ...
Dexmedetomidine (DEX) is a highly selective alpha2 receptor agonist that is routinely used in the clinic for sedation and anesthesia. …
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
Guo Q, Ma M, Yu H, Han Y, Zhang D. Guo Q, et al. Ann Med. 2023 Dec;55(1):2209735. doi: 10.1080/07853890.2023.2209735. Ann Med. 2023. PMID: 37162502 Free PMC article.
Focusing on cuproptosis, the mechanism of DEX in the I/R was revealed. Using the I/R rat model, the effects of DEX and the copper chelator D-penicillamine on cerebral infarct volume, copper levels, mitochondrial respiration and membrane potential, GSH content, and e …
Focusing on cuproptosis, the mechanism of DEX in the I/R was revealed. Using the I/R rat model, the effects of DEX and the cop …
Effects of dexmedetomidine on perioperative stress, inflammation, and immune function: systematic review and meta-analysis.
Wang K, Wu M, Xu J, Wu C, Zhang B, Wang G, Ma D. Wang K, et al. Br J Anaesth. 2019 Dec;123(6):777-794. doi: 10.1016/j.bja.2019.07.027. Epub 2019 Oct 24. Br J Anaesth. 2019. PMID: 31668347 Free article.
BACKGROUND: Dexmedetomidine (DEX) is a highly selective alpha2 adrenoceptor agonist with broad pharmacological effects, including sedation, analgesia, anxiolysis, and sympathetic tone inhibition. ...RESULTS: Sixty-seven studies (including randomised controlled trials and e …
BACKGROUND: Dexmedetomidine (DEX) is a highly selective alpha2 adrenoceptor agonist with broad pharmacological effects, including sed …
Prebiotics-Encapsulated Probiotic Spores Regulate Gut Microbiota and Suppress Colon Cancer.
Zheng DW, Li RQ, An JX, Xie TQ, Han ZY, Xu R, Fang Y, Zhang XZ. Zheng DW, et al. Adv Mater. 2020 Nov;32(45):e2004529. doi: 10.1002/adma.202004529. Epub 2020 Oct 1. Adv Mater. 2020. PMID: 33006175
Through the host-guest chemistry between commercial Clostridium butyricum and chemically modified prebiotic dextran, prebiotics-encapsulated probiotic spores (spores-dex) are prepared. It is found that spores-dex can specifically enrich in colon cancers after oral a …
Through the host-guest chemistry between commercial Clostridium butyricum and chemically modified prebiotic dextran, prebiotics-encapsulated …
Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury.
Wang C, Yuan W, Hu A, Lin J, Xia Z, Yang CF, Li Y, Zhang Z. Wang C, et al. Mol Med Rep. 2020 Jul;22(1):175-184. doi: 10.3892/mmr.2020.11114. Epub 2020 May 4. Mol Med Rep. 2020. PMID: 32377745 Free PMC article.
Furthermore, the levels of MDA, 8-hydroxy-2'-deoxyguanosine and the inflammatory factors IL-6 and monocyte chemoattractant protein-1 were also significantly increased. It was demonstrated that treatment with Dex reverted or attenuated these changes (CLP + Dex vs. CL …
Furthermore, the levels of MDA, 8-hydroxy-2'-deoxyguanosine and the inflammatory factors IL-6 and monocyte chemoattractant protein-1 were al …
Dexmedetomidine Attenuates Ferroptosis-Mediated Renal Ischemia/Reperfusion Injury and Inflammation by Inhibiting ACSL4 via α2-AR.
Tao WH, Shan XS, Zhang JX, Liu HY, Wang BY, Wei X, Zhang M, Peng K, Ding J, Xu SX, Li LG, Hu JK, Meng XW, Ji FH. Tao WH, et al. Front Pharmacol. 2022 Jun 14;13:782466. doi: 10.3389/fphar.2022.782466. eCollection 2022. Front Pharmacol. 2022. PMID: 35873574 Free PMC article.
