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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1969 1
1971 1
1973 1
1974 3
1975 2
1976 2
1977 3
1978 2
1979 3
1980 8
1981 6
1982 6
1983 6
1984 6
1985 8
1986 8
1987 11
1988 13
1989 13
1990 19
1991 18
1992 24
1993 21
1994 56
1995 45
1996 55
1997 63
1998 68
1999 70
2000 96
2001 102
2002 128
2003 183
2004 192
2005 249
2006 253
2007 292
2008 344
2009 342
2010 418
2011 488
2012 577
2013 646
2014 716
2015 783
2016 836
2017 845
2018 957
2019 1104
2020 1250
2021 1338
2022 1456
2023 1359
2024 657

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14,424 results

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Did you mean binding we (1,784,147 results)?
A gut-derived hormone regulates cholesterol metabolism.
Hu X, Chen F, Jia L, Long A, Peng Y, Li X, Huang J, Wei X, Fang X, Gao Z, Zhang M, Liu X, Chen YG, Wang Y, Zhang H, Wang Y. Hu X, et al. Cell. 2024 Mar 28;187(7):1685-1700.e18. doi: 10.1016/j.cell.2024.02.024. Epub 2024 Mar 18. Cell. 2024. PMID: 38503280
It is secreted from the intestine in response to cholesterol absorption and binds to GPR146, an orphan G-protein-coupled receptor, exerting antagonistic downstream effects by inhibiting PKA signaling and thereby suppressing SREBP2-controlled cholesterol synthesis in the li …
It is secreted from the intestine in response to cholesterol absorption and binds to GPR146, an orphan G-protein-coupled receptor, ex …
HSPA8 regulates anti-bacterial autophagy through liquid-liquid phase separation.
Miao C, Zhang Y, Yu M, Wei Y, Dong C, Pei G, Xiao Y, Yang J, Yao Z, Wang Q. Miao C, et al. Autophagy. 2023 Oct;19(10):2702-2718. doi: 10.1080/15548627.2023.2223468. Epub 2023 Jun 13. Autophagy. 2023. PMID: 37312409
HSPA8 (heat shock protein family A (Hsp70) member 8) plays a significant role in the autophagic degradation of proteins, however, its effect on protein stabilization and anti-bacterial autophagy remains unknown. Here, it is discovered that HSPA8, as a binding partner of RH …
HSPA8 (heat shock protein family A (Hsp70) member 8) plays a significant role in the autophagic degradation of proteins, however, its effect …
Lactate fuels mitosis.
Dai X, Wei W. Dai X, et al. Mol Cell. 2023 May 18;83(10):1549-1551. doi: 10.1016/j.molcel.2023.04.013. Mol Cell. 2023. PMID: 37207623 Free PMC article.
Liu et al.(1) reveal that glycolysis end-product lactate directly binds and inhibits the SUMO protease SENP1 to govern the E3 ligase activity of the anaphase-promoting complex, leading to efficient mitotic exit in proliferative cells....
Liu et al.(1) reveal that glycolysis end-product lactate directly binds and inhibits the SUMO protease SENP1 to govern the E3 ligase …
SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.
Schmidt N, Ganskih S, Wei Y, Gabel A, Zielinski S, Keshishian H, Lareau CA, Zimmermann L, Makroczyova J, Pearce C, Krey K, Hennig T, Stegmaier S, Moyon L, Horlacher M, Werner S, Aydin J, Olguin-Nava M, Potabattula R, Kibe A, Dölken L, Smyth RP, Caliskan N, Marsico A, Krempl C, Bodem J, Pichlmair A, Carr SA, Chlanda P, Erhard F, Munschauer M. Schmidt N, et al. Cell. 2023 Oct 26;186(22):4834-4850.e23. doi: 10.1016/j.cell.2023.09.002. Epub 2023 Oct 3. Cell. 2023. PMID: 37794589 Free PMC article.
Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To characterize host RNA-binding proteins (RBPs) involved in this process, we biochemically identified proteins bound to genomic and subgenomic SARS-CoV-2 RNAs. We find that the host prot …
Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To characterize host RNA-binding proteins (RBPs …
IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.
