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Year Number of Results
1975 1
1981 1
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1986 4
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1988 11
1989 12
1990 15
1991 26
1992 31
1993 44
1994 43
1995 53
1996 74
1997 72
1998 96
1999 99
2000 99
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2003 231
2004 269
2005 305
2006 341
2007 385
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2011 633
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2018 1414
2019 1548
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2021 2002
2022 2075
2023 1886
2024 824

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20,292 results

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Showing results for binding, gao
Search for binbin, gao instead (1 results)
A gut-derived hormone regulates cholesterol metabolism.
Hu X, Chen F, Jia L, Long A, Peng Y, Li X, Huang J, Wei X, Fang X, Gao Z, Zhang M, Liu X, Chen YG, Wang Y, Zhang H, Wang Y. Hu X, et al. Cell. 2024 Mar 28;187(7):1685-1700.e18. doi: 10.1016/j.cell.2024.02.024. Epub 2024 Mar 18. Cell. 2024. PMID: 38503280
It is secreted from the intestine in response to cholesterol absorption and binds to GPR146, an orphan G-protein-coupled receptor, exerting antagonistic downstream effects by inhibiting PKA signaling and thereby suppressing SREBP2-controlled cholesterol synthesis in the li …
It is secreted from the intestine in response to cholesterol absorption and binds to GPR146, an orphan G-protein-coupled receptor, ex …
Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2.
Han P, Li L, Liu S, Wang Q, Zhang D, Xu Z, Han P, Li X, Peng Q, Su C, Huang B, Li D, Zhang R, Tian M, Fu L, Gao Y, Zhao X, Liu K, Qi J, Gao GF, Wang P. Han P, et al. Cell. 2022 Feb 17;185(4):630-640.e10. doi: 10.1016/j.cell.2022.01.001. Epub 2022 Jan 6. Cell. 2022. PMID: 35093192 Free PMC article.
A recent VOC, omicron (B.1.1.529), which obtains a large number of mutations in the receptor-binding domain (RBD) of the spike protein, has risen to intense scientific and public attention. ...We found that, unlike alpha, beta, and gamma, omicron RBD binds to hACE2 …
A recent VOC, omicron (B.1.1.529), which obtains a large number of mutations in the receptor-binding domain (RBD) of the spike protei …
Structural basis of membrane skeleton organization in red blood cells.
Li N, Chen S, Xu K, He MT, Dong MQ, Zhang QC, Gao N. Li N, et al. Cell. 2023 Apr 27;186(9):1912-1929.e18. doi: 10.1016/j.cell.2023.03.017. Epub 2023 Apr 11. Cell. 2023. PMID: 37044097
Here, we report the cryo-EM structures of the native spectrin-actin junctional complex (from porcine erythrocytes), which is a specialized short F-actin acting as the central organizational unit of the membrane skeleton. While an alpha-/beta-adducin hetero-tetramer binds t …
Here, we report the cryo-EM structures of the native spectrin-actin junctional complex (from porcine erythrocytes), which is a specialized s …
Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants.
Zhao Z, Xie Y, Bai B, Luo C, Zhou J, Li W, Meng Y, Li L, Li D, Li X, Li X, Wang X, Sun J, Xu Z, Sun Y, Zhang W, Fan Z, Zhao X, Wu L, Ma J, Li OY, Shang G, Chai Y, Liu K, Wang P, Gao GF, Qi J. Zhao Z, et al. Nat Commun. 2023 Jul 21;14(1):4405. doi: 10.1038/s41467-023-39942-z. Nat Commun. 2023. PMID: 37479708 Free PMC article.
Additionally, BA.2.75 is significantly increasing in some countries. Exploring their receptor binding and interspecies transmission risk is urgently needed. Herein, we examine the binding capacities of human and other 28 animal ACE2 orthologs covering nine orders to …
Additionally, BA.2.75 is significantly increasing in some countries. Exploring their receptor binding and interspecies transmission r …
SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology.
Huang J, Wu C, Kloeber JA, Gao H, Gao M, Zhu Q, Chang Y, Zhao F, Guo G, Luo K, Dai H, Liu S, Huang Q, Kim W, Zhou Q, Zhu S, Wu Z, Tu X, Yin P, Deng M, Wang L, Yuan J, Lou Z. Huang J, et al. Mol Cell. 2023 Apr 6;83(7):1043-1060.e10. doi: 10.1016/j.molcel.2023.02.004. Epub 2023 Feb 27. Mol Cell. 2023. PMID: 36854302 Free PMC article.
