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The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.
Dombernowsky SL, Samsøe-Petersen J, Petersen CH, Instrell R, Hedegaard AM, Thomas L, Atkins KM, Auclair S, Albrechtsen R, Mygind KJ, Fröhlich C, Howell M, Parker P, Thomas G, Kveiborg M. Dombernowsky SL, et al. Nat Commun. 2015 Jun 25;6:7518. doi: 10.1038/ncomms8518. Nat Commun. 2015. PMID: 26108729 Free PMC article.
PACS-2 co-localizes with ADAM17 on early endosomes and PACS-2 knockdown decreases the recycling and stability of internalized ADAM17. Hence, PACS-2 sustains ADAM17 cell-surface activity by diverting ADAM17 away from degradative pathways. ...
PACS-2 co-localizes with ADAM17 on early endosomes and PACS-2 knockdown decreases the recycling and stability of internalized
Blood transfusions and hip fracture mortality - A retrospective cohort study.
Greenhalgh MS, Gowers BTV, Iyengar KP, Adam RF. Greenhalgh MS, et al. J Clin Orthop Trauma. 2021 Jul 19;21:101506. doi: 10.1016/j.jcot.2021.101506. eCollection 2021 Oct. J Clin Orthop Trauma. 2021. PMID: 34367912 Free PMC article.
Data was collected from the national hip fracture database, electronic patient records and PACS. RESULTS: 75 patients received a blood transfusion. Receiving a blood transfusion increased absolute risk of one-year mortality by 2.466 (p < 0.05). ...
Data was collected from the national hip fracture database, electronic patient records and PACS. RESULTS: 75 patients received a bloo …
Implementation of a 24-Hour Teleradiology Service for Cruise Ships: A Pilot Study.
Henes FO, Stappenbeck P, Tahir E, Koehler A, Petutschnigg B, Adam G, Bannas P. Henes FO, et al. AJR Am J Roentgenol. 2020 Apr;214(4):754-760. doi: 10.2214/AJR.19.21794. Epub 2020 Jan 28. AJR Am J Roentgenol. 2020. PMID: 31990214
Radiographs and patient data were automatically integrated into the PACS and radiology information system of the radiology department at the hospital. ...
Radiographs and patient data were automatically integrated into the PACS and radiology information system of the radiology department …
Path Forward to Optimise Post-approval Change Management and Facilitate Continuous Supply of Medicines and Vaccines of High Quality Worldwide : Joint Position from EFPIA, IFPMA and Vaccines Europe.
Deavin A, Adam S, Ausborn S, Nielsen ASB, Cappellini S, Colmagne-Poulard I, Gastineau T, Gonzalez-Martinez A, Meillerais S, Mortazavi C. Deavin A, et al. Ther Innov Regul Sci. 2023 Jan;57(1):7-11. doi: 10.1007/s43441-022-00426-9. Epub 2022 Aug 2. Ther Innov Regul Sci. 2023. PMID: 35917091 Free PMC article.
Post-approval changes (PACs) to the registered information of authorised medicinal products are introduced routinely worldwide to enhance the robustness and efficiency of the manufacturing process, ensure timely supply in case of increased demand, improve quality control t …
Post-approval changes (PACs) to the registered information of authorised medicinal products are introduced routinely worldwide to enh …
Mitigation of indoor human exposure to airborne particles of outdoor origin in an urban environment during haze and non-haze periods.
Tran PTM, Adam MG, Balasubramanian R. Tran PTM, et al. J Hazard Mater. 2021 Feb 5;403:123555. doi: 10.1016/j.jhazmat.2020.123555. Epub 2020 Jul 29. J Hazard Mater. 2021. PMID: 33264848
The key objective of our study was to make a comparative evaluation of the effectiveness of portable air cleaners (PACs) and air conditioning (AC) systems equipped with particle filters in improving IAQ and to assess related long-term carcinogenic and non-carcinogenic heal …
The key objective of our study was to make a comparative evaluation of the effectiveness of portable air cleaners (PACs) and air cond …
Identification and genetic analysis of cancer cells with PCR-activated cell sorting.
Eastburn DJ, Sciambi A, Abate AR. Eastburn DJ, et al. Nucleic Acids Res. 2014;42(16):e128. doi: 10.1093/nar/gku606. Epub 2014 Jul 16. Nucleic Acids Res. 2014. PMID: 25030902 Free PMC article.
We introduce a new cell sorting technology that robustly sorts based on sequence-specific analysis of cellular nucleic acids. Our approach, PCR-activated cell sorting (PACS), uses TaqMan PCR to detect nucleic acids within single cells and trigger their sorting. ...PACS
We introduce a new cell sorting technology that robustly sorts based on sequence-specific analysis of cellular nucleic acids. Our approach, …
Quantitative PA tomography of high resolution 3-D images: Experimental validation in a tissue phantom.
Buchmann J, Kaplan B, Powell S, Prohaska S, Laufer J. Buchmann J, et al. Photoacoustics. 2020 Jan 8;17:100157. doi: 10.1016/j.pacs.2019.100157. eCollection 2020 Mar. Photoacoustics. 2020. PMID: 31956487 Free PMC article.
A calibrated absorber allowed scaling of the measured data during the inversion, while an acoustic correction method was employed to compensate the effects of limited view detection. Chromophore- and fluence-dependent step sizes and Adam optimization were implemented to ac …
A calibrated absorber allowed scaling of the measured data during the inversion, while an acoustic correction method was employed to compens …
Premature atrial contractions in the general population: frequency and risk factors.
Conen D, Adam M, Roche F, Barthelemy JC, Felber Dietrich D, Imboden M, Künzli N, von Eckardstein A, Regenass S, Hornemann T, Rochat T, Gaspoz JM, Probst-Hensch N, Carballo D. Conen D, et al. Circulation. 2012 Nov 6;126(19):2302-8. doi: 10.1161/CIRCULATIONAHA.112.112300. Epub 2012 Oct 9. Circulation. 2012. PMID: 23048073
BACKGROUND: Premature atrial contractions (PACs) are independent predictors of atrial fibrillation, stroke, and death. ...CONCLUSIONS: To our knowledge, this is the first study to assess risk factors for PAC frequency in the general population aged 50 years. PACs ar …
BACKGROUND: Premature atrial contractions (PACs) are independent predictors of atrial fibrillation, stroke, and death. ...CONCLUSIONS …
Picture archiving and communication systems lead to sustained improvements in reporting times and productivity: results of a 5-year audit.
Mackinnon AD, Billington RA, Adam EJ, Dundas DD, Patel U. Mackinnon AD, et al. Clin Radiol. 2008 Jul;63(7):796-804. doi: 10.1016/j.crad.2007.12.015. Epub 2008 Mar 25. Clin Radiol. 2008. PMID: 18555038
AIM: To evaluate the impact of picture archiving and communications systems (PACS) on reporting times and productivity in a large teaching hospital. ...Sustained improvements are felt to reflect the efficiencies and cultural change that accompanied the introduction of P
AIM: To evaluate the impact of picture archiving and communications systems (PACS) on reporting times and productivity in a large tea …
12 results