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SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution.
Maraschi A, Gumina V, Dragotto J, Colombrita C, Mompeán M, Buratti E, Silani V, Feligioni M, Ratti A. Maraschi A, et al. Mol Neurobiol. 2021 Nov;58(11):5682-5702. doi: 10.1007/s12035-021-02505-8. Epub 2021 Aug 14. Mol Neurobiol. 2021. PMID: 34390468 Free PMC article.
The nuclear RNA-binding protein TDP-43 forms abnormal cytoplasmic aggregates in the brains of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients and several molecular mechanisms promoting TDP-43 cytoplasmic mislocalization and aggregation have b …
The nuclear RNA-binding protein TDP-43 forms abnormal cytoplasmic aggregates in the brains of amyotrophic lateral sclerosis (ALS) and …
TDP-43 and NOVA-1 RNA-binding proteins as competitive splicing regulators of the schizophrenia-associated TNIK gene.
Gumina V, Colombrita C, Fallini C, Bossolasco P, Maraschi AM, Landers JE, Silani V, Ratti A. Gumina V, et al. Biochim Biophys Acta Gene Regul Mech. 2019 Sep;1862(9):194413. doi: 10.1016/j.bbagrm.2019.194413. Epub 2019 Aug 2. Biochim Biophys Acta Gene Regul Mech. 2019. PMID: 31382054 Free PMC article.
Here we show that in the human adult nervous system TNIK exon 15 is mostly included compared to the other tissues and that, during neuronal differentiation of human induced pluripotent stem cells and of human neuroblastoma cells, TNIK exon 15 inclusion increases independently of …
Here we show that in the human adult nervous system TNIK exon 15 is mostly included compared to the other tissues and that, during neuronal …
Inter-Species Differences in Regulation of the Progranulin-Sortilin Axis in TDP-43 Cell Models of Neurodegeneration.
Gumina V, Onesto E, Colombrita C, Maraschi A, Silani V, Ratti A. Gumina V, et al. Int J Mol Sci. 2019 Nov 22;20(23):5866. doi: 10.3390/ijms20235866. Int J Mol Sci. 2019. PMID: 31766750 Free PMC article.
Cytoplasmic aggregates and nuclear depletion of the ubiquitous RNA-binding protein TDP-43 have been described in the autoptic brain tissues of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTLD) patients and both TDP-43 loss-of-function and gain-of-funct …
Cytoplasmic aggregates and nuclear depletion of the ubiquitous RNA-binding protein TDP-43 have been described in the autoptic brain t …
Neuregulin-1β induces proliferation, survival and paracrine signaling in normal human cardiac ventricular fibroblasts.
Kirabo A, Ryzhov S, Gupte M, Sengsayadeth S, Gumina RJ, Sawyer DB, Galindo CL. Kirabo A, et al. J Mol Cell Cardiol. 2017 Apr;105:59-69. doi: 10.1016/j.yjmcc.2017.03.001. Epub 2017 Mar 3. J Mol Cell Cardiol. 2017. PMID: 28263756 Free PMC article.
NRG-1beta also induced production and secretion of cytokines (interleukin-1alpha and interferon-gamma) and pro-reparative factors (angiopoietin-2, brain-derived neurotrophic factor, and crypto-1), suggesting a role in cardiac repair through the activation of paracrine sign …
NRG-1beta also induced production and secretion of cytokines (interleukin-1alpha and interferon-gamma) and pro-reparative factors (angiopoie …