Jiang Z, Wei F, Zhang Y, Wang T, Gao W, Yu S, Sun H, Pu J, Sun Y, Wang M, Tong Q, Gao C, Chang KC, Liu J. Jiang Z, et al. Nat Microbiol. 2021 Jul;6(7):932-945. doi: 10.1038/s41564-021-00907-x. Epub 2021 May 13. Nat Microbiol. 2021. PMID: 33986530
IFI16 positively upregulates RIG-I transcription through direct binding to and recruitment of RNA polymerase II to the RIG-I promoter. IFI16 also binds to influenza viral RNA via its HINa domain and to RIG-I protein with its PYRIN domain, thus promoting IAV-induced …
IFI16 positively upregulates RIG-I transcription through direct binding to and recruitment of RNA polymerase II to the RIG-I promoter …
The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.
Han J, Li E, Chen L, Zhang Y, Wei F, Liu J, Deng H, Wang Y. Han J, et al. Nature. 2015 Aug 13;524(7564):243-6. doi: 10.1038/nature14557. Epub 2015 Jul 6. Nature. 2015. PMID: 26147081
Abnormal accumulation of triglycerides in the liver, caused in part by increased de novo lipogenesis, results in non-alcoholic fatty liver disease and insulin resistance. Sterol regulatory element-binding protein 1 (SREBP1), an important transcriptional regulator of lipoge …
Abnormal accumulation of triglycerides in the liver, caused in part by increased de novo lipogenesis, results in non-alcoholic fatty liver d …
The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Lian H, Zang R, Wei J, Ye W, Hu MM, Chen YD, Zhang XN, Guo Y, Lei CQ, Yang Q, Luo WW, Li S, Shu HB. Lian H, et al. Immunity. 2018 Sep 18;49(3):438-448.e5. doi: 10.1016/j.immuni.2018.08.014. Epub 2018 Sep 4. Immunity. 2018. PMID: 30193849 Free article.
Recognition of viral RNA by the retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) initiates innate antiviral immune response. How the binding of viral RNA to and activation of the RLRs are regulated remains enigmatic. ...ZCCHC3 was associated with RIG-I and MDA5 …
Recognition of viral RNA by the retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) initiates innate antiviral immune response. How …
PTBP1 as a potential regulator of disease.
Yu Q, Wu T, Xu W, Wei J, Zhao A, Wang M, Li M, Chi G. Yu Q, et al. Mol Cell Biochem. 2023 Dec 22. doi: 10.1007/s11010-023-04905-x. Online ahead of print. Mol Cell Biochem. 2023. PMID: 38129625 Review.
Polypyrimidine tract-binding protein 1 (PTBP1) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a key role in alternative splicing of precursor mRNA and RNA metabolism. PTBP1 is universally expressed in various tissues and binds …
Polypyrimidine tract-binding protein 1 (PTBP1) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays …
Structure-based mechanisms of 2'3'-cGAMP intercellular transport in the cGAS-STING immune pathway.
Xie W, Patel DJ. Xie W, et al. Trends Immunol. 2023 Jun;44(6):450-467. doi: 10.1016/j.it.2023.04.006. Epub 2023 May 4. Trends Immunol. 2023. PMID: 37147228 Review.
Upon activation by double-stranded DNA (dsDNA), the cytosolic dsDNA sensor cyclic GMP-AMP synthase (cGAS) synthesizes the diffusible cyclic dinucleotide 2'3'-cGAMP (cyclic GMP-AMP), which subsequently binds to the adaptor STING, triggering a cascade of events leading to an …
Upon activation by double-stranded DNA (dsDNA), the cytosolic dsDNA sensor cyclic GMP-AMP synthase (cGAS) synthesizes the diffusible cyclic …
MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria-dependent dephosphorylation of EGFR.
Luo L, Wei D, Pan Y, Wang QX, Feng JX, Yu B, Kang T, Luo J, Yang J, Gao S. Luo L, et al. Cancer Commun (Lond). 2023 Jul;43(7):808-833. doi: 10.1002/cac2.12428. Epub 2023 Jun 28. Cancer Commun (Lond). 2023. PMID: 37378422 Free PMC article.
In a kidney-specific knockout mouse model, loss of MFN2 led to EGFR pathway activation and malignant lesions in kidney. Mechanistically, MFN2 preferably binded small GTPase Rab21 in its GTP-loading form, which was colocalized with endocytosed EGFR in ccRCC cells. ...
In a kidney-specific knockout mouse model, loss of MFN2 led to EGFR pathway activation and malignant lesions in kidney. Mechanistically, MFN …
14,424 results
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