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Page 1
Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.
Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C. Li X, et al. J Am Chem Soc. 2018 May 30;140(21):6518-6521. doi: 10.1021/jacs.8b02100. Epub 2018 May 18. J Am Chem Soc. 2018. PMID: 29762030 Free PMC article.
By the use of a fully human naive antigen-binding fragment (F(ab)) library, a high-affinity antibody was identified that bound to the extended conformation of a PKS module, as verified by X-ray crystallography and tandem size-exclusion chromatography-small-angle X-ray scat …
By the use of a fully human naive antigen-binding fragment (F(ab)) library, a high-affinity antibody was identified that bound to the extend …
[Iris microhaemangiomas: presentation of a case].
Méndez-Cepeda P, Viso E, Sevillano C, Lugo E. Méndez-Cepeda P, et al. Arch Soc Esp Oftalmol. 2014 Feb;89(2):74-6. doi: 10.1016/j.oftal.2012.07.024. Epub 2012 Oct 6. Arch Soc Esp Oftalmol. 2014. PMID: 24269403 Spanish.
Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase.
Li X, Sevillano N, La Greca F, Hsu J, Mathews II, Matsui T, Craik CS, Khosla C. Li X, et al. Biochemistry. 2018 Oct 30;57(43):6201-6208. doi: 10.1021/acs.biochem.8b00886. Epub 2018 Oct 17. Biochemistry. 2018. PMID: 30289692 Free PMC article.
F(ab) binding had minimal effects on the structural integrity of the TE. In turn, these insights were used to interrogate via small-angle X-ray scattering the solution-phase conformation of 3A6 complexed to a catalytically competent PKS module and bimodule. ...
F(ab) binding had minimal effects on the structural integrity of the TE. In turn, these insights were used to interrogate via small-angle …
Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction.
Cogan DP, Li X, Sevillano N, Mathews II, Matsui T, Craik CS, Khosla C. Cogan DP, et al. J Am Chem Soc. 2020 Sep 2;142(35):14933-14939. doi: 10.1021/jacs.0c05133. Epub 2020 Aug 18. J Am Chem Soc. 2020. PMID: 32786753 Free PMC article.
A hybrid PKS module harboring KR1 was engineered, whose individual catalytic domains have been crystallographically characterized at high resolution. Size exclusion chromatography coupled to small-angle X-ray scattering (SEC-SAXS) of this hybrid module bound to 1D10 provid …
A hybrid PKS module harboring KR1 was engineered, whose individual catalytic domains have been crystallographically characterized at high re …
Dosimetric analysis of rectal filling on rectal doses during vaginal cuff brachytherapy.
Sabater S, Arenas M, Berenguer R, Machin-Hamalainen S, Andres I, Sevillano MM, Jimenez-Jimenez E, Martos A, Lopez-Honrubia V, Fernandez-Lopez J. Sabater S, et al. Brachytherapy. 2015 Jul-Aug;14(4):458-63. doi: 10.1016/j.brachy.2015.02.391. Epub 2015 Apr 18. Brachytherapy. 2015. PMID: 25900391
Multiple linear regression models found that rectal volume, cylinder angle position, and cylinder diameter variables correlated significantly with the different DVH parameters analyzed. ...
Multiple linear regression models found that rectal volume, cylinder angle position, and cylinder diameter variables correlated signi …
Measurement and correction of leaf open times in helical tomotherapy.
Sevillano D, Minguez C, Sanchez A, Sanchez-Reyes A. Sevillano D, et al. Med Phys. 2012 Nov;39(11):6972-80. doi: 10.1118/1.4762565. Med Phys. 2012. PMID: 23127091
Corrected sinograms improved error distribution, with standard deviations of over 3 ms and increased percentages of points passing 3% in the fluence per angle analysis, especially in treatments with a short mean LOT and those that were more subject to latency effects. ...
Corrected sinograms improved error distribution, with standard deviations of over 3 ms and increased percentages of points passing 3% in the …