Anti-Inflammatory Effects of 5alpha,8alpha-Epidioxycholest-6-en-3beta-ol, a Steroidal Endoperoxide Isolated from Aplysia depilans, Based on Bioguided Fractionation and NMR Analysis.
Pereira RB, Pereira DM, Jiménez C, Rodríguez J, Nieto RM, Videira RA, Silva O, Andrade PB, Valentão P.
Pereira RB, et al.
Mar Drugs. 2019 Jun 3;17(6):330. doi: 10.3390/md17060330.
Mar Drugs. 2019.
PMID: 31163615
Free PMC article.
Moreover, EnP(5,8) also inhibited the LPS-induced expression of cyclooxygenase-2 (COX-2), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) at the mRNA and protein levels. Mild selective inhibition of COX-2 enzyme activity was also evidenced. Our fin …
Moreover, EnP(5,8) also inhibited the LPS-induced expression of cyclooxygenase-2 (COX-2), interleukin 6 (IL-6), and tumor necrosis fa …