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Page 1
Estimated sdLDL-C for predicting high-risk coronary plaque features in psoriasis: a prospective observational study.
Sorokin AV, Patel N, Li H, Hong CG, Sampson M, O'Hagan R, Florida EM, Teague HL, Playford MP, Chen MY, Mehta NN, Remaley AT. Sorokin AV, et al. Lipids Health Dis. 2023 Apr 27;22(1):55. doi: 10.1186/s12944-023-01819-x. Lipids Health Dis. 2023. PMID: 37106374 Free PMC article.
The extent to which cholesterol on LDL subfractions, such as small dense LDL-C (sdLDL-C), are associated with vulnerable coronary plaque characteristics in PSO remains elusive. ...
The extent to which cholesterol on LDL subfractions, such as small dense LDL-C (sdLDL-C), are associated with vulnerable coronary pla …
Association of oxidized ApoB and oxidized ApoA-I with high-risk coronary plaque features in cardiovascular disease.
Sorokin AV, Hong CG, Aponte AM, Florida EM, Tang J, Patel N, Baranova IN, Li H, Parel PM, Chen V, Wilson SR, Ongstad EL, Collén A, Playford MP, Eggerman TL, Chen MY, Kotani K, Bocharov AV, Remaley AT. Sorokin AV, et al. JCI Insight. 2023 Oct 23;8(20):e172893. doi: 10.1172/jci.insight.172893. JCI Insight. 2023. PMID: 37698922 Free PMC article.
RESULTS: Patients were predominantly White, overweight men (58.5%) on statin therapy (43.5%). Increase in LDL-C, ApoB, small dense LDL-C (P < 0.001 for all), triglycerides (P = 0.03), and lower HDL function were observed in the high oxLDL group. ...
RESULTS: Patients were predominantly White, overweight men (58.5%) on statin therapy (43.5%). Increase in LDL-C, ApoB, small dense LD …
Association Between Oxidation-Modified Lipoproteins and Coronary Plaque in Psoriasis.
Sorokin AV, Kotani K, Elnabawi YA, Dey AK, Sajja AP, Yamada S, Ueda M, Harrington CL, Baumer Y, Rodante JA, Gelfand JM, Chen MY, Joshi AA, Playford MP, Remaley AT, Mehta NN. Sorokin AV, et al. Circ Res. 2018 Nov 9;123(11):1244-1254. doi: 10.1161/CIRCRESAHA.118.313608. Circ Res. 2018. PMID: 30571459 Free PMC article.
Blinded coronary computed tomographic angiography coronary artery disease characterization included total burden, NCB, and dense-calcified burden. Compared with healthy volunteers, psoriasis subjects were older (mean age, 50.1), had increased body mass index, and homeostat …
Blinded coronary computed tomographic angiography coronary artery disease characterization included total burden, NCB, and dense-calc …
Association Between Aortic Vascular Inflammation and Coronary Artery Plaque Characteristics in Psoriasis.
Joshi AA, Lerman JB, Dey AK, Sajja AP, Belur AD, Elnabawi YA, Rodante JA, Aberra TM, Chung J, Salahuddin T, Natarajan B, Dave J, Goyal A, Groenendyk JW, Rivers JP, Baumer Y, Teague HL, Playford MP, Bluemke DA, Ahlman MA, Chen MY, Gelfand JM, Mehta NN. Joshi AA, et al. JAMA Cardiol. 2018 Oct 1;3(10):949-956. doi: 10.1001/jamacardio.2018.2769. JAMA Cardiol. 2018. PMID: 30208407 Free PMC article.

All associations of aortic VI remained significant after adjustment for cardiovascular risk factors: aortic VI and TB (beta = 0.23; P < .001), NCB (beta = 0.24; P < .001), luminal stenosis (OR, 3.40; 95% CI, 1.40-8.24; P = .007), and HRP (OR, 2.72; 95% CI, 1.08-6.83; P = .0

…

All associations of aortic VI remained significant after adjustment for cardiovascular risk factors: aortic VI and TB (beta = 0.23; P < .

…
Coronary 18F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome.
Majeed K, Bellinge JW, Butcher SC, Alcock R, Spiro J, Playford D, Hillis GS, Newby DE, Mori TA, Francis R, Schultz CJ. Majeed K, et al. Atherosclerosis. 2021 Feb;319:142-148. doi: 10.1016/j.atherosclerosis.2020.12.010. Epub 2020 Dec 15. Atherosclerosis. 2021. PMID: 33358367
RESULTS: In 62 patients (age, mean standard deviation (SD) = 61 9 years, 85% male) the coronary segments with elevated (18)F-NaF uptake had higher lipid arc (LA) (median [25th-75th centile]: 74 [35-117] versus 48 [15-83], p=0.021), higher prevalence of macrophages [n(%): 37 (62%) …
RESULTS: In 62 patients (age, mean standard deviation (SD) = 61 9 years, 85% male) the coronary segments with elevated (18)F-NaF uptake had …
Dyslipoproteinaemia and hyperoxidative stress in the pathogenesis of endothelial dysfunction in non-insulin dependent diabetes mellitus: an hypothesis.
Watts GF, Playford DA. Watts GF, et al. Atherosclerosis. 1998 Nov;141(1):17-30. doi: 10.1016/s0021-9150(98)00170-1. Atherosclerosis. 1998. PMID: 9863535
NIDDM results in diverse abnormalities in lipoprotein metabolism, the most significant being hypertriglyceridaemia which is associated with increased plasma concentrations of small dense LDL and low levels of HDL. Dysglycaemia results in hyperoxidative stress and increased …
NIDDM results in diverse abnormalities in lipoprotein metabolism, the most significant being hypertriglyceridaemia which is associated with …
Low-density lipoprotein size, high-density lipoprotein concentration, and endothelial dysfunction in non-insulin-dependent diabetes.
O'Brien SF, Watts GF, Playford DA, Burke V, O'Neal DN, Best JD. O'Brien SF, et al. Diabet Med. 1997 Nov;14(11):974-8. doi: 10.1002/(SICI)1096-9136(199711)14:11<974::AID-DIA495>3.0.CO;2-I. Diabet Med. 1997. PMID: 9400923
Vasodilatory responses to sodium nitroprusside were not significantly correlated with LDL particle size or serum lipid and lipoprotein concentrations. We conclude that in men with NIDDM, small, dense LDL particle size is associated with abnormal endogenous release of nitri …
Vasodilatory responses to sodium nitroprusside were not significantly correlated with LDL particle size or serum lipid and lipoprotein conce …
Oxidized LDL and small LDL particle size are independently predictive of a selective defect in microcirculatory endothelial function in type 2 diabetes.
Woodman RJ, Watts GF, Playford DA, Best JD, Chan DC. Woodman RJ, et al. Diabetes Obes Metab. 2005 Sep;7(5):612-7. doi: 10.1111/j.1463-1326.2005.00478.x. Diabetes Obes Metab. 2005. PMID: 16050955
There were no associations between LDL size, oxidized LDL, duration of diabetes and FBF response to BK, SNP, ACh + L-NMMA or BK + L-NMMA. CONCLUSION: In type 2 diabetes, small dense LDL particles, duration of diabetes and oxidized LDL may independently contribute to endoth …
There were no associations between LDL size, oxidized LDL, duration of diabetes and FBF response to BK, SNP, ACh + L-NMMA or BK + L-NMMA. CO …