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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1866 1
1867 1
1874 2
1881 1
1895 1
1916 1
1929 1
1931 2
1939 1
1942 1
1945 3
1947 1
1948 14
1949 11
1950 8
1951 4
1952 11
1953 7
1954 5
1955 5
1956 6
1957 11
1958 17
1959 11
1960 11
1961 11
1962 36
1963 37
1964 49
1965 57
1966 38
1967 47
1968 34
1969 51
1970 78
1971 93
1972 111
1973 116
1974 116
1975 172
1976 186
1977 194
1978 195
1979 242
1980 275
1981 254
1982 253
1983 296
1984 328
1985 370
1986 419
1987 461
1988 555
1989 589
1990 581
1991 592
1992 676
1993 734
1994 792
1995 913
1996 1055
1997 1055
1998 1101
1999 1326
2000 1525
2001 1751
2002 1919
2003 2112
2004 2282
2005 2656
2006 2881
2007 3269
2008 5044
2009 5988
2010 6470
2011 6923
2012 7059
2013 6174
2014 6179
2015 6603
2016 6243
2017 6936
2018 7651
2019 8604
2020 10523
2021 11913
2022 11753
2023 11094
2024 4062

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146,798 results

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Page 1
HO-1 overexpression and underexpression: Clinical implications.
Drummond GS, Baum J, Greenberg M, Lewis D, Abraham NG. Drummond GS, et al. Arch Biochem Biophys. 2019 Sep 30;673:108073. doi: 10.1016/j.abb.2019.108073. Epub 2019 Aug 16. Arch Biochem Biophys. 2019. PMID: 31425676 Free PMC article. Review.
In this review we examine the effects of both over- and under-production of heme oxygenase-1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular disease. In a few instances e.g., neonatal jaundice, overproduction of HO-1 and incre …
In this review we examine the effects of both over- and under-production of heme oxygenase-1 (HO-1) and HO activity on a broad …
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors.
Intagliata S, Salerno L, Ciaffaglione V, Leonardi C, Fallica AN, Carota G, Amata E, Marrazzo A, Pittalà V, Romeo G. Intagliata S, et al. Eur J Med Chem. 2019 Dec 1;183:111703. doi: 10.1016/j.ejmech.2019.111703. Epub 2019 Sep 17. Eur J Med Chem. 2019. PMID: 31550661 Review.
Among the different HO isoforms, HO-2 stands out for its neuroprotective properties and modulatory activity in male reproduction. ...To the best of our knowledge, among HO-2 inhibitors, clemizole derivatives are the most selective HO-2 inhibitors repor …
Among the different HO isoforms, HO-2 stands out for its neuroprotective properties and modulatory activity in male reproducti …
Constitutive HO-1 and CD55 (DAF) Expression and Regulatory Interaction in Cultured Podocytes.
Lianos EA, Wilson K, Goudevenou K, Detsika MG, Sharma M. Lianos EA, et al. Biomedicines. 2023 Dec 13;11(12):3297. doi: 10.3390/biomedicines11123297. Biomedicines. 2023. PMID: 38137516 Free PMC article.
In this preliminary study, we assessed whether constitutively expressed HO-1 regulates CD55 expression in cultured rat podocytes. We employed methods of flow cytometry, quantitative (q) RT-qPCR and post-transcriptional HO-1 gene silencing (HO-1 interfering RN …
In this preliminary study, we assessed whether constitutively expressed HO-1 regulates CD55 expression in cultured rat podocytes. We …
Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders.
Ryter SW. Ryter SW. Antioxidants (Basel). 2022 Mar 15;11(3):555. doi: 10.3390/antiox11030555. Antioxidants (Basel). 2022. PMID: 35326205 Free PMC article. Review.
HO activity is represented by two distinct isozymes, the inducible form, HO-1, and a constitutive form, HO-2, encoded by distinct genes (HMOX1, HMOX2, respectively). ...Strategies targeting the HO-1 pathway, including genetic or chemical modulation of …
HO activity is represented by two distinct isozymes, the inducible form, HO-1, and a constitutive form, HO-2, encoded b …
Upregulation of hemeoxygenase enzymes HO-1 and HO-2 following ischemia-reperfusion injury in connection with experimental cardiac arrest and cardiopulmonary resuscitation: Neuroprotective effects of methylene blue.
Wiklund L, Sharma A, Patnaik R, Muresanu DF, Sahib S, Tian ZR, Castellani RJ, Nozari A, Lafuente JV, Sharma HS. Wiklund L, et al. Prog Brain Res. 2021;265:317-375. doi: 10.1016/bs.pbr.2021.06.009. Epub 2021 Aug 12. Prog Brain Res. 2021. PMID: 34560924 Review.
