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Year Number of Results
1928 1
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1967 1
1969 4
1971 1
1972 2
1973 2
1974 2
1975 11
1976 17
1977 8
1978 10
1979 8
1980 10
1981 20
1982 21
1983 23
1984 27
1985 21
1986 36
1987 23
1988 31
1989 57
1990 53
1991 65
1992 72
1993 77
1994 94
1995 104
1996 119
1997 145
1998 171
1999 153
2000 198
2001 229
2002 287
2003 286
2004 352
2005 385
2006 455
2007 479
2008 556
2009 624
2010 676
2011 823
2012 952
2013 1108
2014 1235
2015 1330
2016 1419
2017 1538
2018 1756
2019 2032
2020 2341
2021 2653
2022 2828
2023 2734
2024 1174

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Did you mean bindingthe (14 results)?
N6-methyladenosine-dependent regulation of messenger RNA stability.
Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C. Wang X, et al. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27. Nature. 2014. PMID: 24284625 Free PMC article.
We further establish the role of YTHDF2 in RNA metabolism, showing that binding of YTHDF2 results in the localization of bound mRNA from the translatable pool to mRNA decay sites, such as processing bodies. ...Our results indicate that the dynamic m(6)A modification is rec …
We further establish the role of YTHDF2 in RNA metabolism, showing that binding of YTHDF2 results in the localization of bound mRNA f …
Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis.
Hsu PJ, Zhu Y, Ma H, Guo Y, Shi X, Liu Y, Qi M, Lu Z, Shi H, Wang J, Cheng Y, Luo G, Dai Q, Liu M, Guo X, Sha J, Shen B, He C. Hsu PJ, et al. Cell Res. 2017 Sep;27(9):1115-1127. doi: 10.1038/cr.2017.99. Epub 2017 Aug 15. Cell Res. 2017. PMID: 28809393 Free PMC article.
The biological function of YTHDC2, the final member of the YTH protein family, remains unknown. We report that YTHDC2 selectively binds m(6)A at its consensus motif. YTHDC2 enhances the translation efficiency of its targets and also decreases their mRNA abundance. ...The g …
The biological function of YTHDC2, the final member of the YTH protein family, remains unknown. We report that YTHDC2 selectively binds …
Thioredoxin1 Binding Metastasis-Associated Lung Adenocarcinoma Transcript 1 Attenuates Inflammation and Apoptosis after Intracerebral Hemorrhage.
Chen R, Xie Q, Xie L, Huang J, Hu L, Lu H, Shi P, He Q, Zhang Q, Gong C, Zhang S, Wang B, Yang G, Yang Q. Chen R, et al. Aging Dis. 2023 May 10. doi: 10.14336/AD.2023.0507. Online ahead of print. Aging Dis. 2023. PMID: 37196136
Post-transcriptional regulation and RNA-binding proteins (RBPs) play vital roles in the occurrence of secondary injury after intracerebral hemorrhage (ICH). ...Finally, RNA pull-down assays and in vitro experiments confirmed that Txn1 binds to metastasis-associated …
Post-transcriptional regulation and RNA-binding proteins (RBPs) play vital roles in the occurrence of secondary injury after intracer …
Fibrin and Fibrinolysis in Cancer.
Kwaan HC, Lindholm PF. Kwaan HC, et al. Semin Thromb Hemost. 2019 Jun;45(4):413-422. doi: 10.1055/s-0039-1688495. Epub 2019 Apr 30. Semin Thromb Hemost. 2019. PMID: 31041799 Review.
Plasmin activates latent growth factors, and breaks down extracellular matrix (ECM), while urokinase plasminogen activator (uPA) and the uPA receptor (uPAR) form complexes with vitronectin and integrins to promote tumor cells to adhere to the ECM. This complex also binds t …
Plasmin activates latent growth factors, and breaks down extracellular matrix (ECM), while urokinase plasminogen activator (uPA) and the uPA …
Promoter R-Loops Recruit U2AF1 to Modulate Its Phase Separation and RNA Splicing.
He X, Yuan J, Gao Z, Wang Y. He X, et al. J Am Chem Soc. 2023 Oct 4;145(39):21646-21660. doi: 10.1021/jacs.3c08204. Epub 2023 Sep 21. J Am Chem Soc. 2023. PMID: 37733759 Free PMC article.
