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HIV nucleoside reverse transcriptase inhibitors.
Amblard F, Patel D, Michailidis E, Coats SJ, Kasthuri M, Biteau N, Tber Z, Ehteshami M, Schinazi RF. Amblard F, et al. Eur J Med Chem. 2022 Oct 5;240:114554. doi: 10.1016/j.ejmech.2022.114554. Epub 2022 Jun 20. Eur J Med Chem. 2022. PMID: 35792384 Review.
This review discusses nucleoside reverse transcriptase inhibitors (NRTIs), including chain terminators, delayed chain terminators, nucleoside reverse transcriptase translocation inhibitors (NRTTIs), and nucleotide competing RT inhibitors (NcRTIs); focusing on their history, mecha …
This review discusses nucleoside reverse transcriptase inhibitors (NRTIs), including chain terminators, delayed chain terminators, nucleosid …
Platelet transfusion for patients with platelet dysfunction: effectiveness, mechanisms, and unanswered questions.
Lee RH, Kasthuri RS, Bergmeier W. Lee RH, et al. Curr Opin Hematol. 2020 Nov;27(6):378-385. doi: 10.1097/MOH.0000000000000608. Curr Opin Hematol. 2020. PMID: 32868672 Free PMC article. Review.
In patients on antiplatelet therapy, timing of transfusion and inhibitor mechanism-of-action are key in determining therapeutic success. SUMMARY: Expanding our understanding of the mechanisms by which transfused platelets exert their pro-hemostatic function in various blee …
In patients on antiplatelet therapy, timing of transfusion and inhibitor mechanism-of-action are key in determining therapeutic succe …
Molecular docking analysis of beta-caryophyllene with IRS-1, cSrc and Akt.
Mani V, Balraj M, Venktsan G, Soundrapandiyan J, Kasthuri R, Danavel A, Babu S. Mani V, et al. Bioinformation. 2021 Nov 30;17(11):916-920. doi: 10.6026/97320630017916. eCollection 2021. Bioinformation. 2021. PMID: 35655910 Free PMC article.
Diabetes mellitus (DM) is a common metabolic illness defined by hyperglycemia caused by insufficient production or absent of pancreatic insulin, with or without concomitant insulin action impairment. Hence, novel problem-solving approaches for assessing early metabolic dis …
Diabetes mellitus (DM) is a common metabolic illness defined by hyperglycemia caused by insufficient production or absent of pancreatic insu …
Effect of β-Caryophyllene on insulin resistance in skeletal muscle of high fat diet and fructose-induced type-2 diabetic rats.
Mani V, Badrachalam R, Shanmugam SN, Balraj M, Kasthuri R, Danavel A, Babu S. Mani V, et al. Bioinformation. 2021 Aug 31;17(8):741-747. doi: 10.6026/97320630017741. eCollection 2021. Bioinformation. 2021. PMID: 35540699 Free PMC article.
The use of oral hypoglycaemic drugs is limited due to its deleterious side effects and there is a need to find more efficacious agents for diabetes management. Hence, it is of interest to show the mechanism of action of beta-Caryophyllene on insulin signalling molecules in …
The use of oral hypoglycaemic drugs is limited due to its deleterious side effects and there is a need to find more efficacious agents for d …
Crystal structure of 3-({[(thio-phen-2-yl)methyl-idene]hydrazin-yl}carbon-yl)pyridinium chloride dihydrate.
Chandrasekaran T, Suresh M, Josephine Novina J, Syed Ali Padusha MK, Vasuki G, Kasthuri B. Chandrasekaran T, et al. Acta Crystallogr Sect E Struct Rep Online. 2014 Aug 6;70(Pt 9):o976-7. doi: 10.1107/S1600536814017565. eCollection 2014 Sep 1. Acta Crystallogr Sect E Struct Rep Online. 2014. PMID: 25309289 Free PMC article.
In the crystal, the organic cation, the chloride counter-anion and the two water mol-ecules of crystallization are linked through an intricate hydrogen-bonding network consisting of O-HO, O-HN, N-HCl, C-HCl, C-HO, N-HO, O-HCl and C-HS inter-actions that consolidate a three …
In the crystal, the organic cation, the chloride counter-anion and the two water mol-ecules of crystallization are linked through an intrica …