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Exacerbated innate host response to SARS-CoV in aged non-human primates.
Smits SL, de Lang A, van den Brand JM, Leijten LM, van IJcken WF, Eijkemans MJ, van Amerongen G, Kuiken T, Andeweg AC, Osterhaus AD, Haagmans BL. Smits SL, et al. PLoS Pathog. 2010 Feb 5;6(2):e1000756. doi: 10.1371/journal.ppat.1000756. PLoS Pathog. 2010. PMID: 20140198 Free PMC article.
The molecular pathways, however, that cause virus-induced ALI/ARDS in aged individuals are ill-defined. Here, we show that SARS-CoV-infected aged macaques develop more severe pathology than young adult animals, even though viral replication levels are similar. ...The anti- …
The molecular pathways, however, that cause virus-induced ALI/ARDS in aged individuals are ill-defined. Here, we show that SARS-CoV-i …
Distinct severe acute respiratory syndrome coronavirus-induced acute lung injury pathways in two different nonhuman primate species.
Smits SL, van den Brand JM, de Lang A, Leijten LM, van Ijcken WF, van Amerongen G, Osterhaus AD, Andeweg AC, Haagmans BL. Smits SL, et al. J Virol. 2011 May;85(9):4234-45. doi: 10.1128/JVI.02395-10. Epub 2011 Feb 16. J Virol. 2011. PMID: 21325418 Free PMC article.
Inflammatory cytokines, such as interleukin 1beta (IL-1beta), IL-8, and IL-6, play a major role in mediating and amplifying ALI/ARDS by stimulating chemotaxis and activation of neutrophils. To obtain further insight into the pathogenesis of SARS-CoV-associated ALI, …
Inflammatory cytokines, such as interleukin 1beta (IL-1beta), IL-8, and IL-6, play a major role in mediating and amplifying ALI/ARDS …