Photoacoustic spectroscopy that uses a resonant characteristic of a microphone for in vitro measurements of glucose concentration

Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug:2016:4861-4864. doi: 10.1109/EMBC.2016.7591816.

Abstract

Glucose measurements using photoacoustic spectroscopy have been highlighted to be a modality for non-invasive glucose monitoring. Previous photoacoustic spectroscopy for glucose measurements have used a resonant acoustic cell with a broadband capacitive microphone to increase sensitivity. However, a resonant characteristic of a microphone has not been investigated yet due to the working frequency range much lower than the resonance frequency of the microphone membrane. We, here, present a photoacoustic spectroscopy system that utilizes an ultrasound resonance of a microphone to increase sensitivity. We found that matching the resonance of a photoacoustic cell with the resonance of a microphone can increase signal-to-noise ratio and our system can distinguish the glucose concentration in liquid.

MeSH terms

  • Extracellular Fluid / chemistry
  • Glucose / analysis*
  • Least-Squares Analysis
  • Photoacoustic Techniques / instrumentation*
  • Regression Analysis
  • Signal Processing, Computer-Assisted
  • Spectrum Analysis / methods*

Substances

  • Glucose