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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1975 1
1980 1
1984 1
1985 1
1988 1
1989 1
1990 1
1991 1
1994 1
1995 1
1996 1
1997 1
1999 1
2000 2
2001 3
2002 1
2003 3
2005 1
2006 5
2007 1
2008 1
2009 4
2010 1
2011 4
2013 1
2014 2
2015 1
2016 6
2017 3
2018 6
2019 3
2020 3
2021 4
2022 1
2023 5
2024 4

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77 results

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Page 1
Clinical utility of clonal origin determination in managing recurrent hepatocellular carcinoma.
Gupta S, Khan S, Kawka M, Gujjuri R, Chau I, Starling N, Cunningham D, Jiao LR, Gall T. Gupta S, et al. Expert Rev Gastroenterol Hepatol. 2021 Oct;15(10):1159-1167. doi: 10.1080/17474124.2021.1967144. Epub 2021 Aug 18. Expert Rev Gastroenterol Hepatol. 2021. PMID: 34402366 Review.
Medline, EMBASE and Cochrane library were methodically searched for primary research articles in English with the aim of appraising existing literature on the identification of clonal origin of RHCC and its potential clinical utility. AREAS COVERED: Molecular and next-gene …
Medline, EMBASE and Cochrane library were methodically searched for primary research articles in English with the aim of appraising existing …
Genetic and immune landscape evolution in MMR-deficient colorectal cancer.
Challoner BR, Woolston A, Lau D, Buzzetti M, Fong C, Barber LJ, Anandappa G, Crux R, Assiotis I, Fenwick K, Begum R, Begum D, Lund T, Sivamanoharan N, Sansano HB, Domingo-Arada M, Tran A, Pandha H, Church D, Eccles B, Ellis R, Falk S, Hill M, Krell D, Murugaesu N, Nolan L, Potter V, Saunders M, Shiu KK, Guettler S, Alexander JL, Lázare-Iglesias H, Kinross J, Murphy J, von Loga K, Cunningham D, Chau I, Starling N, Ruiz-Bañobre J, Dhillon T, Gerlinger M. Challoner BR, et al. J Pathol. 2024 Feb;262(2):226-239. doi: 10.1002/path.6228. Epub 2023 Nov 15. J Pathol. 2024. PMID: 37964706
These IE drivers have been implicated in immune checkpoint inhibitor resistance or sensitivity. Clonality assessments are therefore important for the development of predictive immunotherapy biomarkers in MMRd CRCs. ...
These IE drivers have been implicated in immune checkpoint inhibitor resistance or sensitivity. Clonality assessments are therefore i …
The significance of natural autoantibodies.
Tomer Y, Shoenfeld Y. Tomer Y, et al. Immunol Invest. 1988 Jul;17(5):389-424. doi: 10.3109/08820138809049846. Immunol Invest. 1988. PMID: 3058585 Review.
Despite the fact that numerous hypotheses explaining the origin of natural autoantibodies have been postulated only the two important ones will be discussed. The first, proposed by Cunningham, holds that clonal deletion as viewed by Burnet operates in early life; ho …
Despite the fact that numerous hypotheses explaining the origin of natural autoantibodies have been postulated only the two important ones w …
Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia.
Fola AA, Feleke SM, Mohammed H, Brhane BG, Hennelly CM, Assefa A, Crudal RM, Reichert E, Juliano JJ, Cunningham J, Mamo H, Solomon H, Tasew G, Petros B, Parr JB, Bailey JA. Fola AA, et al. Nat Microbiol. 2023 Oct;8(10):1911-1919. doi: 10.1038/s41564-023-01461-4. Epub 2023 Aug 28. Nat Microbiol. 2023. PMID: 37640962 Free PMC article.
Pfhrp2/3-deleted parasites were also highly related, with evidence of clonal transmissions at the district level. Of concern, 8.2% of K13 622I parasites also carried the pfhrp2/3 deletions. ...
Pfhrp2/3-deleted parasites were also highly related, with evidence of clonal transmissions at the district level. Of concern, 8.2% of …
Genomic landscape of patients with germline RUNX1 variants and familial platelet disorder with myeloid malignancy.
Yu K, Deuitch N, Merguerian M, Cunningham L, Davis J, Bresciani E, Diemer J, Andrews E, Young A, Donovan F, Sood R, Craft K, Chong S, Chandrasekharappa S, Mullikin J, Liu PP. Yu K, et al. Blood Adv. 2024 Jan 23;8(2):497-511. doi: 10.1182/bloodadvances.2023011165. Blood Adv. 2024. PMID: 38019014 Free PMC article.
In 25 of 51 (49%) patients without hematologic malignancy, somatic mutations were detected in at least 1 of the clonal hematopoiesis of indeterminate potential (CHIP) genes or acute myeloid leukemia (AML) driver genes. ...In summary, there are diverse types of germline RUN …
In 25 of 51 (49%) patients without hematologic malignancy, somatic mutations were detected in at least 1 of the clonal hematopoiesis …
The evolutionary landscape of colorectal tumorigenesis.
