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Showing results for bingeing, gao
Search for bingbing, gao instead (1 results)
Mouse model of chronic and binge ethanol feeding (the NIAAA model).
Bertola A, Mathews S, Ki SH, Wang H, Gao B. Bertola A, et al. Nat Protoc. 2013 Mar;8(3):627-37. doi: 10.1038/nprot.2013.032. Epub 2013 Feb 28. Nat Protoc. 2013. PMID: 23449255 Free PMC article.
Here we describe a simple mouse model of alcoholic liver injury by chronic ethanol feeding (10-d ad libitum oral feeding with the Lieber-DeCarli ethanol liquid diet) plus a single binge ethanol feeding. This protocol for chronic-plus-single-binge ethanol feeding syn …
Here we describe a simple mouse model of alcoholic liver injury by chronic ethanol feeding (10-d ad libitum oral feeding with the Lieber-DeC …
Current Discoveries and Future Implications of Eating Disorders.
Feng B, Harms J, Chen E, Gao P, Xu P, He Y. Feng B, et al. Int J Environ Res Public Health. 2023 Jul 8;20(14):6325. doi: 10.3390/ijerph20146325. Int J Environ Res Public Health. 2023. PMID: 37510558 Free PMC article. Review.
Common eating disorders have three major types: anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). In some cases, EDs can have serious consequences for an individual's physical and mental health. ...
Common eating disorders have three major types: anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). In some …
Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis.
Chao X, Wang S, Ma X, Zhang C, Qian H, Williams SN, Sun Z, Peng Z, Liu W, Li F, Sheshadri N, Zong WX, Ni HM, Ding WX. Chao X, et al. Hepatology. 2023 Aug 1;78(2):503-517. doi: 10.1097/HEP.0000000000000373. Epub 2023 Apr 1. Hepatology. 2023. PMID: 36999531
Gao-binge alcohol markedly increased liver/body weight ratio and serum alanine aminotransferase levels in L- Tsc1 KO mice compared with Gao-binge alcohol-fed wild-type mice. ...Gao-binge alcohol-fed L- Tsc1 KO mice also developed severe i …
Gao-binge alcohol markedly increased liver/body weight ratio and serum alanine aminotransferase levels in L- Tsc1 KO mice comp …
Macrophage-derived MLKL in alcohol-associated liver disease: Regulation of phagocytosis.
Wu X, Fan X, McMullen MR, Miyata T, Kim A, Pathak V, Wu J, Day LZ, Hardesty JE, Welch N, Dasarathy J, Allende DS, McCullough AJ, Jacobs JM, Rotroff DM, Dasarathy S, Nagy LE. Wu X, et al. Hepatology. 2023 Mar 1;77(3):902-919. doi: 10.1002/hep.32612. Epub 2023 Feb 17. Hepatology. 2023. PMID: 35689613 Free PMC article.
APPROACH AND RESULTS: Bone marrow transplants between Mlkl-/- mice and littermates were conducted to distinguish the role of myeloid versus nonmyeloid Mlkl in the Gao-binge model of ALD. Ethanol-induced hepatic injury, steatosis, and inflammation were exacerbated in …
APPROACH AND RESULTS: Bone marrow transplants between Mlkl-/- mice and littermates were conducted to distinguish the role of myeloid versus …
Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure.
Ma J, Guillot A, Yang Z, Mackowiak B, Hwang S, Park O, Peiffer BJ, Ahmadi AR, Melo L, Kusumanchi P, Huda N, Saxena R, He Y, Guan Y, Feng D, Sancho-Bru P, Zang M, Cameron AM, Bataller R, Tacke F, Sun Z, Liangpunsakul S, Gao B. Ma J, et al. J Clin Invest. 2022 Jul 15;132(14):e157780. doi: 10.1172/JCI157780. J Clin Invest. 2022. PMID: 35838051 Free PMC article.
To study specifically the mechanisms related to Neuhi in AH patients and liver injury, we used the mouse model of chronic-plus-binge ethanol feeding and found that myeloid-specific deletion of the Ncf1 gene abolished ethanol-induced hepatic inflammation and steatosis. ...
To study specifically the mechanisms related to Neuhi in AH patients and liver injury, we used the mouse model of chronic-plus-binge …
Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C/EBPα-miRNA-223 axis.
