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1983 1
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2002 3
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2004 1
2005 2
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2009 8
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136 results

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Page 1
Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue.
Dion-Albert L, Cadoret A, Doney E, Kaufmann FN, Dudek KA, Daigle B, Parise LF, Cathomas F, Samba N, Hudson N, Lebel M; Signature Consortium; Campbell M, Turecki G, Mechawar N, Menard C. Dion-Albert L, et al. Nat Commun. 2022 Jan 10;13(1):164. doi: 10.1038/s41467-021-27604-x. Nat Commun. 2022. PMID: 35013188 Free PMC article.
Here, we report that chronic social and subchronic variable stress promotes blood-brain barrier (BBB) alterations in mood-related brain regions of female mice. ...
Here, we report that chronic social and subchronic variable stress promotes blood-brain barrier (BBB) alterations in mood-related bra …
Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization.
Nora EP, Goloborodko A, Valton AL, Gibcus JH, Uebersohn A, Abdennur N, Dekker J, Mirny LA, Bruneau BG. Nora EP, et al. Cell. 2017 May 18;169(5):930-944.e22. doi: 10.1016/j.cell.2017.05.004. Cell. 2017. PMID: 28525758 Free PMC article.
Furthermore, our data support that CTCF mediates transcriptional insulator function through enhancer blocking but not as a direct barrier to heterochromatin spreading. Beyond defining the functions of CTCF in chromosome folding, these results provide new fundamental insigh …
Furthermore, our data support that CTCF mediates transcriptional insulator function through enhancer blocking but not as a direct barrier …
Anticancer drug delivery by focused ultrasound-mediated blood-brain/tumor barrier disruption for glioma therapy: From benchside to bedside.
Bérard C, Truillet C, Larrat B, Dhermain F, Estève MA, Correard F, Novell A. Bérard C, et al. Pharmacol Ther. 2023 Oct;250:108518. doi: 10.1016/j.pharmthera.2023.108518. Epub 2023 Aug 22. Pharmacol Ther. 2023. PMID: 37619931 Review.
Brain tumors present multiple obstacles that make therapeutic innovation complex, mainly due to the presence of blood-tumor and blood-brain barriers (BTB and BBB, respectively) which prevent penetration of anticancer agents into the brain parenchyma. ...
Brain tumors present multiple obstacles that make therapeutic innovation complex, mainly due to the presence of blood-tumor and blood-brain …
A brain-specific angiogenic mechanism enabled by tip cell specialization.
Schevenels G, Cabochette P, America M, Vandenborne A, De Grande L, Guenther S, He L, Dieu M, Christou B, Vermeersch M, Germano RFV, Perez-Morga D, Renard P, Martin M, Vanlandewijck M, Betsholtz C, Vanhollebeke B. Schevenels G, et al. Nature. 2024 Apr;628(8009):863-871. doi: 10.1038/s41586-024-07283-6. Epub 2024 Apr 3. Nature. 2024. PMID: 38570687 Free PMC article.
Here, opposing this model, we reveal a molecular mechanism for brain-specific angiogenesis that operates under the control of Wnt7a/b ligands-well-known blood-brain barrier maturation signals(3-5). The control mechanism relies on Wnt7a/b-dependent expression of Mmp25, whic …
Here, opposing this model, we reveal a molecular mechanism for brain-specific angiogenesis that operates under the control of Wnt7a/b ligand …
36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.
Bateman RM, Sharpe MD, Jagger JE, Ellis CG, Solé-Violán J, López-Rodríguez M, Herrera-Ramos E, Ruíz-Hernández J, Borderías L, Horcajada J, González-Quevedo N, Rajas O, Briones M, Rodríguez de Castro F, Rodríguez Gallego C, Esen F, Orhun G, Ergin Ozcan P, Senturk E, Ugur Yilmaz C, Orhan N, Arican N, Kaya M, Kucukerden M, Giris M, Akcan U, Bilgic Gazioglu S, Tuzun E, Riff R, Naamani O, Douvdevani A, Takegawa R, Yoshida H, Hirose T, Yamamoto N, Hagiya H, Ojima M, Akeda Y, Tasaki O, Tomono K, Shimazu T, Ono S, Kubo T, Suda S, Ueno T, Ikeda T, Hirose T, Ogura H, Takahashi H, Ojima M, Kang J, Nakamura Y, Kojima T, Shimazu T, Ikeda T, Suda S, Izutani Y, Ueno T, Ono S, Taniguchi T, O M, Dinter C, Lotz J, Eilers B, Wissmann C, Lott R, Meili MM, Schuetz PS, Hawa H, Sharshir M, Aburageila M, Salahuddin N, Chantziara V, Georgiou S, Tsimogianni A, Alexandropoulos P, Vassi A, Lagiou F, Valta M, Micha G, Chinou E, Michaloudis G, Kodaira A, Ikeda T, Ono S, Ueno T, Suda S, Izutani Y, Imaizumi H, De la Torre-Prados MV, Garcia-De la Torre A, Enguix-Armada A, Puerto-Morlan A, Perez-Valero V, Garcia-Alcantara A, Bolton N, Dudziak J, Bonney S, Tridente A, Nee P, Nicolaes G, Wiewel M, Schultz M, Wildhag… See abstract for full author list ➔ Bateman RM, et al. Crit Care. 2016 Apr 20;20(Suppl 2):94. doi: 10.1186/s13054-016-1208-6. Crit Care. 2016. PMID: 27885969 Free PMC article.
