Relationship between CIP2A expression, and prognosis and MDR-related proteins in patients with advanced gastric cancer

Int J Clin Exp Pathol. 2015 Nov 1;8(11):15007-12. eCollection 2015.

Abstract

CIP2A is highly expressed in a variety of malignancies. We determined the expression and clinical significance of CIP2A in patients with advanced gastric cancer. CIP2A protein was expressed in 25 of 37 cancer tissue specimens. There was no correlation between CIP2A and PGP, GST-π, Topo-II, and LRP expression. Survival analysis showed significant differences between the survival rate of the CIP2A protein-positive and -negative groups (χ(2)=4.509, P=0.034), but the degree of positive expression was unrelated to survival time (χ(2)=4.639, P=0.098). CIP2A expression may have no prospective value for optimizing chemotherapy regimens, but it can be an indicator for patient prognosis.

Keywords: CIP2A; Gastric cancer; Helicobacter pylori; MRD; p53; survival time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / analysis
  • ATP Binding Cassette Transporter, Subfamily B / biosynthesis*
  • Adenocarcinoma / metabolism
  • Adenocarcinoma / mortality
  • Adenocarcinoma / pathology*
  • Adult
  • Aged
  • Autoantigens / analysis
  • Autoantigens / biosynthesis*
  • Biomarkers, Tumor / analysis*
  • Female
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Kaplan-Meier Estimate
  • Male
  • Membrane Proteins / analysis
  • Membrane Proteins / biosynthesis*
  • Middle Aged
  • Prognosis
  • Stomach Neoplasms / metabolism
  • Stomach Neoplasms / mortality
  • Stomach Neoplasms / pathology*

Substances

  • ATP Binding Cassette Transporter, Subfamily B
  • Autoantigens
  • Biomarkers, Tumor
  • CIP2A protein, human
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins