Objective: To observe the effects ot Guben Yiliu II (GY II) combined with arterial perfusion with chemotherapeutic agent on advanced pancreatic cancer (APC).
Methods: Sixty-five APC patients were randomly assigned to the treated group (35 cases) given GY II and arterial perfusion with chemotherapeutic agent and the control group (30 cases) with chemotherapeutic agent alone.
Results: The clinical beneficial rate was 54.2% in the treated group and 40.0% in the control group, with significant difference between them (P < 0.05), the overall effective rate being 17.1% and 13.3%, and the effective rate in relieving pain being 64.5% and 59.2% in the treated and the control group respectively, all showed insignificant difference between groups (P > 0.05). Furthermore, in the treated group after treatment, the blood hypercoagulation state ameliorated, cellular immunity elevated, the toxic and side- effects of chemical medicine relieved, and the quality of life improved.
Conclusion: GY II is effective in enhancing clinical effects and relieving toxic and side-effects of chemotherapy, and so, better efficacy could be obtained by therapy of GY II and arterial perfusion with chemotherapeutic agent for treatment of APC.