Schneider P227 - Long-term outcome and health-related quality of life in patients discharged from the intensive care unit with a tracheostomy and with or without prolonged mechanical ventilation S. De Smet, S. De Raedt, E. Derom, P Depuydt, S. Oeyen, D. Benoit, J. Decruyen …
Schneider P227 - Long-term outcome and health-related quality of life in patients discharged from the intensive care unit with a tracheostom …
Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions.
Doney E, Dion-Albert L, Coulombe-Rozon F, Osborne N, Bernatchez R, Paton SEJ, Kaufmann FN, Agomma RO, Solano JL, Gaumond R, Dudek KA, Szyszkowicz JK; Cecile Lepage on behalf of Signature Consortium; Lebel M, Doyen A, Durand A, Lavoie-Cardinal F, Audet MC, Menard C. Doney E, et al. Biol Psychiatry Glob Open Sci. 2023 May 8;4(1):213-228. doi: 10.1016/j.bpsgos.2023.04.007. eCollection 2024 Jan. Biol Psychiatry Glob Open Sci. 2023. PMID: 38306213 Free PMC article.
Dysfunction in the microbiota-gut-brain axis has been implicated in MDD pathogenesis. Exposure to chronic stress disrupts blood-brain barrier integrity; still, little is known about intestinal barrier function in these conditions, particularly for the small intestin …
Dysfunction in the microbiota-gut-brain axis has been implicated in MDD pathogenesis. Exposure to chronic stress disrupts blood-brain bar …
Computational studies of the gramicidin channel.
Roux B. Roux B. Acc Chem Res. 2002 Jun;35(6):366-75. doi: 10.1021/ar010028v. Acc Chem Res. 2002. PMID: 12069621 Review.
Ion channels are highly specific membrane-spanning protein structures which serve to facilitate the passage of selected ions across the lipid barrier. In the past decade, molecular dynamics simulations based on atomic models and realistic microscopic interactions with expl …
Ion channels are highly specific membrane-spanning protein structures which serve to facilitate the passage of selected ions across the lipi …
Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review.
Pansieri J, Gerstenmayer M, Lux F, Mériaux S, Tillement O, Forge V, Larrat B, Marquette C. Pansieri J, et al. Nanomaterials (Basel). 2018 Sep 18;8(9):740. doi: 10.3390/nano8090740. Nanomaterials (Basel). 2018. PMID: 30231587 Free PMC article. Review.
Here, we report that AGuIX nanoparticles grafted with the Pittsburgh compound B can actively target amyloid aggregates in the brain, beyond the blood-brain barrier, and remain the first step in observing amyloid plaques in a mouse model of Alzheimer's disease....
Here, we report that AGuIX nanoparticles grafted with the Pittsburgh compound B can actively target amyloid aggregates in the brain, beyond …
Reproductive late effects after hematopoietic stem cell transplant in pediatric, adolescent, and young adult cancer survivors.
Appiah LC, Moravek M, Hoefgen H, Rotz S, Childress K, Samis J, Benoit J, Rodriguez-Wallberg K, Anazodo A. Appiah LC, et al. Pediatr Blood Cancer. 2023 Sep;70 Suppl 5:e30551. doi: 10.1002/pbc.30551. Epub 2023 Jul 20. Pediatr Blood Cancer. 2023. PMID: 37470746 Review.
Patient barriers include a reluctance to report symptoms and lack of awareness of treatment options. System barriers include inefficient implementation of screening tools and poor dissemination of guidelines to providers who serve as the medical home for survivors. …
Patient barriers include a reluctance to report symptoms and lack of awareness of treatment options. System barriers include i …
136 results