Bioactive secondary metabolites from marine microbes for drug discovery

Adv Food Nutr Res. 2012:65:363-87. doi: 10.1016/B978-0-12-416003-3.00024-X.

Abstract

The isolation and extraction of novel bioactive secondary metabolites from marine microorganisms have a biomedical potential for future drug discovery as the oceans cover 70% of the planet's surface and life on earth originates from sea. Wide range of novel bioactive secondary metabolites exhibiting pharmacodynamic properties has been isolated from marine microorganisms and many to be discovered. The compounds isolated from marine organisms (macro and micro) are important in their natural form and also as templates for synthetic modifications for the treatments for variety of deadly to minor diseases. Many technical issues are yet to overcome before wide-scale bioprospecting of marine microorganisms becomes a reality. This chapter focuses on some novel secondary metabolites having antitumor, antivirus, enzyme inhibitor, and other bioactive properties identified and isolated from marine microorganisms including bacteria, actinomycetes, fungi, and cyanobacteria, which could serve as potentials for drug discovery after their clinical trials.

Publication types

  • Review

MeSH terms

  • Actinomyces / growth & development
  • Actinomyces / isolation & purification
  • Actinomyces / metabolism
  • Animals
  • Antibiotics, Antineoplastic / biosynthesis
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / isolation & purification
  • Antibiotics, Antineoplastic / pharmacology
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / metabolism
  • Antiviral Agents / pharmacology
  • Aquatic Organisms / growth & development
  • Aquatic Organisms / isolation & purification
  • Aquatic Organisms / metabolism*
  • Aquatic Organisms / microbiology
  • Cyanobacteria / growth & development
  • Cyanobacteria / isolation & purification
  • Cyanobacteria / metabolism
  • Drug Discovery*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / metabolism
  • Enzyme Inhibitors / pharmacology
  • Fungi / growth & development
  • Fungi / isolation & purification
  • Fungi / metabolism*
  • Gram-Negative Bacteria / growth & development
  • Gram-Negative Bacteria / isolation & purification
  • Gram-Negative Bacteria / metabolism*
  • Gram-Positive Bacteria / growth & development
  • Gram-Positive Bacteria / isolation & purification
  • Gram-Positive Bacteria / metabolism*
  • Humans
  • Metabolome*
  • Symbiosis

Substances

  • Antibiotics, Antineoplastic
  • Antiviral Agents
  • Enzyme Inhibitors