Abstract
Experimental models of stomatitis developing in response to an isolated (radiation) and combined (radiation and chemical) exposure of experimental animals, were created. The severity of radiation-induced stomatitis was determined by the dose of radiation exposure. Additional exposure to a chemical factor (cyclophosphamide) augmented the destructive effect of ionizing radiation on the buccal mucosa of rats.
MeSH terms
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Animals
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Animals, Outbred Strains
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Antineoplastic Agents, Alkylating / toxicity*
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Appetite / drug effects
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Appetite / radiation effects
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Chemoradiotherapy / adverse effects
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Cyclophosphamide / toxicity*
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Disease Models, Animal
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Motor Activity / drug effects
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Motor Activity / radiation effects
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Mouth Mucosa / drug effects
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Mouth Mucosa / pathology
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Mouth Mucosa / radiation effects*
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Radiation Injuries, Experimental / etiology
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Radiation Injuries, Experimental / pathology
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Radiation Injuries, Experimental / physiopathology*
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Rats
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Stomatitis / etiology
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Stomatitis / pathology
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Stomatitis / physiopathology*
Substances
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Antineoplastic Agents, Alkylating
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Cyclophosphamide