Influence of Lipophilicity on the Antibacterial Activity of Polymyxin Derivatives and on Their Ability to Act as Potentiators of Rifampicin.
Brown P, Abdulle O, Boakes S, Divall N, Duperchy E, Ganeshwaran S, Lester R, Moss S, Rivers D, Simonovic M, Singh J, Stanway S, Wilson A, Dawson MJ.
Brown P, et al.
ACS Infect Dis. 2021 Apr 9;7(4):894-905. doi: 10.1021/acsinfecdis.0c00917. Epub 2021 Mar 10.
ACS Infect Dis. 2021.
PMID: 33688718
Free PMC article.
Here, we report the systematic investigation of the influence of lipophilicity on microbiological activity (including against strains with reduced susceptibility to polymyxins), potentiation of rifampicin, and in vitro toxicity within a series of next-generation polymyxin nonapep …
Here, we report the systematic investigation of the influence of lipophilicity on microbiological activity (including against strains with r …