Increased production of carbon monoxide (CO) by the enzyme hemeoxygenase (HO) in the brain is induced by the oxidative stress. HO is present in the CNS in two isoforms, namely the inducible HO-1 and the constitutive HO-2. Elevated levels of serum HO …
Increased production of carbon monoxide (CO) by the enzyme hemeoxygenase (HO) in the brain is induced by the oxidative stress. HO …
HO-1089 and HO-1197, Novel Herbal Formulas, Have Antitumor Effects via Suppression of PLK1 (Polo-like Kinase 1) Expression in Hepatocellular Carcinoma.
Song Y, Lee SY, Kim S, Choi I, Kim N, Park J, Seo HR. Song Y, et al. Cancers (Basel). 2023 Jan 30;15(3):851. doi: 10.3390/cancers15030851. Cancers (Basel). 2023. PMID: 36765811 Free PMC article.
Biological pathways involved in metabolism and the mitotic cell cycle were suppressed in HO-1089-treated HCC cells. HO-1089 attenuated expression of the G2/M phase regulatory protein, PLK1 (polo-like kinase 1), in HCC cells. ...The use of HO-1197, a novel her …
Biological pathways involved in metabolism and the mitotic cell cycle were suppressed in HO-1089-treated HCC cells. HO-1089 at …
HO-1/CO system in tumor growth, angiogenesis and metabolism - Targeting HO-1 as an anti-tumor therapy.
Loboda A, Jozkowicz A, Dulak J. Loboda A, et al. Vascul Pharmacol. 2015 Nov;74:11-22. doi: 10.1016/j.vph.2015.09.004. Epub 2015 Sep 25. Vascul Pharmacol. 2015. PMID: 26392237 Review.
Heme oxygenase-1 (HO-1, hmox-1) catalyzes the rate-limiting step in the heme degradation processes. ...The inhibition of HO-1 has been proposed as an anti-cancer therapy, however, because of non-specific effects of known HO-1 inhibitors, the discovery of idea …
Heme oxygenase-1 (HO-1, hmox-1) catalyzes the rate-limiting step in the heme degradation processes. ...The inhibition of HO-1 …
Synergistic Interaction Between Heme Oxygenase (HO) and Nuclear-Factor E2- Related Factor-2 (Nrf2) against Oxidative Stress in Cardiovascular Related Diseases.
Ndisang JF. Ndisang JF. Curr Pharm Des. 2017;23(10):1465-1470. doi: 10.2174/1381612823666170113153818. Curr Pharm Des. 2017. PMID: 28088909 Review.
Upon activation, Nrf2 translocates to the nucleus and binds to the antioxidant-response-element located at the promoter region of some anti-oxidants including the cytoprotective protein HO. Since the HO-1 gene harbors binding site for Nrf2, mutual stimulatory and re …
Upon activation, Nrf2 translocates to the nucleus and binds to the antioxidant-response-element located at the promoter region of some anti- …
Neutrophil and NETosis Modulation in Traumatic Heterotopic Ossification.
Nunez JH, Juan C, Sun Y, Hong J, Bancroft AC, Hwang C, Medrano JM, Huber AK, Tower RJ, Levi B. Nunez JH, et al. Ann Surg. 2023 Dec 1;278(6):e1289-e1298. doi: 10.1097/SLA.0000000000005940. Epub 2023 Jun 16. Ann Surg. 2023. PMID: 37325925
OBJECTIVE: To characterize the role of neutrophil extracellular traps (NETs) in heterotopic ossification (HO) formation and progression and to use mechanical and pharmacological methods to decrease NETosis and mitigate HO formation. ...We hypothesized that neutrophi …
OBJECTIVE: To characterize the role of neutrophil extracellular traps (NETs) in heterotopic ossification (HO) formation and progressi …
Comparison of Y-90 and Ho-166 Dosimetry Using Liver Phantom: A Monte Carlo Study7.
Yıldırım AK, Kökkülünk HT. Yıldırım AK, et al. Anticancer Agents Med Chem. 2022;22(7):1348-1353. doi: 10.2174/1871520621666210824111534. Anticancer Agents Med Chem. 2022. PMID: 34431467
The mean absorbed doses in tumor imitation were found to be 1.50E+031.36E+00 Gy and 4.58E+024.75E-01 Gy for Y-90 and Ho-166, respectively. And, the mean absorbed doses in normal parenchymal tissue were found to be2.07E+019.58E-02 Gy and 3.79E+002.63E-02 Gy for Y-90 and …
The mean absorbed doses in tumor imitation were found to be 1.50E+031.36E+00 Gy and 4.58E+024.75E-01 Gy for Y-90 and Ho-166, respecti …
146,798 results
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