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1991 1
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1999 3
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2001 1
2002 1
2003 1
2004 2
2006 2
2007 1
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63 results

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Page 1
Molecular foundations of prion strain diversity.
Carta M, Aguzzi A. Carta M, et al. Curr Opin Neurobiol. 2022 Feb;72:22-31. doi: 10.1016/j.conb.2021.07.010. Epub 2021 Jul 27. Curr Opin Neurobiol. 2022. PMID: 34416480 Free article. Review.
Strain diversity is determined by protein structure, post-translational modifications and the presence of extracellular matrix components, with single amino acid substitutions or altered protein glycosylation exerting dramatic effects. Here, we review recent advances in th …
Strain diversity is determined by protein structure, post-translational modifications and the presence of extracellular matrix components, w …
The biological function of the cellular prion protein: an update.
Wulf MA, Senatore A, Aguzzi A. Wulf MA, et al. BMC Biol. 2017 May 2;15(1):34. doi: 10.1186/s12915-017-0375-5. BMC Biol. 2017. PMID: 28464931 Free PMC article. Review.
Ablation of PrP(C) in mice results in well-defined structural and functional alterations in the peripheral nervous system. Many additional phenotypes were ascribed to the lack of PrP(C), but some of these were found to arise from genetic artifacts of the underlying mouse m …
Ablation of PrP(C) in mice results in well-defined structural and functional alterations in the peripheral nervous system. Many addit …
Established and Emerging Research Trends in Norway Lobster, Nephrops norvegicus.
Aguzzi J, Violino S, Costa C, Bahamon N, Navarro J, Chatzievangelou D, Robinson NJ, Doyle J, Martinelli M, Lordan C, Company JB. Aguzzi J, et al. Biology (Basel). 2023 Jan 31;12(2):225. doi: 10.3390/biology12020225. Biology (Basel). 2023. PMID: 36829502 Free PMC article. Review.
Taken together, the results indicate scarce knowledge on how burrowing behavior and its environmental control can alter stock assessment, because of the poor use of current and advanced monitoring technologies....
Taken together, the results indicate scarce knowledge on how burrowing behavior and its environmental control can alter stock assessm …
A conformational switch controlling the toxicity of the prion protein.
Frontzek K, Bardelli M, Senatore A, Henzi A, Reimann RR, Bedir S, Marino M, Hussain R, Jurt S, Meisl G, Pedotti M, Mazzola F, Siligardi G, Zerbe O, Losa M, Knowles T, Lakkaraju A, Zhu C, Schwarz P, Hornemann S, Holt MG, Simonelli L, Varani L, Aguzzi A. Frontzek K, et al. Nat Struct Mol Biol. 2022 Aug;29(8):831-840. doi: 10.1038/s41594-022-00814-7. Epub 2022 Aug 10. Nat Struct Mol Biol. 2022. PMID: 35948768 Free PMC article.
Here we show that toxic, prion-mimetic ligands induce an intramolecular R208-H140 hydrogen bond ('H-latch'), altering the flexibility of the alpha2-alpha3 and beta2-alpha2 loops of PrP(C). ...
Here we show that toxic, prion-mimetic ligands induce an intramolecular R208-H140 hydrogen bond ('H-latch'), altering the flexibility …
New and emerging roles of small RNAs in neurodegeneration, muscle, cardiovascular and inflammatory diseases.
Hruska-Plochan M, Li B, Kyburz D, Krützfeld J, Landmesser U, Aguzzi A, Polymenidou M. Hruska-Plochan M, et al. Swiss Med Wkly. 2015 Sep 16;145:w14192. doi: 10.4414/smw.2015.14192. eCollection 2015. Swiss Med Wkly. 2015. PMID: 26376442 Free article. Review.
Dysregulation of miRNAs has been confirmed in numerous diseases, and changes in their levels could play an essential role in disease onset and progression and could be used for prognosis and potential therapy. Indeed, disease-altered miRNAs may either signify a direct trig …
Dysregulation of miRNAs has been confirmed in numerous diseases, and changes in their levels could play an essential role in disease onset a …
Calreticulin mutations affect its chaperone function and perturb the glycoproteome.
Schürch PM, Malinovska L, Hleihil M, Losa M, Hofstetter MC, Wildschut MHE, Lysenko V, Lakkaraju AKK, Maat CA, Benke D, Aguzzi A, Wollscheid B, Picotti P, Theocharides APA. Schürch PM, et al. Cell Rep. 2022 Nov 22;41(8):111689. doi: 10.1016/j.celrep.2022.111689. Cell Rep. 2022. PMID: 36417879 Free article.
Especially glycoproteins are differentially expressed and undergo profound structural alterations in granulocytes and cell lines with homozygous, but not with heterozygous, CALR mutations. ...
Especially glycoproteins are differentially expressed and undergo profound structural alterations in granulocytes and cell lines with …
Genome-wide transcriptomics identifies an early preclinical signature of prion infection.
Sorce S, Nuvolone M, Russo G, Chincisan A, Heinzer D, Avar M, Pfammatter M, Schwarz P, Delic M, Müller M, Hornemann S, Sanoudou D, Scheckel C, Aguzzi A. Sorce S, et al. PLoS Pathog. 2020 Jun 29;16(6):e1008653. doi: 10.1371/journal.ppat.1008653. eCollection 2020 Jun. PLoS Pathog. 2020. PMID: 32598380 Free PMC article.
We constructed a searchable genome-wide atlas of mRNA abundance and splicing alterations during the course of disease in prion-inoculated mice. Prion infection induced PrP-dependent transient changes in mRNA abundance and processing already at eight weeks post inoculation, …
We constructed a searchable genome-wide atlas of mRNA abundance and splicing alterations during the course of disease in prion-inocul …
SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease.
Zhu C, Li B, Frontzek K, Liu Y, Aguzzi A. Zhu C, et al. J Exp Med. 2019 Apr 1;216(4):743-756. doi: 10.1084/jem.20171885. Epub 2019 Mar 6. J Exp Med. 2019. PMID: 30842236 Free PMC article.
This deleterious effect was not due to SARM1-dependent modulation of prion-induced neuroinflammation, since microglial activation, astrogliosis, and brain cytokine profiles were not altered by SARM1 deficiency. Whole-transcriptome analyses indicated that SARM1 deficiency l …
This deleterious effect was not due to SARM1-dependent modulation of prion-induced neuroinflammation, since microglial activation, astroglio …
Cystatin F is a biomarker of prion pathogenesis in mice.
Nuvolone M, Schmid N, Miele G, Sorce S, Moos R, Schori C, Beerli RR, Bauer M, Saudan P, Dietmeier K, Lachmann I, Linnebank M, Martin R, Kallweit U, Kana V, Rushing EJ, Budka H, Aguzzi A. Nuvolone M, et al. PLoS One. 2017 Feb 8;12(2):e0171923. doi: 10.1371/journal.pone.0171923. eCollection 2017. PLoS One. 2017. PMID: 28178353 Free PMC article.
63 results