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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 3
1999 1
2000 3
2001 3
2002 4
2003 2
2004 5
2005 7
2006 6
2007 5
2008 21
2009 10
2010 11
2011 22
2012 21
2013 19
2014 26
2015 26
2016 25
2017 24
2018 44
2019 40
2020 52
2021 64
2022 90
2023 110
2024 48

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627 results

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Page 1
Artificial intelligence in drug design.
Zhong F, Xing J, Li X, Liu X, Fu Z, Xiong Z, Lu D, Wu X, Zhao J, Tan X, Li F, Luo X, Li Z, Chen K, Zheng M, Jiang H. Zhong F, et al. Sci China Life Sci. 2018 Oct;61(10):1191-1204. doi: 10.1007/s11427-018-9342-2. Epub 2018 Jul 18. Sci China Life Sci. 2018. PMID: 30054833 Review.
Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology, the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to spee …
Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology, the computer- …
Application of Computational Biology and Artificial Intelligence in Drug Design.
Zhang Y, Luo M, Wu P, Wu S, Lee TY, Bai C. Zhang Y, et al. Int J Mol Sci. 2022 Nov 5;23(21):13568. doi: 10.3390/ijms232113568. Int J Mol Sci. 2022. PMID: 36362355 Free PMC article. Review.
Booming computational approaches, including computational biology, computer-aided drug design, and artificial intelligence, have the potential to expedite the efficiency of drug discovery by minimizing the time and financial cost. ...The present review emphasizes on the ap …
Booming computational approaches, including computational biology, computer-aided drug design, and artificial intelligence, have the …
The Human Respiratory Microbiome: Current Understandings and Future Directions.
Zhao L, Luo JL, Ali MK, Spiekerkoetter E, Nicolls MR. Zhao L, et al. Am J Respir Cell Mol Biol. 2023 Mar;68(3):245-255. doi: 10.1165/rcmb.2022-0208TR. Am J Respir Cell Mol Biol. 2023. PMID: 36476129 Free PMC article.
Recent advances in amplicon and shotgun metagenomic sequencing technologies and data-analyzing methods have greatly aided the identification and characterization of microbial populations from airways. ...
Recent advances in amplicon and shotgun metagenomic sequencing technologies and data-analyzing methods have greatly aided the identif …
Computational drug discovery.
Ou-Yang SS, Lu JY, Kong XQ, Liang ZJ, Luo C, Jiang H. Ou-Yang SS, et al. Acta Pharmacol Sin. 2012 Sep;33(9):1131-40. doi: 10.1038/aps.2012.109. Epub 2012 Aug 27. Acta Pharmacol Sin. 2012. PMID: 22922346 Free PMC article. Review.
Computer-Aided Drug Design in Epigenetics.
Lu W, Zhang R, Jiang H, Zhang H, Luo C. Lu W, et al. Front Chem. 2018 Mar 12;6:57. doi: 10.3389/fchem.2018.00057. eCollection 2018. Front Chem. 2018. PMID: 29594101 Free PMC article. Review.
With rapid development of computational methodologies and high-performance computational resources, computer-aided drug design has emerged as a promising strategy to speed up epigenetic drug discovery. ...
With rapid development of computational methodologies and high-performance computational resources, computer-aided drug design has em …
Sonodynamic Therapy of NRP2 Monoclonal Antibody-Guided MOFs@COF Targeted Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis to Induce Autophagy-Dependent Ferroptosis.
Zhao Z, Wu Y, Liang X, Liu J, Luo Y, Zhang Y, Li T, Liu C, Luo X, Chen J, Wang Y, Wang S, Wu T, Zhang S, Yang D, Li W, Yan J, Ke Z, Luo F. Zhao Z, et al. Adv Sci (Weinh). 2023 Oct;10(30):e2303872. doi: 10.1002/advs.202303872. Epub 2023 Sep 3. Adv Sci (Weinh). 2023. PMID: 37661565 Free PMC article.
Therefore, microtubule-associated protein 1A/1B-light chain 3 (LC3) is activated, promoting lysosomal autophagy. This process also induces autophagy-dependent ferroptosis, aided by the upregulation of Nuclear Receptor Coactivator 4 (NCOA4). ...
Therefore, microtubule-associated protein 1A/1B-light chain 3 (LC3) is activated, promoting lysosomal autophagy. This process also induces a …
Ribosome-targeting antibacterial agents: Advances, challenges, and opportunities.
Zhang L, He J, Bai L, Ruan S, Yang T, Luo Y. Zhang L, et al. Med Res Rev. 2021 Jul;41(4):1855-1889. doi: 10.1002/med.21780. Epub 2021 Jan 27. Med Res Rev. 2021. PMID: 33501747 Review.
But not enough, the development of structural biology and new screening methods bring powerful tools, such as cryo-electron microscopy technology, advanced computer-aided drug design, and cell-free in vitro transcription/translation systems, for the discovery of novel ribo …
But not enough, the development of structural biology and new screening methods bring powerful tools, such as cryo-electron microscopy techn …
Machine Learning and Imaging Informatics in Oncology.
Tseng HH, Wei L, Cui S, Luo Y, Ten Haken RK, El Naqa I. Tseng HH, et al. Oncology. 2020;98(6):344-362. doi: 10.1159/000493575. Epub 2018 Nov 23. Oncology. 2020. PMID: 30472716 Free PMC article. Review.
In the era of personalized and precision medicine, informatics technologies utilizing machine learning (ML) and quantitative imaging are witnessing a rapidly increasing role in medicine in general and in oncology in particular. This expanding role ranges from computer-aided …
In the era of personalized and precision medicine, informatics technologies utilizing machine learning (ML) and quantitative imaging are wit …
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions.
Wang S, Wu W, Lin X, Zhang KM, Wu Q, Luo M, Zhou J. Wang S, et al. Cell Biosci. 2023 Dec 1;13(1):224. doi: 10.1186/s13578-023-01171-8. Cell Biosci. 2023. PMID: 38041134 Free PMC article. Review.
The emerging biomarkers discussed hold promise for future clinical application, aiding in the prevention of BCBM, improving the prognosis of patients, and guiding the implementation of personalized medicine....
The emerging biomarkers discussed hold promise for future clinical application, aiding in the prevention of BCBM, improving the progn …
Computer-Aided Directed Evolution Generates Novel AAV Variants with High Transduction Efficiency.
Han Z, Luo N, Wang F, Cai Y, Yang X, Feng W, Zhu Z, Wang J, Wu Y, Ye C, Lin K, Xu F. Han Z, et al. Viruses. 2023 Mar 26;15(4):848. doi: 10.3390/v15040848. Viruses. 2023. PMID: 37112829 Free PMC article.
Here, we targeted amino acid positions 442-469 of the VR-IV region and established an engineering paradigm of computer-aided directed evolution, based on training samples from previous datasets, to obtain a viral vector library with high diversity (~95,089). ...
Here, we targeted amino acid positions 442-469 of the VR-IV region and established an engineering paradigm of computer-aided directed …
627 results