Dopamine delays articular cartilage degradation in osteoarthritis by negative regulation of the NF-κB and JAK2/STAT3 signaling pathways.
Lu W, Ding Z, Liu F, Shan W, Cheng C, Xu J, He W, Huang W, Ma J, Yin Z.
Lu W, et al.
Biomed Pharmacother. 2019 Nov;119:109419. doi: 10.1016/j.biopha.2019.109419. Epub 2019 Sep 25.
Biomed Pharmacother. 2019.
PMID: 31563117
Free article.
Mechanistically, DA reversed IL-1beta-treated nuclear factor-kappa B activation and JAK2/STAT3 phosphorylation. ...CONCLUSION: DA may be a novel therapeutic agent for OA treatment....
Mechanistically, DA reversed IL-1beta-treated nuclear factor-kappa B activation and JAK2/STAT3 phosphorylation. ...CONCLUSION: DA …