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Page 1
Process Development of a Macrocyclic Peptide Inhibitor of PD-L1.
Mukherjee S, Rogers A, Creech G, Hang C, Ramirez A, Dummeldinger M, Brueggemeier S, Mapelli C, Zaretsky S, Huang M, Black R, Peddicord MB, Cuniere N, Kempson J, Pawluczyk J, Allen M, Parsons R, Sfouggatakis C. Mukherjee S, et al. Among authors: mapelli c. J Org Chem. 2024 Apr 25. doi: 10.1021/acs.joc.4c00430. Online ahead of print. J Org Chem. 2024. PMID: 38663026
Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene.
Demma MJ, Mapelli C, Sun A, Bodea S, Ruprecht B, Javaid S, Wiswell D, Muise E, Chen S, Zelina J, Orvieto F, Santoprete A, Altezza S, Tucci F, Escandon E, Hall B, Ray K, Walji A, O'Neil J. Demma MJ, et al. Among authors: mapelli c. Mol Cell Biol. 2019 Oct 28;39(22):e00248-19. doi: 10.1128/MCB.00248-19. Print 2019 Nov 15. Mol Cell Biol. 2019. PMID: 31501275 Free PMC article.
Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain Truncations.
Brown ZZ, Mapelli C, Farasat I, Shoultz AV, Johnson SA, Orvieto F, Santoprete A, Bianchi E, McCracken AB, Chen K, Zhu X, Demma MJ, Lacey BM, Canada KA, Garbaccio RM, O'Neil J, Walji A. Brown ZZ, et al. Among authors: mapelli c. J Org Chem. 2020 Feb 7;85(3):1466-1475. doi: 10.1021/acs.joc.9b02467. Epub 2019 Nov 25. J Org Chem. 2020. PMID: 31660743
Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity.
Mapelli C, Natarajan SI, Meyer JP, Bastos MM, Bernatowicz MS, Lee VG, Pluscec J, Riexinger DJ, Sieber-McMaster ES, Constantine KL, Smith-Monroy CA, Golla R, Ma Z, Longhi DA, Shi D, Xin L, Taylor JR, Koplowitz B, Chi CL, Khanna A, Robinson GW, Seethala R, Antal-Zimanyi IA, Stoffel RH, Han S, Whaley JM, Huang CS, Krupinski J, Ewing WR. Mapelli C, et al. J Med Chem. 2009 Dec 10;52(23):7788-99. doi: 10.1021/jm900752a. J Med Chem. 2009. PMID: 19702274
Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers.
Modugno M, Banfi P, Gasparri F, Borzilleri R, Carter P, Cornelius L, Gottardis M, Lee V, Mapelli C, Naglich JG, Tebben A, Vite G, Pastori W, Albanese C, Corti E, Ballinari D, Galvani A. Modugno M, et al. Among authors: mapelli c. Exp Cell Res. 2015 Mar 15;332(2):267-77. doi: 10.1016/j.yexcr.2014.11.022. Epub 2014 Dec 5. Exp Cell Res. 2015. PMID: 25486070
16 results