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Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016.
Tomás CC, Oliveira E, Sousa D, Uba-Chupel M, Furtado G, Rocha C, Teixeira A, Ferreira P, Alves C, Gisin S, Catarino E, Carvalho N, Coucelo T, Bonfim L, Silva C, Franco D, González JA, Jardim HG, Silva R, Baixinho CL, Presado MªH, Marques MªF, Cardoso ME, Cunha M, Mendes J, Xavier A, Galhardo A, Couto M, Frade JG, Nunes C, Mesquita JR, Nascimento MS, Gonçalves G, Castro C, Mártires A, Monteiro MªJ, Rainho C, Caballero FP, Monago FM, Guerrero JT, Monago RM, Trigo AP, Gutierrez ML, Milanés GM, Reina MG, Villanueva AG, Piñero AS, Aliseda IR, Ramirez FB, Ribeiro A, Quelhas A, Manso C, Caballero FP, Guerrero JT, Monago FM, Santos RB, Jimenez NR, Nuñez CG, Gomez IR, Fernandez MªJL, Marquez LA, Moreno AL, Huertas MªJT, Ramirez FB, Seabra D, Salvador MªC, Braga L, Parreira P, Salgueiro-Oliveira A, Arreguy-Sena C, Oliveira BF, Henriques MªA, Santos J, Lebre S, Marques A, Festas C, Rodrigues S, Ribeiro A, Lumini J, Figueiredo AG, Hernandez-Martinez FJ, Campi L, Quintana-Montesdeoca MªP, Jimenez-Diaz JF, Rodriguez-De-Vera BC, Parente A, Mata MªA, Pereira AMª, Fernandes A, Brás M, Pinto MªR, Parreira P, Basto ML, Rei AC, Mónico LM, Sousa G, Morna C, Freitas O, Freitas G, Jardim A, Vasconcelos … See abstract for full author list ➔ Tomás CC, et al. BMC Health Serv Res. 2016 Jul 6;16 Suppl 3(Suppl 3):200. doi: 10.1186/s12913-016-1423-5. BMC Health Serv Res. 2016. PMID: 27409075 Free PMC article.
Parraca, Narcis Gusi O163 Preliminary study of the adaptation and validation of the Rating Scale of Resilient Self: Resilience, self-harm and suicidal ideation in adolescents Jani Sousa, Mariana Marques, Jacinto Jardim, Anabela Pereira, Sonia Simoes, Marina Cunha O164 Development …
Parraca, Narcis Gusi O163 Preliminary study of the adaptation and validation of the Rating Scale of Resilient Self: Resilience, self-harm an …
A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways.
Chen CX, Zhang W, Qu S, Xia F, Zhu Y, Chen B. Chen CX, et al. Cell Commun Signal. 2023 Oct 16;21(1):287. doi: 10.1186/s12964-023-01299-7. Cell Commun Signal. 2023. PMID: 37845748 Free PMC article.
However, targeting the catalytic region of the TYK2 ATP-binding site is a major challenge due to the high structural homology between the catalytic regions of the JAK family proteins. RESULTS: In this study, we developed a novel small molecule inhibitor (QL-1200186) by tar …
However, targeting the catalytic region of the TYK2 ATP-binding site is a major challenge due to the high structural homology between the ca …
Embracing sleep-onset complexity.
Lacaux C, Strauss M, Bekinschtein TA, Oudiette D. Lacaux C, et al. Trends Neurosci. 2024 Apr;47(4):273-288. doi: 10.1016/j.tins.2024.02.002. Epub 2024 Mar 21. Trends Neurosci. 2024. PMID: 38519370 Review.
Finally, we discuss the putative cognitive benefits of the SOP and identify novel directions to better diagnose sleep-onset disorders....
Finally, we discuss the putative cognitive benefits of the SOP and identify novel directions to better diagnose sleep-onset disorders …
Heme uptake in bacterial pathogens.
Contreras H, Chim N, Credali A, Goulding CW. Contreras H, et al. Curr Opin Chem Biol. 2014 Apr;19:34-41. doi: 10.1016/j.cbpa.2013.12.014. Epub 2014 Jan 4. Curr Opin Chem Biol. 2014. PMID: 24780277 Free PMC article. Review.
The pathways for heme transport into the bacterial cytosol are divergent, harboring non-homologous protein sequences, novel structures, varying numbers of proteins, and different mechanisms. ...
The pathways for heme transport into the bacterial cytosol are divergent, harboring non-homologous protein sequences, novel structure …
A novel covalent enzyme-linked immunoassay (CELIA) for simultaneously measuring free and immune complex bound antibodies of defined specificity. I. Application to naturally occurring antipolyamine antibodies in human sera.
Roch AM, Delcros JG, Ripoll JP, Thomas V, Richard J, Quash G. Roch AM, et al. J Immunol Methods. 1990 Oct 4;133(1):1-11. doi: 10.1016/0022-1759(90)90312-j. J Immunol Methods. 1990. PMID: 2212682
A simple covalent enzyme-linked immunoassay procedure (CELIA) is described for the routine determination of free and immune complex-bound antibodies in sera. ...
A simple covalent enzyme-linked immunoassay procedure (CELIA) is described for the routine determination of free and immune complex-b …
Improving Viral Protease Inhibitors to Counter Drug Resistance.
Kurt Yilmaz N, Swanstrom R, Schiffer CA. Kurt Yilmaz N, et al. Trends Microbiol. 2016 Jul;24(7):547-557. doi: 10.1016/j.tim.2016.03.010. Epub 2016 Apr 15. Trends Microbiol. 2016. PMID: 27090931 Free PMC article. Review.
Drug resistance is a major problem in health care, undermining therapy outcomes and necessitating novel approaches to drug design. Extensive studies on resistance to viral protease inhibitors, particularly those of HIV-1 and hepatitis C virus (HCV) protease, revealed a ple …
Drug resistance is a major problem in health care, undermining therapy outcomes and necessitating novel approaches to drug design. Ex …
Ureases as multifunctional toxic proteins: A review.
Carlini CR, Ligabue-Braun R. Carlini CR, et al. Toxicon. 2016 Feb;110:90-109. doi: 10.1016/j.toxicon.2015.11.020. Epub 2015 Dec 12. Toxicon. 2016. PMID: 26690979 Review.
They were the first enzymes to be crystallized and, with them, the notion that enzymes are proteins became accepted. Novel toxic properties of ureases that are independent of their enzyme activity have been discovered in the last three decades. ...
They were the first enzymes to be crystallized and, with them, the notion that enzymes are proteins became accepted. Novel toxic prop …
A novel covalent enzyme-linked immunoassay (CELIA) for simultaneously measuring free and immune complex bound antibodies with a defined specificity. II. Application to immune complexes containing viral antigens in human sera.
Thomas V, El Alaoui S, Roch AM, Quash G. Thomas V, et al. J Immunol Methods. 1990 Oct 4;133(1):13-9. doi: 10.1016/0022-1759(90)90313-k. J Immunol Methods. 1990. PMID: 2170536
The coupling of viral antigens from parainfluenza virus (PIV-1), cytomegalovirus (CMV) and human immunodeficiency virus (HIV-1) to chemically functionalized polystyrene plates has permitted us to develop a covalent enzyme-linked immunoassay (CELIA) for measuring the titers …
The coupling of viral antigens from parainfluenza virus (PIV-1), cytomegalovirus (CMV) and human immunodeficiency virus (HIV-1) to chemicall …
88 results