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1968 1
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Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1.
Nutter CA, Kidd BM, Carter HA, Hamel JI, Mackie PM, Kumbkarni N, Davenport ML, Tuyn DM, Gopinath A, Creigh PD, Sznajder ŁJ, Wang ET, Ranum LPW, Khoshbouei H, Day JW, Sampson JB, Prokop S, Swanson MS. Nutter CA, et al. Brain. 2023 Oct 3;146(10):4217-4232. doi: 10.1093/brain/awad148. Brain. 2023. PMID: 37143315
Although myotonic dystrophy is classified as a muscular dystrophy, the brain is also severely affected by an unusual cohort of symptoms, including hypersomnia, executive dysfunction, as well as early onsets of tau/MAPT pathology and cerebral atrophy. ...Choroid plexus tran …
Although myotonic dystrophy is classified as a muscular dystrophy, the brain is also severely affected by an unusual cohort of sympto …
Autistic traits in myotonic dystrophy type 1 due to MBNL inhibition and RNA mis-splicing.
Sznajder L, Khan M, Tadross M, Ciesiołka A, Nutter C, Taylor K, Pearson C, Sobczak K, Lewis M, Swanson M, Yuen R. Sznajder L, et al. Res Sq [Preprint]. 2023 Aug 14:rs.3.rs-3221704. doi: 10.21203/rs.3.rs-3221704/v1. Res Sq. 2023. PMID: 37645891 Free PMC article. Preprint.
We found that inhibition of muscleblind-like (MBNL) splicing factors by expanded CUG RNAs alerts the splicing of autism-risk genes during brain development especially a class of autism-relevant microexons. ...
We found that inhibition of muscleblind-like (MBNL) splicing factors by expanded CUG RNAs alerts the splicing of autism-risk genes during …
Visualizing temporal brain-state changes for fMRI using t-distributed stochastic neighbor embedding.
Parmar H, Nutter B, Long R, Antani S, Mitra S. Parmar H, et al. J Med Imaging (Bellingham). 2021 Jul;8(4):046001. doi: 10.1117/1.JMI.8.4.046001. Epub 2021 Aug 16. J Med Imaging (Bellingham). 2021. PMID: 34423072 Free PMC article.
Apart from visualization, we also show its utility in detection of major changes in the brain meta-states during the scan duration. Results: The t-SNE approach is able to detect brain-state changes from task to rest and vice versa for single- and multitask fMRI data …
Apart from visualization, we also show its utility in detection of major changes in the brain meta-states during the scan duration. R …
Multiple-mouse magnetic resonance imaging with cryogenic radiofrequency probes for evaluation of brain development.
Arbabi A, Spencer Noakes L, Vousden D, Dazai J, Spring S, Botelho O, Keshavarzian T, Mattingly M, Ellegood JE, Nutter LMJ, Wissmann R, Sled JG, Lerch JP, Henkelman RM, Nieman BJ. Arbabi A, et al. Neuroimage. 2022 May 15;252:119008. doi: 10.1016/j.neuroimage.2022.119008. Epub 2022 Mar 1. Neuroimage. 2022. PMID: 35245675 Free article.
The approach is demonstrated for longitudinal quantification of brain structure from infancy to early adulthood in a mouse model of Sanfilippo syndrome (mucopolysaccharidosis type III), generated by knockout of the Hgsnat gene. We find that Hgsnat(-/-) mice have regionally …
The approach is demonstrated for longitudinal quantification of brain structure from infancy to early adulthood in a mouse model of S …
Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid.
Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T, Ambasudhan R, McKercher SR, Masliah E, Lipton SA. Zhang D, et al. J Neurochem. 2015 Jun;133(6):898-908. doi: 10.1111/jnc.13074. Epub 2015 Mar 11. J Neurochem. 2015. PMID: 25692407 Free PMC article.
Here, as a potential preemptive countermeasure against a bioterrorist attack with cyanide, we tested the CNS protective effect of carnosic acid (CA), a pro-electrophilic compound found in the herb rosemary. CA crosses the blood-brain barrier to up-regulate endogenous antio …
Here, as a potential preemptive countermeasure against a bioterrorist attack with cyanide, we tested the CNS protective effect of carnosic a …
Quantitative Immunohistochemistry to Measure Regional Expression of Nurr1 in the Brain and the Effect of the Nurr1 Heterozygous Genotype.
Kummari E, Guo-Ross SX, Partington HS, Nutter JM, Eells JB. Kummari E, et al. Front Neuroanat. 2021 Apr 30;15:563854. doi: 10.3389/fnana.2021.563854. eCollection 2021. Front Neuroanat. 2021. PMID: 33994958 Free PMC article.
Additionally, neuronal Nurr1 expression levels were compared between different brain regions in wild-type mice (+/+) and Nurr1 heterozygous mice (+/-). ...Nurr1 protein is expressed in various regions throughout the brain, however, a wide range of Nurr1 expression l …
Additionally, neuronal Nurr1 expression levels were compared between different brain regions in wild-type mice (+/+) and Nurr1 hetero …
HYPO-CHEAT's aggregated weekly visualisations of risk reduce real world hypoglycaemia.
Worth C, Nutter PW, Dunne MJ, Salomon-Estebanez M, Banerjee I, Harper S. Worth C, et al. Digit Health. 2022 Oct 17;8:20552076221129712. doi: 10.1177/20552076221129712. eCollection 2022 Jan-Dec. Digit Health. 2022. PMID: 36276186 Free PMC article.
BACKGROUND: Children with congenital hyperinsulinism (CHI) are at constant risk of hypoglycaemia with the attendant risk of brain injury. Current hypoglycaemia prevention methods centre on the prediction of a continuous glucose variable using machine learning (ML) processi …
BACKGROUND: Children with congenital hyperinsulinism (CHI) are at constant risk of hypoglycaemia with the attendant risk of brain inj …
Brain structure variation in great apes, with attention to the mountain gorilla (Gorilla beringei beringei).
Sherwood CC, Cranfield MR, Mehlman PT, Lilly AA, Garbe JA, Whittier CA, Nutter FB, Rein TR, Bruner HJ, Holloway RL, Tang CY, Naidich TP, Delman BN, Steklis HD, Erwin JM, Hof PR. Sherwood CC, et al. Am J Primatol. 2004 Jul;63(3):149-64. doi: 10.1002/ajp.20048. Am J Primatol. 2004. PMID: 15258959
This report presents data regarding the brain structure of mountain gorillas (Gorilla beringei beringei) in comparison with other great apes. ...The loadings on PCs indicated that the brain structure of great apes differs among taxa mostly in the relative sizes of t …
This report presents data regarding the brain structure of mountain gorillas (Gorilla beringei beringei) in comparison with other gre …
The behaviour change behind a successful pilot of hypoglycaemia reduction with HYPO-CHEAT.
Worth C, Nutter PW, Salomon-Estebanez M, Auckburally S, Dunne MJ, Banerjee I, Harper S. Worth C, et al. Digit Health. 2023 Aug 3;9:20552076231192011. doi: 10.1177/20552076231192011. eCollection 2023 Jan-Dec. Digit Health. 2023. PMID: 37545627 Free PMC article.
BACKGROUND: Children with hypoglycaemia disorders, such as congenital hyperinsulinism (CHI), are at constant risk of hypoglycaemia (low blood sugars) with the attendant risk of brain injury. Current approaches to hypoglycaemia detection and prevention vary from fingerprick …
BACKGROUND: Children with hypoglycaemia disorders, such as congenital hyperinsulinism (CHI), are at constant risk of hypoglycaemia (low bloo …
35 results