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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 5
1981 3
1984 4
1985 9
1986 3
1987 3
1988 9
1989 7
1990 6
1991 12
1992 22
1993 22
1994 30
1995 28
1996 25
1997 36
1998 41
1999 42
2000 54
2001 70
2002 87
2003 102
2004 120
2005 121
2006 131
2007 143
2008 164
2009 196
2010 211
2011 261
2012 328
2013 374
2014 404
2015 503
2016 505
2017 512
2018 567
2019 693
2020 774
2021 912
2022 915
2023 902
2024 452

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8,710 results

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Page 1
N6-methyladenosine-dependent regulation of messenger RNA stability.
Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C. Wang X, et al. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27. Nature. 2014. PMID: 24284625 Free PMC article.
We further establish the role of YTHDF2 in RNA metabolism, showing that binding of YTHDF2 results in the localization of bound mRNA from the translatable pool to mRNA decay sites, such as processing bodies. ...Our results indicate that the dynamic m(6)A modification is rec …
We further establish the role of YTHDF2 in RNA metabolism, showing that binding of YTHDF2 results in the localization of bound mRNA f …
RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.
Qian B, Li Y, Yan R, Han S, Bu Z, Gong J, Zheng B, Yuan Z, Ren S, He Q, Zhang J, Xu C, Wang R, Sun Z, Lin M, Zhou J, Ye L. Qian B, et al. Sci Adv. 2022 Aug 26;8(34):eabq2945. doi: 10.1126/sciadv.abq2945. Epub 2022 Aug 24. Sci Adv. 2022. PMID: 36001654 Free PMC article.
RNA helicase YTHDC2 and its partner MEIOC emerge as essential posttranscriptional regulators of meiotic entry. However, it is unclear what governs the RNA binding specificity of YTHDC2/MEIOC. Here, we identified RNA binding protein RBM46 as a component of the YTHDC2 …
RNA helicase YTHDC2 and its partner MEIOC emerge as essential posttranscriptional regulators of meiotic entry. However, it is unclear what g …
Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance.
Ren C, Han X, Lu C, Yang T, Qiao P, Sun Y, Yu Z. Ren C, et al. Cell Death Differ. 2022 Feb;29(2):381-392. doi: 10.1038/s41418-021-00862-4. Epub 2021 Aug 31. Cell Death Differ. 2022. PMID: 34465889 Free PMC article.
Here, we find that nuclear factor-kB (NF-kappaB) p65 is a new substrate of FBXW2. FBXW2 directly binds to p65, leading to its ubiquitination and degradation. Interestingly, p300 acetylation of p65 blocks FBXW2 induced p65 ubiquitination. ...
Here, we find that nuclear factor-kB (NF-kappaB) p65 is a new substrate of FBXW2. FBXW2 directly binds to p65, leading to its ubiquit …
Actin-Binding Proteins in Cardiac Hypertrophy.
Pan C, Wang S, Liu C, Ren Z. Pan C, et al. Cells. 2022 Nov 11;11(22):3566. doi: 10.3390/cells11223566. Cells. 2022. PMID: 36428995 Free PMC article. Review.
Actin participates in the formation of highly differentiated myofibrils under the regulation of actin-binding proteins (ABPs), which provides a structural basis for the contractile function and morphological change in cardiomyocytes. Previous studies have shown that the fu …
Actin participates in the formation of highly differentiated myofibrils under the regulation of actin-binding proteins (ABPs), which …
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity.
Fixsen BR, Han CZ, Zhou Y, Spann NJ, Saisan P, Shen Z, Balak C, Sakai M, Cobo I, Holtman IR, Warden AS, Ramirez G, Collier JG, Pasillas MP, Yu M, Hu R, Li B, Belhocine S, Gosselin D, Coufal NG, Ren B, Glass CK. Fixsen BR, et al. Nat Immunol. 2023 Jul;24(7):1188-1199. doi: 10.1038/s41590-023-01528-8. Epub 2023 Jun 15. Nat Immunol. 2023. PMID: 37322178 Free PMC article.
SMAD4 binds directly to the Sall1 super-enhancer and is required for Sall1 expression, consistent with an evolutionarily conserved requirement of the TGFbeta and SMAD homologs Dpp and Mad for cell-specific expression of Spalt in the Drosophila wing. Unexpectedly, SALL1 in …
SMAD4 binds directly to the Sall1 super-enhancer and is required for Sall1 expression, consistent with an evolutionarily conserved re …
Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3-FOXO1 in rhabdomyosarcoma.
