Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II.
Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P.
Rengachari S, et al.
Nat Struct Mol Biol. 2022 Dec;29(12):1159-1169. doi: 10.1038/s41594-022-00857-w. Epub 2022 Nov 24.
Nat Struct Mol Biol. 2022.
PMID: 36424526
Free PMC article.
The core of SNAPc binds two turns of DNA and recognizes the snRNA promoter-specific proximal sequence element (PSE), located upstream of the TATA box-binding protein TBP. Two extensions of SNAPc, called wing-1 and wing-2, bind TFIIA and TFIIB, respectively, explaining how …
The core of SNAPc binds two turns of DNA and recognizes the snRNA promoter-specific proximal sequence element (PSE), located upstream of the …