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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 3
1951 2
1952 1
1953 1
1954 2
1955 3
1956 5
1957 4
1958 6
1959 1
1961 2
1964 4
1965 3
1966 6
1967 12
1968 11
1969 15
1970 22
1971 24
1972 26
1973 30
1974 38
1975 101
1976 122
1977 114
1978 111
1979 116
1980 117
1981 114
1982 140
1983 205
1984 181
1985 251
1986 265
1987 271
1988 322
1989 461
1990 504
1991 497
1992 554
1993 612
1994 605
1995 718
1996 801
1997 831
1998 889
1999 882
2000 1002
2001 1093
2002 1168
2003 1378
2004 1536
2005 1761
2006 1880
2007 2009
2008 2157
2009 2446
2010 2526
2011 3076
2012 3371
2013 3570
2014 3792
2015 3900
2016 3934
2017 4052
2018 3988
2019 4138
2020 4147
2021 3465
2022 1864
2023 1686
2024 801

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66,472 results

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Page 1
Vitamin B1 (thiamine) and dementia.
Gibson GE, Hirsch JA, Fonzetti P, Jordan BD, Cirio RT, Elder J. Gibson GE, et al. Ann N Y Acad Sci. 2016 Mar;1367(1):21-30. doi: 10.1111/nyas.13031. Epub 2016 Mar 11. Ann N Y Acad Sci. 2016. PMID: 26971083 Free PMC article. Review.
In preclinical models, reduced thiamine can drive AD-like abnormalities, including memory deficits, neuritic plaques, and hyperphosphorylation of tau. Furthermore, excess thiamine diminishes AD-like pathologies. In addition to dietary deficits, drugs o …
In preclinical models, reduced thiamine can drive AD-like abnormalities, including memory deficits, neuritic plaques, and hype …
Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review.
Fang Z, Li L, Zhang H, Zhao J, Lu W, Chen W. Fang Z, et al. Front Immunol. 2021 Jul 14;12:720393. doi: 10.3389/fimmu.2021.720393. eCollection 2021. Front Immunol. 2021. PMID: 34335634 Free PMC article. Review.
Here we reviewed the gut microbial alteration in patients with AD, the association between gut microbiota, epidermal barrier, and toll-like receptors, and the interaction of probiotics and gut microbiota. ...This provides the supports for targeting gut microbiota to …
Here we reviewed the gut microbial alteration in patients with AD, the association between gut microbiota, epidermal barrier, and tol …
IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
Fu AK, Hung KW, Yuen MY, Zhou X, Mak DS, Chan IC, Cheung TH, Zhang B, Fu WY, Liew FY, Ip NY. Fu AK, et al. Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2705-13. doi: 10.1073/pnas.1604032113. Epub 2016 Apr 18. Proc Natl Acad Sci U S A. 2016. PMID: 27091974 Free PMC article.
Alzheimer's disease (AD) is a devastating condition with no known effective treatment. ...Collectively, our results demonstrate a potential therapeutic role for IL-33 in AD....
Alzheimer's disease (AD) is a devastating condition with no known effective treatment. ...Collectively, our results demonstrate a pot …
Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity.
Blundell J, Finlayson G, Axelsen M, Flint A, Gibbons C, Kvist T, Hjerpsted JB. Blundell J, et al. Diabetes Obes Metab. 2017 Sep;19(9):1242-1251. doi: 10.1111/dom.12932. Epub 2017 May 5. Diabetes Obes Metab. 2017. PMID: 28266779 Free PMC article. Clinical Trial.

RESULTS: After a standardised breakfast, semaglutide, compared with placebo, led to a lower ad libitum energy intake during lunch (-1255 kJ; P < .0001) and during the subsequent evening meal ( P = .0401) and snacks ( P = .0034), resulting in a 24% reduction in total ene