This study aimed to investigate the detailed molecular mechanism of Dex protects kidneys against I/R injury through inhibiting ferroptosis. ...In addition, ACSL4 overexpression abolishes Dex-mediated protective effects on OGD/R induced ferroptosis and inflammation i …
This study aimed to investigate the detailed molecular mechanism of Dex protects kidneys against I/R injury through inhibiting ferrop …
In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers.
Zhang J, Wang Y, Zhang S, You GX, Li PL, Wang Q, Yu WL, Hu T, Zhou H, Zhao L. Zhang J, et al. Artif Cells Nanomed Biotechnol. 2018;46(sup3):S133-S137. doi: 10.1080/21691401.2018.1489273. Epub 2019 Jan 8. Artif Cells Nanomed Biotechnol. 2018. PMID: 30618312
The development of hemoglobin-based oxygen carriers (HBOCs) is a persistent and urgent need in biomedicine. As a potential HBOCs, Dextran-hemoglobin (Dex-bHb) has been developed over the past years. The novel Dex-bHb, whose thiol group of Cys-93(beta) was reversibly …
The development of hemoglobin-based oxygen carriers (HBOCs) is a persistent and urgent need in biomedicine. As a potential HBOCs, Dextran-he …
Dexmedetomidine alleviates ferroptosis following hepatic ischemia-reperfusion injury by upregulating Nrf2/GPx4-dependent antioxidant responses.
Zhang Y, Wei H, Wang M, Yu Y, Gu M, Zhong H, Dong S. Zhang Y, et al. Biomed Pharmacother. 2023 Dec 31;169:115915. doi: 10.1016/j.biopha.2023.115915. Epub 2023 Nov 24. Biomed Pharmacother. 2023. PMID: 38000361 Free article.
Additionally, Dex increased the levels of GSH, an antioxidative stress marker, and GPX4 expression in HIRI mice. ...ML385 significantly inhibited Dex-promoted Nrf2 nuclear aggregation with Gpx4 protein expression, hindering the efficacy of Dex. ...
Additionally, Dex increased the levels of GSH, an antioxidative stress marker, and GPX4 expression in HIRI mice. ...ML385 significant …
Dexmedetomidine alleviates host ADHD-like behaviors by reshaping the gut microbiota and reducing gut-brain inflammation.
Xu X, Zhuo L, Zhang L, Peng H, Lyu Y, Sun H, Zhai Y, Luo D, Wang X, Li X, Li L, Zhang Y, Ma X, Wang Q, Li Y. Xu X, et al. Psychiatry Res. 2023 May;323:115172. doi: 10.1016/j.psychres.2023.115172. Epub 2023 Mar 20. Psychiatry Res. 2023. PMID: 36958092 Free article.
Treatment with alpha2-adrenergic agonists in patients with ADHD is becoming increasingly common. However, the therapeutic potential of DEX for the treatment of ADHD is unknown. Here, we evaluated the effect of DEX on ADHD-like behavior in spontaneously hypertensive …
Treatment with alpha2-adrenergic agonists in patients with ADHD is becoming increasingly common. However, the therapeutic potential of DE …
Dexmedetomidine attenuates sleep deprivation-induced inhibition of hippocampal neurogenesis via VEGF-VEGFR2 signaling and inhibits neuroinflammation.
Zhang S, Zhang Y, Zheng Y, Zhu S, Sun J, Deng Y, Wang Q, Zhai Q. Zhang S, et al. Biomed Pharmacother. 2023 Sep;165:115085. doi: 10.1016/j.biopha.2023.115085. Epub 2023 Jun 29. Biomed Pharmacother. 2023. PMID: 37392656 Free article.
Long periods of sleep deprivation (SD) have serious effects on health. While the alpha(2) adrenoceptor agonist dexmedetomidine (DEX) can improve sleep quality for patients who have insomnia, the effect of DEX on cognition and mechanisms after SD remains elusive. ... …
Long periods of sleep deprivation (SD) have serious effects on health. While the alpha(2) adrenoceptor agonist dexmedetomidine (DEX) …
1,329 results