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Theoretical and Biological Evaluation of the Link between Low Exercise Capacity and Disease Risk.
Koch LG, Britton SL. Koch LG, et al. Among authors: britton sl. Cold Spring Harb Perspect Med. 2018 Jan 2;8(1):a029868. doi: 10.1101/cshperspect.a029868. Cold Spring Harb Perspect Med. 2018. PMID: 28389512 Free PMC article. Review.
Large-scale epidemiological studies show that low exercise capacity is the highest risk factor for all-cause morbidity and mortality relative to other conditions including diabetes, hypertension, and obesity. ...
Large-scale epidemiological studies show that low exercise capacity is the highest risk factor for all-cause morbidity and mortality …
2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology.
Lucchino M, Billet A, Versini A, Bavireddi H, Dasari BD, Debieu S, Colombeau L, Cañeque T, Wagner A, Masson G, Taran F, Karoyan P, Delepierre M, Gaillet C, Houdusse A, Britton S, Schmidt F, Florent JC, Belmont P, Monchaud D, Cossy J, Thomas C, Gautier A, Johannes L, Rodriguez R. Lucchino M, et al. Among authors: britton s. Chembiochem. 2019 Apr 1;20(7):968-973. doi: 10.1002/cbic.201900092. Epub 2019 Feb 25. Chembiochem. 2019. PMID: 30803119
Chemical Biology is the science of designing chemical tools to dissect and manipulate biology at different scales. It provides the fertile ground from which to address important problems of our society, such as human health and environment....
Chemical Biology is the science of designing chemical tools to dissect and manipulate biology at different scales. It provides the fe …
Evolution, atmospheric oxygen, and complex disease.
Koch LG, Britton SL. Koch LG, et al. Among authors: britton sl. Physiol Genomics. 2007 Aug 20;30(3):205-8. doi: 10.1152/physiolgenomics.00043.2007. Epub 2007 May 1. Physiol Genomics. 2007. PMID: 17473218
In accord with this thesis, clinical studies reveal a strong statistical link between low aerobic capacity and all-cause mortality. In addition, large-scale unbiased network analyses demonstrate the pivotal role of oxygen metabolism in cellular function. ...
In accord with this thesis, clinical studies reveal a strong statistical link between low aerobic capacity and all-cause mortality. In addit …
Determining Pneumocystis jirovecii Colonisation from Infection Using PCR-Based Diagnostics in HIV-Negative Individuals.
Watson AL, Woodford J, Britton S, Gupta R, Whiley D, McCarthy K. Watson AL, et al. Among authors: britton s. Diagnostics (Basel). 2024 Jan 4;14(1):114. doi: 10.3390/diagnostics14010114. Diagnostics (Basel). 2024. PMID: 38201422 Free PMC article.
Standardisation of assays with prospective validation in specific immunocompromised groups will allow greater generalisability and allow large-scale prospective assay validation to be performed....
Standardisation of assays with prospective validation in specific immunocompromised groups will allow greater generalisability and allow lar …
Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training.
Ahtiainen JP, Lensu S, Ruotsalainen I, Schumann M, Ihalainen JK, Fachada V, Mendias CL, Brook MS, Smith K, Atherton PJ, Koch LG, Britton SL, Kainulainen H. Ahtiainen JP, et al. Among authors: britton sl. Exp Physiol. 2018 Nov;103(11):1513-1523. doi: 10.1113/EP087144. Epub 2018 Oct 9. Exp Physiol. 2018. PMID: 30184287 Free PMC article.
The daily protein synthesis rate was determined by the deuterium oxide method from the left quadriceps femoris muscle. Tissue weights of fore- and hindlimb muscles were measured. In response to resistance training, maximal carrying capacity was greater in HRT (3.3 times bo …
The daily protein synthesis rate was determined by the deuterium oxide method from the left quadriceps femoris muscle. Tissue weights …
Contribution of nascent cohesive fiber-fiber interactions to the non-linear elasticity of fibrin networks under tensile load.
Britton S, Kim O, Pancaldi F, Xu Z, Litvinov RI, Weisel JW, Alber M. Britton S, et al. Acta Biomater. 2019 Aug;94:514-523. doi: 10.1016/j.actbio.2019.05.068. Epub 2019 May 30. Acta Biomater. 2019. PMID: 31152942 Free PMC article.
The computational model enabled us to study structural details and quantify mechanical effects of the fiber-fiber cohesive crisscrossing during stretching of fibrin gels at various spatial scales. The contribution of the fiber-fiber cohesive contacts to the elasticity of s …
The computational model enabled us to study structural details and quantify mechanical effects of the fiber-fiber cohesive crisscrossing dur …
Selectively bred rat model system for low and high response to exercise training.
Koch LG, Pollott GE, Britton SL. Koch LG, et al. Among authors: britton sl. Physiol Genomics. 2013 Jul 15;45(14):606-14. doi: 10.1152/physiolgenomics.00021.2013. Epub 2013 May 28. Physiol Genomics. 2013. PMID: 23715262 Free PMC article.
We initiated a large-scale bidirectional selection experiment in a genetically heterogeneous rat population (N/NIH stock, n = 152) to develop lines of low response trainers (LRT) and high response trainers (HRT) as a contrasting animal model system. ...
We initiated a large-scale bidirectional selection experiment in a genetically heterogeneous rat population (N/NIH stock, n = 152) to …
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans.
Timmons JA, Knudsen S, Rankinen T, Koch LG, Sarzynski M, Jensen T, Keller P, Scheele C, Vollaard NB, Nielsen S, Akerström T, MacDougald OA, Jansson E, Greenhaff PL, Tarnopolsky MA, van Loon LJ, Pedersen BK, Sundberg CJ, Wahlestedt C, Britton SL, Bouchard C. Timmons JA, et al. Among authors: britton sl. J Appl Physiol (1985). 2010 Jun;108(6):1487-96. doi: 10.1152/japplphysiol.01295.2009. Epub 2010 Feb 4. J Appl Physiol (1985). 2010. PMID: 20133430 Free PMC article.
We discovered a 29-RNA signature that predicted VO2max training response on a continuous scale; these genes contained approximately 6 new single-nucleotide polymorphisms associated with gains in VO2max in the HERITAGE Family Study. ...
We discovered a 29-RNA signature that predicted VO2max training response on a continuous scale; these genes contained approximately 6 …
14 results