Ren R, He Y, Ding D, Cui A, Bao H, Ma J, Hou X, Li Y, Feng D, Li X, Liangpunsakul S, Gao B, Wang H. Ren R, et al. Hepatology. 2022 Mar;75(3):646-660. doi: 10.1002/hep.32152. Epub 2021 Dec 5. Hepatology. 2022. PMID: 34510484 Free PMC article.
APPROACH AND RESULTS: Young and aged myeloid-specific Sirt1 knockout mice were subjected to chronic-plus-binge ethanol feeding. Blood samples from healthy controls and patients with chronic alcohol drinking who presented with acute intoxication were analyzed. ...Deletion o …
APPROACH AND RESULTS: Young and aged myeloid-specific Sirt1 knockout mice were subjected to chronic-plus-binge ethanol feeding. Blood …
Verbenalin attenuates hepatic damage and mitochondrial dysfunction in alcohol-associated steatohepatitis by regulating MDMX/PPARα-mediated ferroptosis.
Dong J, Du C, Xu C, Wang Q, Wang Z, Zhu Q, Lv X, Zhang L, Li J, Huang C, Wang H, Ma T. Dong J, et al. J Ethnopharmacol. 2023 May 10;307:116227. doi: 10.1016/j.jep.2023.116227. Epub 2023 Feb 3. J Ethnopharmacol. 2023. PMID: 36739928
MATERIAL AND METHODS: C57BL/6 mice treated with alcohol followed by the Gao-Binge protocol were administered verbenalin by gavage simultaneously. ...
MATERIAL AND METHODS: C57BL/6 mice treated with alcohol followed by the Gao-Binge protocol were administered verbenalin by gav …
Targeting hepatic serine-arginine protein kinase 2 ameliorates alcohol-associated liver disease by alternative splicing control of lipogenesis.
Li G, Chen H, Shen F, Smithson SB, Shealy GL, Ping Q, Liang Z, Han J, Adams AC, Li Y, Feng D, Gao B, Morita M, Han X, Huang TH, Musi N, Zang M. Li G, et al. Hepatology. 2023 Nov 1;78(5):1506-1524. doi: 10.1097/HEP.0000000000000433. Epub 2023 May 3. Hepatology. 2023. PMID: 37129868
APPROACH AND RESULTS: Serine-arginine-rich protein kinase 2 (SRPK2), a key kinase controlling alternative splicing, is activated in hepatocytes in response to alcohol, in mice with chronic-plus-binge alcohol feeding, and in patients with ALD. Such induction activates stero …
APPROACH AND RESULTS: Serine-arginine-rich protein kinase 2 (SRPK2), a key kinase controlling alternative splicing, is activated in hepatocy …
Ethanol and its Nonoxidative Metabolites Promote Acute Liver Injury by Inducing ER Stress, Adipocyte Death, and Lipolysis.
Park SH, Seo W, Xu MJ, Mackowiak B, Lin Y, He Y, Fu Y, Hwang S, Kim SJ, Guan Y, Feng D, Yu L, Lehner R, Liangpunsakul S, Gao B. Park SH, et al. Cell Mol Gastroenterol Hepatol. 2023;15(2):281-306. doi: 10.1016/j.jcmgh.2022.10.002. Epub 2022 Oct 13. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36243320 Free PMC article.
BACKGROUND & AIMS: Binge drinking in patients with metabolic syndrome accelerates the development of alcohol-associated liver disease. ...We investigated if oxidative and nonoxidative alcohol metabolism pathways, diet-induced obesity, and adipose tissues influenced the …
BACKGROUND & AIMS: Binge drinking in patients with metabolic syndrome accelerates the development of alcohol-associated liver dis …
Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice.
Hendrikx T, Duan Y, Wang Y, Oh JH, Alexander LM, Huang W, Stärkel P, Ho SB, Gao B, Fiehn O, Emond P, Sokol H, van Pijkeren JP, Schnabl B. Hendrikx T, et al. Gut. 2019 Aug;68(8):1504-1515. doi: 10.1136/gutjnl-2018-317232. Epub 2018 Nov 17. Gut. 2019. PMID: 30448775 Free PMC article.
Therefore, we investigated the role of IL-22 in mice subjected to chronic-binge ethanol feeding (NIAAA model). RESULTS: In a mouse model of alcoholic liver disease, we found that type 3 innate lymphoid cells produce lower levels of IL-22. ...
Therefore, we investigated the role of IL-22 in mice subjected to chronic-binge ethanol feeding (NIAAA model). RESULTS: In a mouse mo …
114 results