Sroka MW, Skopelitis D, Vermunt MW, Preall JB, El Demerdash O, de Almeida LMN, Chang K, Utama R, Gryder B, Caligiuri G, Ren D, Nalbant B, Milazzo JP, Tuveson DA, Dobin A, Hiebert SW, Stengel KR, Mantovani R, Khan J, Kohli RM, Shi J, Blobel GA, Vakoc CR. Sroka MW, et al. Proc Natl Acad Sci U S A. 2023 Sep 5;120(36):e2303859120. doi: 10.1073/pnas.2303859120. Epub 2023 Aug 28. Proc Natl Acad Sci U S A. 2023. PMID: 37639593 Free PMC article.
While the transcriptomes of NF-Y- and PAX3-FOXO1-deficient RMS cells bear remarkable similarity to one another, we found that these two transcription factors occupy nonoverlapping sites along the genome: NF-Y preferentially occupies promoters, whereas PAX3-FOXO1 primarily bind …
While the transcriptomes of NF-Y- and PAX3-FOXO1-deficient RMS cells bear remarkable similarity to one another, we found that these two tran …
Ablation of Shank3 alleviates cardiac dysfunction in aging mice by promoting CaMKII activation and Parkin-mediated mitophagy.
Wang Y, Xu Y, Guo W, Fang Y, Hu L, Wang R, Zhao R, Guo D, Qi B, Ren G, Ren J, Li Y, Zhang M. Wang Y, et al. Redox Biol. 2022 Dec;58:102537. doi: 10.1016/j.redox.2022.102537. Epub 2022 Nov 18. Redox Biol. 2022. PMID: 36436456 Free PMC article.
Shank3 knock-down restored mitophagy, leading to increased mitochondrial membrane potential, decreased mitochondrial oxidative stress, and reduced apoptosis in senescent cardiomyocytes, whereas Shank3 overexpression mimicked D-gal-induced mitophagy inhibition and mitochondrial dy …
Shank3 knock-down restored mitophagy, leading to increased mitochondrial membrane potential, decreased mitochondrial oxidative stress, and r …
SALL4 is a CRL3(REN/KCTD11) substrate that drives Sonic Hedgehog-dependent medulloblastoma.
Lospinoso Severini L, Loricchio E, Navacci S, Basili I, Alfonsi R, Bernardi F, Moretti M, Conenna M, Cucinotta A, Coni S, Petroni M, De Smaele E, Giannini G, Maroder M, Canettieri G, Mastronuzzi A, Guardavaccaro D, Ayrault O, Infante P, Bufalieri F, Di Marcotullio L. Lospinoso Severini L, et al. Cell Death Differ. 2024 Feb;31(2):170-187. doi: 10.1038/s41418-023-01246-6. Epub 2023 Dec 7. Cell Death Differ. 2024. PMID: 38062245 Free PMC article.
Here, we show that the pro-oncogenic stemness regulator Spalt-like transcriptional factor 4 (SALL4) is re-expressed in mouse SHH-MB models, and its high levels correlate with worse overall survival in SHH-MB patients. Proteomic analysis revealed that SALL4 interacts with REN …
Here, we show that the pro-oncogenic stemness regulator Spalt-like transcriptional factor 4 (SALL4) is re-expressed in mouse SHH-MB models, …
Structural modifications of berberine and their binding effects towards polymorphic deoxyribonucleic acid structures: A review.
Fu L, Mou J, Deng Y, Ren X. Fu L, et al. Front Pharmacol. 2022 Aug 9;13:940282. doi: 10.3389/fphar.2022.940282. eCollection 2022. Front Pharmacol. 2022. PMID: 36016553 Free PMC article. Review.
Structural modification of BBR is an effective approach to improve its DNA binding activity and bioavailability in vivo. A large number of studies dedicated to improving the binding affinities of BBR towards different DNA structures have been carried out and achieve …
Structural modification of BBR is an effective approach to improve its DNA binding activity and bioavailability in vivo. A large numb …
TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.
Sun Y, Lin P, Zhou X, Ren Y, He Y, Liang J, Zhu Z, Xu X, Mao X. Sun Y, et al. Int J Biol Sci. 2023 May 29;19(9):2803-2816. doi: 10.7150/ijbs.81726. eCollection 2023. Int J Biol Sci. 2023. PMID: 37324936 Free PMC article.
Subsequently, we performed an affinity purification-coupled tandem mass spectrometry (MS/MS) and found the ubiquitin ligase TRIM26 in the PBX1 immunoprecipitates. Moreover, TRIM26 binds to and mediates PBX1 for K48-linked polyubiquitination and proteasomal degradation. ...
Subsequently, we performed an affinity purification-coupled tandem mass spectrometry (MS/MS) and found the ubiquitin ligase TRIM26 in the PB …
8,710 results