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Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study.
Jones D, Boudes PF, Swain MG, Bowlus CL, Galambos MR, Bacon BR, Doerffel Y, Gitlin N, Gordon SC, Odin JA, Sheridan D, Wörns MA, Clark V, Corless L, Hartmann H, Jonas ME, Kremer AE, Mells GF, Buggisch P, Freilich BL, Levy C, Vierling JM, Bernstein DE, Hartleb M, Janczewska E, Rochling F, Shah H, Shiffman ML, Smith JH, Choi YJ, Steinberg A, Varga M, Chera H, Martin R, McWherter CA, Hirschfield GM. Jones D, et al. Lancet Gastroenterol Hepatol. 2017 Oct;2(10):716-726. doi: 10.1016/S2468-1253(17)30246-7. Epub 2017 Aug 14. Lancet Gastroenterol Hepatol. 2017. PMID: 28818518 Clinical Trial.
During recruitment, three patients treated with seladelpar developed fully reversible, asymptomatic grade 3 alanine aminotransferase increases (one on 50 mg, two on 200 mg), ranging from just over five to 20 times the ULN; as a result, the study was terminated after 41 pat …
During recruitment, three patients treated with seladelpar developed fully reversible, asymptomatic grade 3 alanine aminotransferase …
Surgical management of posterior petrous meningiomas.
Nowak A, Dziedzic T, Marchel A. Nowak A, et al. Neurol Neurochir Pol. 2013 Sep-Oct;47(5):456-66. doi: 10.5114/ninp.2013.38225. Neurol Neurochir Pol. 2013. PMID: 24166567
The tumour was found to be attached to the premeatal dura in 46%, the inframeatal dura in 29% and the postmeatal dura in 25% of cases. Tumour resection was categorized as grade I in 16 patients, grade II in 29 patients, grade III in 1 patient and grade …
The tumour was found to be attached to the premeatal dura in 46%, the inframeatal dura in 29% and the postmeatal dura in 25% of cases. Tumou …
Randomized Study of Maintenance Pemetrexed Versus Observation for Treatment of Malignant Pleural Mesothelioma: CALGB 30901.
Dudek AZ, Wang X, Gu L, Duong S, Stinchcombe TE, Kratzke R, Borghaei H, Vokes EE, Kindler HL. Dudek AZ, et al. Clin Lung Cancer. 2020 Nov;21(6):553-561.e1. doi: 10.1016/j.cllc.2020.06.025. Epub 2020 Jul 3. Clin Lung Cancer. 2020. PMID: 32727707 Free PMC article. Clinical Trial.
The median overall survival (OS) was 11.8 months (95% CI, 9.3-28.7 months) for observation, and 16.3 months (95% CI, 10.5-26.0 months) for pemetrexed (HR, 0.86; 95% CI, 0.44-1.71; P = .6737). Grade 3 or 4 toxicities on the pemetrexed arm included anemia (8%), lymphopenia ( …
The median overall survival (OS) was 11.8 months (95% CI, 9.3-28.7 months) for observation, and 16.3 months (95% CI, 10.5-26.0 months) for p …
Standardized flexible ureteroscopic technique to improve stone-free rates.
Miernik A, Wilhelm K, Ardelt PU, Adams F, Kuehhas FE, Schoenthaler M. Miernik A, et al. Urology. 2012 Dec;80(6):1198-202. doi: 10.1016/j.urology.2012.08.042. Urology. 2012. PMID: 23206763
The use of an access sheath was required in 71% of the patients and the postoperative use of a double-J stent in 57% of patients. Complications (Clavien grade II and III) developed in 9.1% of patients (including 7 with minimal perforation that required ureteral stenting fo …
The use of an access sheath was required in 71% of the patients and the postoperative use of a double-J stent in 57% of patients. Complicati …
Machine learning approaches to analyze histological images of tissues from radical prostatectomies.
Gertych A, Ing N, Ma Z, Fuchs TJ, Salman S, Mohanty S, Bhele S, Velásquez-Vacca A, Amin MB, Knudsen BS. Gertych A, et al. Comput Med Imaging Graph. 2015 Dec;46 Pt 2(Pt 2):197-208. doi: 10.1016/j.compmedimag.2015.08.002. Epub 2015 Aug 20. Comput Med Imaging Graph. 2015. PMID: 26362074 Free PMC article.
Two pathologists manually annotated 210 images of low- and high-grade tumors from slides that were selected from 20 radical prostatectomies and digitized at high-resolution. ...Our pixel-based classification does not rely on the detection of lumens, which is prone to error …
Two pathologists manually annotated 210 images of low- and high-grade tumors from slides that were selected from 20 radical prostatec …
Phenomenon of declining blood pressure in elderly--high systolic levels are undervalued with Korotkoff method.
Siennicki-Lantz A, Elmståhl S. Siennicki-Lantz A, et al. BMC Geriatr. 2011 Oct 3;11:57. doi: 10.1186/1471-2318-11-57. BMC Geriatr. 2011. PMID: 21967408 Free PMC article.
Increasing SG-BP was also predicted by high B-glucose and low ABI at age 68, and correlated with carotid stenosis and low ABI age 81, and the grade of ABI decrease over 13 years. CONCLUSION: In contrast to K-BP, values of SG-BP in octogenarians strongly correlated with Amb …
Increasing SG-BP was also predicted by high B-glucose and low ABI at age 68, and correlated with carotid stenosis and low ABI age 81, and th …