Here, we report that SLFN5 is a critical factor for 53BP1 topological arrangement at DSBs. Using super-resolution imaging, we find that SLFN5 binds to 53BP1 chromatin domains to assemble a higher-order microdomain architecture by driving damaged chromatin dynamics at both …
Here, we report that SLFN5 is a critical factor for 53BP1 topological arrangement at DSBs. Using super-resolution imaging, we find that SLFN …
IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.
Jiang Z, Wei F, Zhang Y, Wang T, Gao W, Yu S, Sun H, Pu J, Sun Y, Wang M, Tong Q, Gao C, Chang KC, Liu J. Jiang Z, et al. Nat Microbiol. 2021 Jul;6(7):932-945. doi: 10.1038/s41564-021-00907-x. Epub 2021 May 13. Nat Microbiol. 2021. PMID: 33986530
IFI16 positively upregulates RIG-I transcription through direct binding to and recruitment of RNA polymerase II to the RIG-I promoter. IFI16 also binds to influenza viral RNA via its HINa domain and to RIG-I protein with its PYRIN domain, thus promoting IAV-induced …
IFI16 positively upregulates RIG-I transcription through direct binding to and recruitment of RNA polymerase II to the RIG-I promoter …
Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity.
Zhao C, Ma Y, Zhang M, Gao X, Liang W, Qin Y, Fu Y, Jia M, Song H, Gao C, Zhao W. Zhao C, et al. Immunity. 2023 Nov 14;56(11):2508-2522.e6. doi: 10.1016/j.immuni.2023.09.012. Epub 2023 Oct 16. Immunity. 2023. PMID: 37848037
Cyclic guanosine monophosphate (GMP)-AMP (cGAMP) synthase (cGAS) is a universal double-stranded DNA (dsDNA) sensor that recognizes foreign and self-DNA in the cytoplasm and initiates innate immune responses and has been implicated in various infectious and non-infectious contexts …
Cyclic guanosine monophosphate (GMP)-AMP (cGAMP) synthase (cGAS) is a universal double-stranded DNA (dsDNA) sensor that recognizes foreign a …
New insights into the non-enzymatic function of HDAC6.
Zhu Y, Feng M, Wang B, Zheng Y, Jiang D, Zhao L, Mamun MAA, Kang H, Nie H, Zhang X, Guo N, Qin S, Wang N, Liu H, Gao Y. Zhu Y, et al. Biomed Pharmacother. 2023 May;161:114438. doi: 10.1016/j.biopha.2023.114438. Epub 2023 Mar 9. Biomed Pharmacother. 2023. PMID: 37002569 Free article. Review.
Histone deacetylase 6 (HDAC6) is a class IIb histone deacetylase that contains two catalytic domains and a zinc-finger ubiquitin binding domain (ZnF-UBP) domain. The deacetylation function of HDAC6 has been extensively studied with common substrates such as alpha-tubulin, …
Histone deacetylase 6 (HDAC6) is a class IIb histone deacetylase that contains two catalytic domains and a zinc-finger ubiquitin binding …
Linker Histone in Diseases.
Ye X, Feng C, Gao T, Mu G, Zhu W, Yang Y. Ye X, et al. Int J Biol Sci. 2017 Jul 18;13(8):1008-1018. doi: 10.7150/ijbs.19891. eCollection 2017. Int J Biol Sci. 2017. PMID: 28924382 Free PMC article. Review.
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. ...
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in th …
Influence of a family 29 carbohydrate binding module on the activity of galactose oxidase from Fusarium graminearum.
Mollerup F, Parikka K, Vuong TV, Tenkanen M, Master E. Mollerup F, et al. Biochim Biophys Acta. 2016 Feb;1860(2):354-62. doi: 10.1016/j.bbagen.2015.10.023. Epub 2015 Oct 27. Biochim Biophys Acta. 2016. PMID: 26518347
Here we investigate the impact of a family 29 glucomannan binding module on the activity and binding of GaO towards various polysaccharides. ...The fusion of CBM29 also induced oligomerization of GaO-CBM29. MAJOR CONCLUSIONS: Similar to impacts of cell …
Here we investigate the impact of a family 29 glucomannan binding module on the activity and binding of GaO towards var …
20,292 results
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