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Year Number of Results
2004 1
2006 3
2007 1
2010 2
2014 2
2015 3
2016 1
2018 1
2024 0

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12 results

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Page 1
Predicting and tuning physicochemical properties in lead optimization: amine basicities.
Morgenthaler M, Schweizer E, Hoffmann-Röder A, Benini F, Martin RE, Jaeschke G, Wagner B, Fischer H, Bendels S, Zimmerli D, Schneider J, Diederich F, Kansy M, Müller K. Morgenthaler M, et al. Among authors: zimmerli d. ChemMedChem. 2007 Aug;2(8):1100-15. doi: 10.1002/cmdc.200700059. ChemMedChem. 2007. PMID: 17530727 Review.
Aminomethylpyridines as DPP-IV inhibitors.
Peters JU, Weber S, Kritter S, Weiss P, Wallier A, Zimmerli D, Boehringer M, Steger M, Loeffler BM. Peters JU, et al. Among authors: zimmerli d. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3579-80. doi: 10.1016/j.bmcl.2004.04.049. Bioorg Med Chem Lett. 2004. PMID: 15177478
Strain-accelerated formation of chiral, optically active buta-1,3-dienes.
Chiu M, Tchitchanov BH, Zimmerli D, Sanhueza IA, Schoenebeck F, Trapp N, Schweizer WB, Diederich F. Chiu M, et al. Among authors: zimmerli d. Angew Chem Int Ed Engl. 2015 Jan 2;54(1):349-54. doi: 10.1002/anie.201409289. Epub 2014 Nov 26. Angew Chem Int Ed Engl. 2015. PMID: 25425560
Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia.
Pinard E, Alanine A, Alberati D, Bender M, Borroni E, Bourdeaux P, Brom V, Burner S, Fischer H, Hainzl D, Halm R, Hauser N, Jolidon S, Lengyel J, Marty HP, Meyer T, Moreau JL, Mory R, Narquizian R, Nettekoven M, Norcross RD, Puellmann B, Schmid P, Schmitt S, Stalder H, Wermuth R, Wettstein JG, Zimmerli D. Pinard E, et al. Among authors: zimmerli d. J Med Chem. 2010 Jun 24;53(12):4603-14. doi: 10.1021/jm100210p. J Med Chem. 2010. PMID: 20491477
Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability.
Alberati D, Hainzl D, Jolidon S, Krafft EA, Kurt A, Maier A, Pinard E, Thomas AW, Zimmerli D. Alberati D, et al. Among authors: zimmerli d. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4311-5. doi: 10.1016/j.bmcl.2006.05.058. Epub 2006 Jun 6. Bioorg Med Chem Lett. 2006. PMID: 16757170
Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: achieving selectivity against the mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors.
Alberati D, Ceccarelli SM, Jolidon S, Krafft EA, Kurt A, Maier A, Pinard E, Stalder H, Studer D, Thomas AW, Zimmerli D. Alberati D, et al. Among authors: zimmerli d. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4305-10. doi: 10.1016/j.bmcl.2006.05.064. Epub 2006 Jun 9. Bioorg Med Chem Lett. 2006. PMID: 16762548
12 results