The rLVS deltacapB/iglABC vaccine provides potent protection in Fischer rats against inhalational tularemia caused by various virulent Francisella tularensis strains.
Mlynek KD, Cline CR, Biryukov SS, Toothman RG, Bachert BA, Klimko CP, Shoe JL, Hunter M, Hedrick ZM, Dankmeyer JL, Mou S, Fetterer DP, Qiu J, Lee ED, Cote CK, Jia Q, Horwitz MA, Bozue JA.
Mlynek KD, et al.
Hum Vaccin Immunother. 2023 Dec 15;19(3):2277083. doi: 10.1080/21645515.2023.2277083. Epub 2023 Nov 17.
Hum Vaccin Immunother. 2023.
PMID: 37975637
Free PMC article.
The rats were exposed to a high dose of aerosolized Type A strain Schu S4 (FRAN244), a Type B strain (FRAN255), or a tick derived Type A strain (FRAN254) and monitored for survival. ...Against the Type B strain, two doses of 10(7) CFU rLVS provided 100% protection, and a s …
The rats were exposed to a high dose of aerosolized Type A strain Schu S4 (FRAN244), a Type B strain (FRAN255), or a tick derived Typ …