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Year Number of Results
1982 1
1983 2
1984 1
1985 6
1986 1
1987 1
1988 4
1989 14
1990 19
1991 29
1992 30
1993 57
1994 94
1995 116
1996 121
1997 122
1998 159
1999 168
2000 197
2001 213
2002 281
2003 352
2004 360
2005 472
2006 583
2007 665
2008 691
2009 795
2010 1006
2011 1107
2012 1316
2013 1635
2014 1878
2015 2011
2016 2025
2017 2264
2018 2561
2019 2863
2020 3326
2021 3554
2022 3766
2023 3591
2024 1772

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35,792 results

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Page 1
Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants.
Zhao Z, Xie Y, Bai B, Luo C, Zhou J, Li W, Meng Y, Li L, Li D, Li X, Li X, Wang X, Sun J, Xu Z, Sun Y, Zhang W, Fan Z, Zhao X, Wu L, Ma J, Li OY, Shang G, Chai Y, Liu K, Wang P, Gao GF, Qi J. Zhao Z, et al. Nat Commun. 2023 Jul 21;14(1):4405. doi: 10.1038/s41467-023-39942-z. Nat Commun. 2023. PMID: 37479708 Free PMC article.
Additionally, BA.2.75 is significantly increasing in some countries. Exploring their receptor binding and interspecies transmission risk is urgently needed. Herein, we examine the binding capacities of human and other 28 animal ACE2 orthologs covering nine orders to …
Additionally, BA.2.75 is significantly increasing in some countries. Exploring their receptor binding and interspecies transmission r …
Tail engagement of arrestin at the glucagon receptor.
Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B. Chen K, et al. Nature. 2023 Aug;620(7975):904-910. doi: 10.1038/s41586-023-06420-x. Epub 2023 Aug 9. Nature. 2023. PMID: 37558880 Free PMC article.
Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by desensitizing G protein activation and mediating receptor internalization(1,2). It has been proposed that the arrestin binds to the receptor in two different conformations, 'tail' an …
Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by desensitizing G protein activation and mediating …
Aptamer binding assays and molecular interaction studies using fluorescence anisotropy - A review.
Zhao Q, Tao J, Feng W, Uppal JS, Peng H, Le XC. Zhao Q, et al. Anal Chim Acta. 2020 Aug 15;1125:267-278. doi: 10.1016/j.aca.2020.05.061. Epub 2020 May 28. Anal Chim Acta. 2020. PMID: 32674773 Review.
We review recent advances in affinity binding assays using aptamers and FA/FP, with an emphasis on studies of molecular interactions and identification of binding sites. Aptamers provide several benefits, including the ease of labelling fluorophores on specific site …
We review recent advances in affinity binding assays using aptamers and FA/FP, with an emphasis on studies of molecular interactions …
Effect of Sex Hormone-Binding Globulin on Polycystic Ovary Syndrome: Mechanisms, Manifestations, Genetics, and Treatment.
Xing C, Zhang J, Zhao H, He B. Xing C, et al. Int J Womens Health. 2022 Feb 2;14:91-105. doi: 10.2147/IJWH.S344542. eCollection 2022. Int J Womens Health. 2022. PMID: 35140526 Free PMC article. Review.
Most women with PCOS have metabolic abnormalities. Sex hormone-binding globulin (SHBG), a transport carrier that binds estrogen and androgens and regulates their biological activity, is usually used as an indicator of hyperandrogenism in women with PCOS. ...
Most women with PCOS have metabolic abnormalities. Sex hormone-binding globulin (SHBG), a transport carrier that binds estroge …
The molecular basis of tight nuclear tethering and inactivation of cGAS.
Zhao B, Xu P, Rowlett CM, Jing T, Shinde O, Lei Y, West AP, Liu WR, Li P. Zhao B, et al. Nature. 2020 Nov;587(7835):673-677. doi: 10.1038/s41586-020-2749-z. Epub 2020 Sep 10. Nature. 2020. PMID: 32911481 Free PMC article.
