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Page 1
Five-Year Outcomes With Pembrolizumab Versus Chemotherapy as First-Line Therapy in Patients With Non-Small-Cell Lung Cancer and Programmed Death Ligand-1 Tumor Proportion Score ≥ 1% in the KEYNOTE-042 Study.
de Castro G Jr, Kudaba I, Wu YL, Lopes G, Kowalski DM, Turna HZ, Caglevic C, Zhang L, Karaszewska B, Laktionov KK, Srimuninnimit V, Bondarenko I, Kubota K, Mukherjee R, Lin J, Souza F, Mok TSK, Cho BC. de Castro G Jr, et al. J Clin Oncol. 2023 Apr 10;41(11):1986-1991. doi: 10.1200/JCO.21.02885. Epub 2022 Oct 28. J Clin Oncol. 2023. PMID: 36306479 Free PMC article. Clinical Trial.
Primary end points were overall survival (OS) in PD-L1 TPS 50%, 20%, and 1% groups. Patients who completed 35 cycles of pembrolizumab with stable disease could begin second-course pembrolizumab upon progression. ...
Primary end points were overall survival (OS) in PD-L1 TPS 50%, 20%, and 1% groups. Patients who completed 35 cycles of pembrolizumab with …
Patient-Reported Outcomes in KEYNOTE-564: Adjuvant Pembrolizumab Versus Placebo for Renal Cell Carcinoma.
Choueiri TK, Tomczak P, Park SH, Venugopal B, Symeonides S, Hajek J, Ferguson T, Chang YH, Lee JL, Haas N, Sawrycki P, Sarwar N, Gross-Goupil M, Thiery-Vuillemin A, Mahave M, Kimura G, Perini RF, Saretsky TL, Bhattacharya R, Xu L, Powles T. Choueiri TK, et al. Oncologist. 2024 Feb 2;29(2):142-150. doi: 10.1093/oncolo/oyad231. Oncologist. 2024. PMID: 37589219 Free PMC article. Clinical Trial.
RESULTS: No clinically meaningful difference in least squares mean scores for pembrolizumab versus placebo were observed at week 52 for EORTC QLQ-C30 GHS/QoL (-2.5; 95% CI -5.2 to 0.1), EORTC QLQ-C30 physical functioning (-0.87; 95% CI -2.7 to 1.0), and FKSI-DRS (-0.7; 95% CI -1. …
RESULTS: No clinically meaningful difference in least squares mean scores for pembrolizumab versus placebo were observed at week 52 for EORT …
Thermal adaptation of heat shock proteins.
Muga A, Moro F. Muga A, et al. Curr Protein Pept Sci. 2008 Dec;9(6):552-66. doi: 10.2174/138920308786733903. Curr Protein Pept Sci. 2008. PMID: 19075746 Review.
Apart from assisting in the efficient folding of newly synthesized proteins they maintain pre-existing proteins in a stable conformation, preventing their aggregation, under stress conditions. ...
Apart from assisting in the efficient folding of newly synthesized proteins they maintain pre-existing proteins in a stable conformat …
Ag5 nanoclusters with dual catalytic antiradical activities.
Arias IR, Buceta D, Barone G, Giménez-López MC, Lozano H, Lazzari M, Arturo López-Quintela M. Arias IR, et al. J Colloid Interface Sci. 2022 Dec 15;628(Pt A):437-447. doi: 10.1016/j.jcis.2022.07.133. Epub 2022 Jul 25. J Colloid Interface Sci. 2022. PMID: 35932680 Free article.
Using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical as a model system, we observed a fast radical reduction to DPPH anions using only [Ag(5)] 3 to 4 orders of magnitude less than [DPPH]. Moreover, nanoclusters remain stable at the end of the reaction, and can deactivate aga …
Using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical as a model system, we observed a fast radical reduction to DPPH anions using only [Ag(5)] …
Sleep accelerates re-stabilization of human declarative memories.
Moyano MD, Diekelmann S, Pedreira ME, Forcato C. Moyano MD, et al. Neurobiol Learn Mem. 2019 Jul;162:1-8. doi: 10.1016/j.nlm.2019.04.012. Epub 2019 Apr 25. Neurobiol Learn Mem. 2019. PMID: 31029768
We found that the 90 min sleep group showed an intact RIF effect similar to the 10 h wake group, reflecting stable List 1 memory after 90 min of sleep and after 10 h of wakefulness. ...
We found that the 90 min sleep group showed an intact RIF effect similar to the 10 h wake group, reflecting stable List 1 memory afte …
The growing role of gene methylation on endocrine function.
García-Carpizo V, Ruiz-Llorente L, Fraga M, Aranda A. García-Carpizo V, et al. J Mol Endocrinol. 2011 Sep 19;47(2):R75-89. doi: 10.1530/JME-11-0059. Print 2011 Oct. J Mol Endocrinol. 2011. PMID: 21803863 Review.
DNA methylation is the best studied epigenetic factor, playing a key role in producing stable changes in gene expression, thus defining cell identity and function and adapting cells to environmental changes. ...
DNA methylation is the best studied epigenetic factor, playing a key role in producing stable changes in gene expression, thus defini …
Strong carbon - noble gas covalent bond and fluxionality in hypercoordinate compounds.
Vásquez-Espinal A, Pino-Rios R. Vásquez-Espinal A, et al. Phys Chem Chem Phys. 2023 Oct 18;25(40):27468-27474. doi: 10.1039/d3cp03576j. Phys Chem Chem Phys. 2023. PMID: 37800185
Thermodynamic, kinetic, and chemical bonding analysis at the coupled cluster level has been carried out for a series of hypercoordinated carbon compounds with formula CH(4)Ng(2+) (Ng = He-Rn). Results show that these compounds could be stable at room temperature and Born-O …
Thermodynamic, kinetic, and chemical bonding analysis at the coupled cluster level has been carried out for a series of hypercoordinated car …
The Use of Flavylium Salts as Dynamic Inhibitor Moieties for Human Cb5R.
Martínez-Costa OH, Rodrigues-Miranda L, Clemente SM, Parola AJ, Basilio N, Samhan-Arias AK. Martínez-Costa OH, et al. Molecules. 2022 Dec 23;28(1):123. doi: 10.3390/molecules28010123. Molecules. 2022. PMID: 36615312 Free PMC article.
Although usually represented by the flavylium cation form, these species are only stable at rather acidic pH values (pH 1). At higher pH values, the flavylium cation is involved in a dynamic reaction network comprising different neutral species with the potential ability t …
Although usually represented by the flavylium cation form, these species are only stable at rather acidic pH values (pH 1). At higher …
Experimental and Simulation Studies on Hematite Interaction with Na-Metasilicate Pentahydrate.
Quezada GR, Toro N, Krishna RS, Mishra S, Robles P, Salazar I, Mathe E, Jeldres RI. Quezada GR, et al. Molecules. 2023 Apr 21;28(8):3629. doi: 10.3390/molecules28083629. Molecules. 2023. PMID: 37110863 Free PMC article.
To understand the behavior observed experimentally, computational simulation has been used by means of quantum calculations to represent the metasilicate molecule and the molecular dynamics to study the adsorption of metasilicate on the hematite surface. It has been possible to o …
To understand the behavior observed experimentally, computational simulation has been used by means of quantum calculations to represent the …
59 results