Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy

Po-Jung Chen; Yi-Da Kang; Chen-Huan Lin; San-Yuan Chen; Chia-Hung Hsieh; You-Yin Chen; Chun-Wei Chiang; Wei Lee; Chung-Y Hsu; Lun-De Liao; Chih-Tai Fan; Meng-Lin Li; Woei-Cherng Shyu

doi:10.1002/adma.201502784

Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy

Adv Mater. 2015 Nov 4;27(41):6488-95. doi: 10.1002/adma.201502784. Epub 2015 Sep 25.

Authors

Po-Jung Chen¹, Yi-Da Kang¹, Chen-Huan Lin², San-Yuan Chen¹, Chia-Hung Hsieh³, You-Yin Chen⁴, Chun-Wei Chiang², Wei Lee², Chung-Y Hsu⁵, Lun-De Liao^{6

7}, Chih-Tai Fan⁸, Meng-Lin Li^{8

9}, Woei-Cherng Shyu^{2

10}

Affiliations

¹ Department of Materials Science and Engineering, National Chiao Tung University, No. 1001, Ta-Hsueh Rd., Hsinchu, Taiwan, 300, Republic of China.
² Center for Neuropsychiatry and Department of Neurology, China Medical University & Hospital, Taichung, Taiwan, 40447, Republic of China.
³ Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, 40402, Republic of China.
⁴ Department of Biomedical Engineering, National Yang Ming University, No.155, Sec. 2, Linong St., Taipei, Taiwan, 112, Republic of China.
⁵ Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, 40402, Republic of China.
⁶ Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, #05-COR, 117456, Singapore.
⁷ Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35 Keyan Rd., Zhunan Town, Miaoli County, Taiwan, 35053, Republic of China.
⁸ Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan, 30013, Republic of China.
⁹ Institute of Photonics Technologies, National Tsing Hua University, Hsinchu, Taiwan, 30013, Republic of China.
¹⁰ Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, 40402, Republic of China.

PMID: 26403165
DOI: 10.1002/adma.201502784

Abstract

A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi-gold nanorods crystal-seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote-controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long-term monitoring to achieve therapeutic efficacy.

Keywords: magnetic resonance imaging; mesenchymal stem cells; multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin; photoacoustic imaging; stroke therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, CD / metabolism
Brain / diagnostic imaging
Brain / pathology
Cell Differentiation / drug effects
Cell Proliferation / drug effects
Cells, Cultured
Contrast Media / chemistry
Ferrosoferric Oxide / chemistry
Flow Cytometry
Gold / chemistry*
Humans
Magnetite Nanoparticles / chemistry*
Male
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / metabolism
Mice
Mice, Inbred C57BL
Nanotubes / chemistry*
Nanotubes / toxicity
Nanotubes / ultrastructure
Radiography
Stroke / therapy*
Wharton Jelly / cytology

Substances

Antigens, CD
Contrast Media
Magnetite Nanoparticles
Gold
Ferrosoferric Oxide