By employing a bioinformatic approach based on overlap analysis of transcription factor chromatin immunoprecipitation sequencing (ChIP-seq) data sets, we found that many splicing factors, including U2AF1 whose recognition of the 3' splicing site is crucial for pre-mRNA splicing, …
By employing a bioinformatic approach based on overlap analysis of transcription factor chromatin immunoprecipitation sequencing (ChIP-seq) …
Factor XII Structure-Function Relationships.
Shamanaev A, Litvak M, Ivanov I, Srivastava P, Sun MF, Dickeson SK, Kumar S, He TZ, Gailani D. Shamanaev A, et al. Semin Thromb Hemost. 2023 Jun 5:10.1055/s-0043-1769509. doi: 10.1055/s-0043-1769509. Online ahead of print. Semin Thromb Hemost. 2023. PMID: 37276883
FXII activation and FXIIa activity are enhanced when the protein binds to a surface. Here, we review recent work on the structure and enzymology of FXII with an emphasis on how they relate to pathology. ...Intramolecular interactions involving the fibronectin type 2 and kr …
FXII activation and FXIIa activity are enhanced when the protein binds to a surface. Here, we review recent work on the structure and …
Discovery of myosin I and Pollard-san.
Oosawa F. Oosawa F. Biophys Rev. 2018 Dec;10(6):1481-1482. doi: 10.1007/s12551-018-0485-5. Epub 2018 Nov 16. Biophys Rev. 2018. PMID: 30446945 Free PMC article. Review.
I discuss the importance of the relationship among actin, myosin, and other actin-binding proteins, many of which were pioneered by Pollard-san ("-san" is a Japanese honorific suffix showing respect, politeness and friendship). ...I conclude that life is a dynamic accumula …
I discuss the importance of the relationship among actin, myosin, and other actin-binding proteins, many of which were pioneered by P …
ATP binds nucleic-acid-binding domains beyond RRM fold.
He Y, Kang J, Lim L, Song J. He Y, et al. Biochem Biophys Res Commun. 2020 Feb 19;522(4):826-831. doi: 10.1016/j.bbrc.2019.11.180. Epub 2019 Nov 30. Biochem Biophys Res Commun. 2020. PMID: 31791586
So can ATP also bind nucleic-acid-binding proteins without RRM fold? Here we characterized the interaction between ATP and SYNCRIP acidic domain (AcD), a non-canonical RNA-binding domain with no similarity to RRM fold in sequence and structure. ...Therefore, at conc …
So can ATP also bind nucleic-acid-binding proteins without RRM fold? Here we characterized the interaction between ATP and SYNCRIP ac …
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity.
Li H, Wang X, Wang Y, Li Y, Chen Y, Wong YT, He J, He ML. Li H, et al. Signal Transduct Target Ther. 2023 Sep 25;8(1):374. doi: 10.1038/s41392-023-01630-1. Signal Transduct Target Ther. 2023. PMID: 37743411 Free PMC article.
Infection by both coronavirus SARS-CoV-2 and enterovirus 71 (EV71 or EV-A71) can cause severe diseases such as neurological disorders and even death in children.(1-3) Here, we show evidence that the protease of SARS-CoV-2 (3CL(pro)) and EV71 (2A(pro)) upregulates the expression a …
Infection by both coronavirus SARS-CoV-2 and enterovirus 71 (EV71 or EV-A71) can cause severe diseases such as neurological disorders and ev …
Effect of Sex Hormone-Binding Globulin on Polycystic Ovary Syndrome: Mechanisms, Manifestations, Genetics, and Treatment.
Xing C, Zhang J, Zhao H, He B. Xing C, et al. Int J Womens Health. 2022 Feb 2;14:91-105. doi: 10.2147/IJWH.S344542. eCollection 2022. Int J Womens Health. 2022. PMID: 35140526 Free PMC article. Review.
Most women with PCOS have metabolic abnormalities. Sex hormone-binding globulin (SHBG), a transport carrier that binds estrogen and androgens and regulates their biological activity, is usually used as an indicator of hyperandrogenism in women with PCOS. ...
Most women with PCOS have metabolic abnormalities. Sex hormone-binding globulin (SHBG), a transport carrier that binds estroge …
26,685 results
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