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Year Number of Results
1990 1
1995 1
1996 2
1997 2
1998 5
2000 2
2001 5
2002 6
2003 16
2004 7
2005 18
2006 12
2007 10
2008 12
2009 18
2010 25
2011 23
2012 28
2013 35
2014 44
2015 52
2016 63
2017 55
2018 46
2019 59
2020 60
2021 87
2022 75
2023 92
2024 35

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810 results

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Page 1
FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma.
Wang Y, Lyu Z, Qin Y, Wang X, Sun L, Zhang Y, Gong L, Wu S, Han S, Tang Y, Jia Y, Kwong DL, Kam N, Guan XY. Wang Y, et al. Theranostics. 2020 Sep 16;10(25):11535-11548. doi: 10.7150/thno.45261. eCollection 2020. Theranostics. 2020. PMID: 33052231 Free PMC article.
Objective: The transcription factor forkhead box protein O1 (FOXO1) is critical for regulating cytokine and chemokine secretion. ...
Objective: The transcription factor forkhead box protein O1 (FOXO1) is critical for regulating cytokine and chemokine secretion. ...
Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models.
Feng D, Xiang X, Guan Y, Guillot A, Lu H, Chang C, He Y, Wang H, Pan H, Ju C, Colgan SP, Tacke F, Wang XW, Kunos G, Gao B. Feng D, et al. J Clin Invest. 2023 Aug 1;133(15):e166954. doi: 10.1172/JCI166954. J Clin Invest. 2023. PMID: 37338984 Free PMC article.
At the early stage of injury, infiltrating MoMFs activated the Jagged1/notch homolog protein 2 (JAG1/NOTCH2) axis to induce cell death-resistant SRY-box transcription factor 9+ (SOX9+) hepatocytes near the necrotic lesions, which acted as a barrier from further injury. ...
At the early stage of injury, infiltrating MoMFs activated the Jagged1/notch homolog protein 2 (JAG1/NOTCH2) axis to induce cell death-resis …
c-Myc-Targeting PROTAC Based on a TNA-DNA Bivalent Binder for Combination Therapy of Triple-Negative Breast Cancer.
Li X, Zhang Z, Gao F, Ma Y, Wei D, Lu Z, Chen S, Wang M, Wang Y, Xu K, Wang R, Xu F, Chen JY, Zhu C, Li Z, Yu H, Guan X. Li X, et al. J Am Chem Soc. 2023 Apr 26;145(16):9334-9342. doi: 10.1021/jacs.3c02619. Epub 2023 Apr 17. J Am Chem Soc. 2023. PMID: 37068218
The TNA aptamer is selected in vitro to bind the c-Myc/Max heterodimer and appended to the E-box DNA sequence to create a high-affinity, biologically stable bivalent binder. The TNA-E box-pomalidomide (TEP) conjugate specifically degrades endogenous c-Myc/Max, inhib …
The TNA aptamer is selected in vitro to bind the c-Myc/Max heterodimer and appended to the E-box DNA sequence to create a high-affini …
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis.
He T, Shang J, Gao C, Guan X, Chen Y, Zhu L, Zhang L, Zhang C, Zhang J, Pang T. He T, et al. Acta Pharm Sin B. 2021 Mar;11(3):708-726. doi: 10.1016/j.apsb.2020.11.002. Epub 2020 Nov 7. Acta Pharm Sin B. 2021. PMID: 33777677 Free PMC article.
Here, we designed a novel SIRT6 activator MDL-811 which remarkably inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and primary mouse microglia, which were abolished by silencing SIRT6. RNA-seq screening identified the forkhead box …
Here, we designed a novel SIRT6 activator MDL-811 which remarkably inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RA …
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Qian Y, Arellano G, Ifergan I, Lin J, Snowden C, Kim T, Thomas JJ, Law C, Guan T, Balabanov RD, Kaech SM, Miller SD, Choi J. Qian Y, et al. Cell Rep. 2021 Aug 24;36(8):109602. doi: 10.1016/j.celrep.2021.109602. Cell Rep. 2021. PMID: 34433042 Free PMC article.
To identify disease-relevant regulators of T cell fate, we examined mutations that modify risk for multiple sclerosis (MS), a canonical organ-specific autoimmune disease. This analysis identified a role for Zinc finger E-box-binding homeobox (ZEB1). Deletion of ZEB1 protec …
To identify disease-relevant regulators of T cell fate, we examined mutations that modify risk for multiple sclerosis (MS), a canonical orga …
Dissecting multifunctional roles of forkhead box transcription factor D1 in cancers.
Cheng L, Yan H, Liu Y, Guan G, Cheng P. Cheng L, et al. Biochim Biophys Acta Rev Cancer. 2023 Nov;1878(6):188986. doi: 10.1016/j.bbcan.2023.188986. Epub 2023 Sep 15. Biochim Biophys Acta Rev Cancer. 2023. PMID: 37716516 Review.
As a member of the forkhead box (FOX) family of transcription factors (TF), FOXD1 has recently been implicated as a crucial regulator in a variety of human cancers. ...
As a member of the forkhead box (FOX) family of transcription factors (TF), FOXD1 has recently been implicated as a crucial regulator …
Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective.
Wang S, Guan YG, Zhu YH, Wang MZ. Wang S, et al. World J Psychiatry. 2022 Jun 19;12(6):779-786. doi: 10.5498/wjp.v12.i6.779. eCollection 2022 Jun 19. World J Psychiatry. 2022. PMID: 35978968 Free PMC article. Review.
Recent studies demonstrated that neuroinflammation activation plays an important role in the pathophysiology of depression. In this respect, high mobility group box 1 (HMGB1) may be a possible signaling inducer of neuroinflammation and can be a potential mechanistic and th …
Recent studies demonstrated that neuroinflammation activation plays an important role in the pathophysiology of depression. In this respect, …
Characterization of the MADS-Box Gene Family in Akebia trifoliata and Their Evolutionary Events in Angiosperms.
Zhong S, Yang H, Guan J, Shen J, Ren T, Li Z, Tan F, Li Q, Luo P. Zhong S, et al. Genes (Basel). 2022 Oct 1;13(10):1777. doi: 10.3390/genes13101777. Genes (Basel). 2022. PMID: 36292662 Free PMC article.
To study the early evolution of angiosperms, we identified and characterized the MADS-Box gene family on the whole-genome level of A. trifoliata. There were 47 MADS-box genes (13 type I and 34 type II genes) in the A. trifoliata genome; type I genes had a greater ge …
To study the early evolution of angiosperms, we identified and characterized the MADS-Box gene family on the whole-genome level of A. …
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy.
Guan S, Chen X, Chen Y, Wan G, Su Q, Liang H, Yang Y, Fang W, Huang Y, Zhao H, Zhuang W, Liu S, Wang F, Feng W, Zhang X, Huang M, Wang X, Zhang L. Guan S, et al. Acta Pharm Sin B. 2022 Sep;12(9):3639-3649. doi: 10.1016/j.apsb.2022.02.006. Epub 2022 Feb 15. Acta Pharm Sin B. 2022. PMID: 36176901 Free PMC article.
Here, we found that patients with rs4946935 AA, located in Forkhead Box O3 (FOXO3) which is a well-known autophagic regulator, had a higher risk of hepatotoxicity than those with the GA or GG variant (OR = 18.020, 95%CI = 2.473 to 459.1784, P = 0.018) in a gefitinib-concen …
Here, we found that patients with rs4946935 AA, located in Forkhead Box O3 (FOXO3) which is a well-known autophagic regulator, had a …
810 results