Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis.
Jarvis JN, Lawrence DS, Meya DB, Kagimu E, Kasibante J, Mpoza E, Rutakingirwa MK, Ssebambulidde K, Tugume L, Rhein J, Boulware DR, Mwandumba HC, Moyo M, Mzinganjira H, Kanyama C, Hosseinipour MC, Chawinga C, Meintjes G, Schutz C, Comins K, Singh A, Muzoora C, Jjunju S, Nuwagira E, Mosepele M, Leeme T, Siamisang K, Ndhlovu CE, Hlupeni A, Mutata C, van Widenfelt E, Chen T, Wang D, Hope W, Boyer-Chammard T, Loyse A, Molloy SF, Youssouf N, Lortholary O, Lalloo DG, Jaffar S, Harrison TS; Ambition Study Group.
Jarvis JN, et al.
N Engl J Med. 2022 Mar 24;386(12):1109-1120. doi: 10.1056/NEJMoa2111904.
N Engl J Med. 2022.
PMID: 35320642
Free PMC article.
Clinical Trial.
Fungal clearance from cerebrospinal fluid was -0.40 log(10) colony-forming units (CFU) per milliliter per day in the liposomal amphotericin B group and -0.42 log(10) CFU per milliliter per day in the control group. Fewer participants had grade 3 or 4 adverse events in the …
Fungal clearance from cerebrospinal fluid was -0.40 log(10) colony-forming units (CFU) per milliliter per day in the liposomal amphotericin …