…
RESULTS: After a standardised breakfast, semaglutide, compared with placebo, led to a lower ad libitum energy intake during lunch (-1 …
A Mouse Model for Atopic Dermatitis Using Topical Application of Vitamin D3 or of Its Analog MC903.
Moosbrugger-Martinz V, Schmuth M, Dubrac S. Moosbrugger-Martinz V, et al. Methods Mol Biol. 2017;1559:91-106. doi: 10.1007/978-1-4939-6786-5_8. Methods Mol Biol. 2017. PMID: 28063040
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease with pruritus and high prevalence. ...In this chapter, we describe the induction and major features of MC903 and vitamin D3-induced AD-like inflammation in mice....
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease with pruritus and high prevalence. ...In this chapter, we des …
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model.
Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler RG, Zhang S, Abdelmohsen K, Bohr VA, Misra Sen J, Gorospe M, Mattson MP. Zhang P, et al. Nat Neurosci. 2019 May;22(5):719-728. doi: 10.1038/s41593-019-0372-9. Epub 2019 Apr 1. Nat Neurosci. 2019. PMID: 30936558 Free PMC article.
We found that, in the brains of patients with AD and in AD mouse models, Abeta plaque-associated Olig2- and NG2-expressing oligodendrocyte progenitor cells (OPCs), but not astrocytes, microglia, or oligodendrocytes, exhibit a senescence-like phenotype charact …
We found that, in the brains of patients with AD and in AD mouse models, Abeta plaque-associated Olig2- and NG2-expressing oli …
Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs.
Agrawal M, Saraf S, Saraf S, Antimisiaris SG, Chougule MB, Shoyele SA, Alexander A. Agrawal M, et al. J Control Release. 2018 Jul 10;281:139-177. doi: 10.1016/j.jconrel.2018.05.011. Epub 2018 May 24. J Control Release. 2018. PMID: 29772289 Review.
According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the year 2017 itself, the cost of AD treatment in the USA has been reported to rise to $259 billi …
According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is the 6th primary cause of death in the USA, which af …
Oral Administration of Resveratrol-Selenium-Peptide Nanocomposites Alleviates Alzheimer's Disease-like Pathogenesis by Inhibiting Abeta Aggregation and Regulating Gut Microbiota.
Li C, Wang N, Zheng G, Yang L. Li C, et al. ACS Appl Mater Interfaces. 2021 Oct 6;13(39):46406-46420. doi: 10.1021/acsami.1c14818. Epub 2021 Sep 27. ACS Appl Mater Interfaces. 2021. PMID: 34569225
Alzheimer's disease (AD) is a neurodegenerative disease associated with amyloid-beta (Abeta) deposition, leading to neurotoxicity (oxidative stress and neuroinflammation) and gut microbiota imbalance. ...Thus, we anticipate that Res-selenium-peptide nanocomposites will off …
Alzheimer's disease (AD) is a neurodegenerative disease associated with amyloid-beta (Abeta) deposition, leading to neurotoxicity (ox …
Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice.
Chen Y, Liang Z, Tian Z, Blanchard J, Dai CL, Chalbot S, Iqbal K, Liu F, Gong CX. Chen Y, et al. Mol Neurobiol. 2014 Feb;49(1):547-62. doi: 10.1007/s12035-013-8539-y. Epub 2013 Aug 31. Mol Neurobiol. 2014. PMID: 23996345 Free PMC article.
To investigate the role of metabolic insults in AD, we injected streptozotocin (STZ), a diabetogenic compound if used in the periphery, into the lateral ventricle of the 6-month-old 3xTg-AD mice and studied the cognitive function as well as AD-like bra …
To investigate the role of metabolic insults in AD, we injected streptozotocin (STZ), a diabetogenic compound if used in the peripher …
Depichering the Effects of Astragaloside IV on AD-Like Phenotypes: A Systematic and Experimental Investigation.
Wang X, Gao F, Xu W, Cao Y, Wang J, Zhu G. Wang X, et al. Oxid Med Cell Longev. 2021 Sep 24;2021:1020614. doi: 10.1155/2021/1020614. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34616501 Free PMC article.
Especially, the expression of PPARgamma, as well as BDNF, was also reduced in the hippocampus of AD-like mice. Conversely, AS-IV improved AbetaO infusion-induced memory impairment, inhibited neuronal loss and the phosphorylation of tau, and prevented the synaptic de …
Especially, the expression of PPARgamma, as well as BDNF, was also reduced in the hippocampus of AD-like mice. Conversely, AS- …
66,472 results
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