High-affinity nucleosome binding blocks double-stranded DNA binding and maintains cGAS in an inactive conformation. Mutations of cGAS that disrupt nucleosome binding alter cGAS-mediated signalling in cells....
High-affinity nucleosome binding blocks double-stranded DNA binding and maintains cGAS in an inactive conformation. Mutations …
Study on the binding of ningnanmycin to the helicase of Tobamovirus virus.
Wang C, Ma G, Zhang S, Zhao K, Li X. Wang C, et al. Pestic Biochem Physiol. 2023 Aug;194:105494. doi: 10.1016/j.pestbp.2023.105494. Epub 2023 Jun 10. Pestic Biochem Physiol. 2023. PMID: 37532353
In this study, we expressed and purified several Tobamovirus virus helicase proteins and analyzed the three-dimensional structures of several Tobamovirus virus helicases. In addition, the binding of Tobamovirus helicase to NNM was also studied. The docking study reveals th …
In this study, we expressed and purified several Tobamovirus virus helicase proteins and analyzed the three-dimensional structures of severa …
DeepBtoD: Improved RNA-binding proteins prediction via integrated deep learning.
Du X, Zhao X, Zhang Y. Du X, et al. J Bioinform Comput Biol. 2022 Aug;20(4):2250006. doi: 10.1142/S0219720022500068. Epub 2022 Apr 21. J Bioinform Comput Biol. 2022. PMID: 35451938
RNA-binding proteins (RBPs) have crucial roles in various cellular processes such as alternative splicing and gene regulation. ...Finally, global information is considered to supplement local modules with ensemble learning to predict whether the target RNA binds to …
RNA-binding proteins (RBPs) have crucial roles in various cellular processes such as alternative splicing and gene regulation. ...Fin …
Structural basis of AlpA-dependent transcription antitermination.
Wen A, Zhao M, Jin S, Lu YQ, Feng Y. Wen A, et al. Nucleic Acids Res. 2022 Aug 12;50(14):8321-8330. doi: 10.1093/nar/gkac608. Nucleic Acids Res. 2022. PMID: 35871295 Free PMC article.
AlpA positively regulates a programmed cell death pathway linked to the virulence of Pseudomonas aeruginosa by recognizing an AlpA binding element within the promoter, then binding RNA polymerase directly and allowing it to bypass an intrinsic terminator positioned …
AlpA positively regulates a programmed cell death pathway linked to the virulence of Pseudomonas aeruginosa by recognizing an AlpA bindin …
Identification and Comparison of the Sialic Acid-Binding Domain Characteristics of Avian Coronavirus Infectious Bronchitis Virus Spike Protein.
You R, Liu K, Huang M, Tang L, Zhang X, Huang Y, Zhao J, Zhao Y, Ye L, Zhang G. You R, et al. J Virol. 2023 May 31;97(5):e0048923. doi: 10.1128/jvi.00489-23. Epub 2023 Apr 25. J Virol. 2023. PMID: 37097156 Free PMC article.
Infectious bronchitis virus (IBV) infections are initiated by the transmembrane spike (S) glycoprotein, which binds to host factors and fuses the viral and cell membranes. The N-terminal domain of the S1 subunit of IBV S protein binds to sialic acids, but the precis …
Infectious bronchitis virus (IBV) infections are initiated by the transmembrane spike (S) glycoprotein, which binds to host factors a …
Mechanism of histone H2B monoubiquitination by Bre1.
Zhao F, Hicks CW, Wolberger C. Zhao F, et al. Nat Struct Mol Biol. 2023 Nov;30(11):1623-1627. doi: 10.1038/s41594-023-01137-x. Epub 2023 Oct 23. Nat Struct Mol Biol. 2023. PMID: 37872231
The structure of a nucleosome in complex with the dimeric RING E3 ligase Bre1 reveals that one RING domain binds to the nucleosome acidic patch, where it can position the E2 ubiquitin conjugating enzyme Rad6, while the other RING domain contacts the DNA. Comparisons with H …
The structure of a nucleosome in complex with the dimeric RING E3 ligase Bre1 reveals that one RING domain binds to the nucleosome ac …
35,792 results
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