Cross W, Kovac M, Mustonen V, Temko D, Davis H, Baker AM, Biswas S, Arnold R, Chegwidden L, Gatenbee C, Anderson AR, Koelzer VH, Martinez P, Jiang X, Domingo E, Woodcock DJ, Feng Y, Kovacova M, Maughan T; S:CORT Consortium; Jansen M, Rodriguez-Justo M, Ashraf S, Guy R, Cunningham C, East JE, Wedge DC, Wang LM, Palles C, Heinimann K, Sottoriva A, Leedham SJ, Graham TA, Tomlinson IPM. Cross W, et al. Nat Ecol Evol. 2018 Oct;2(10):1661-1672. doi: 10.1038/s41559-018-0642-z. Epub 2018 Aug 31. Nat Ecol Evol. 2018. PMID: 30177804 Free PMC article.
Unlike carcinomas, advanced adenomas frequently harbour sub-clonal driver mutations-considered to be functionally important in the carcinogenic process-that have not swept to fixation, and have relatively high genetic heterogeneity. Carcinomas are distinguished from adenom …
Unlike carcinomas, advanced adenomas frequently harbour sub-clonal driver mutations-considered to be functionally important in the ca …
FTOC-Based Analysis of Negative Selection.
Cunningham CA, Teixeiro E, Daniels MA. Cunningham CA, et al. Methods Mol Biol. 2016;1323:141-9. doi: 10.1007/978-1-4939-2809-5_12. Methods Mol Biol. 2016. PMID: 26294405
Genomic Landscape of Patients with Germline RUNX1 Variants and Familial Platelet Disorder with Myeloid Malignancy.
Yu K, Deuitch N, Merguerian M, Cunningham L, Davis J, Bresciani E, Diemer J, Andrews E, Young A, Donovan F, Sood R, Craft K, Chong S, Chandrasekharappa S, Mullikin J, Liu PP. Yu K, et al. bioRxiv [Preprint]. 2023 Jan 17:2023.01.17.524290. doi: 10.1101/2023.01.17.524290. bioRxiv. 2023. PMID: 36789433 Free PMC article. Updated. Preprint.
In 24 of 54 (44.4%) non-malignant patients, somatic mutations were detected in at least one of the clonal hematopoiesis of indeterminate potential (CHIP) genes or acute myeloid leukemia (AML) driver genes. ...KEY POINTS: Comprehensive genomic profile of patients with FPDMM …
In 24 of 54 (44.4%) non-malignant patients, somatic mutations were detected in at least one of the clonal hematopoiesis of indetermin …
Clonal diversity of MYC amplification evaluated by fluorescent in situ hybridisation and digital droplet polymerase chain reaction in oesophagogastric cancer: Results from a prospective clinical trial screening programme.
Davidson M, Aronson LI, Howard-Reeves J, Bryant H, Cutts RJ, Hulkki-Wilson S, Kouvelakis K, Kalaitzaki E, Watkins D, Starling N, Rao S, Cardenosa ML, Begum R, Rana I, Lazaro-Alcausi R, Terlizzo M, Wotherspoon A, Brown G, Swansbury J, Lord CJ, Cunningham D, Chau I, Chong IY. Davidson M, et al. Eur J Cancer. 2019 Nov;122:12-21. doi: 10.1016/j.ejca.2019.09.003. Epub 2019 Oct 10. Eur J Cancer. 2019. PMID: 31606655 Clinical Trial.
Intertumour heterogeneity was observed, with the percentage of cancer cells harbouring MYC amplification ranging widely between samples (median 51%, range 11-94%). Intratumoural clonal diversity of MYC amplification was also observed, with a significant degree of variance …
Intertumour heterogeneity was observed, with the percentage of cancer cells harbouring MYC amplification ranging widely between samples (med …
High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial.
Pearson A, Smyth E, Babina IS, Herrera-Abreu MT, Tarazona N, Peckitt C, Kilgour E, Smith NR, Geh C, Rooney C, Cutts R, Campbell J, Ning J, Fenwick K, Swain A, Brown G, Chua S, Thomas A, Johnston SRD, Ajaz M, Sumpter K, Gillbanks A, Watkins D, Chau I, Popat S, Cunningham D, Turner NC. Pearson A, et al. Cancer Discov. 2016 Aug;6(8):838-851. doi: 10.1158/2159-8290.CD-15-1246. Epub 2016 May 13. Cancer Discov. 2016. PMID: 27179038 Free PMC article.
In a translational clinical trial, we show that gastric cancers with high-level clonal FGFR2 amplification have a high response rate to the selective FGFR inhibitor AZD4547, whereas cancers with subclonal or low-level amplification did not respond. ...Finally, we show that …
In a translational clinical trial, we show that gastric cancers with high-level clonal FGFR2 amplification have a high response rate …
77 results