The synthesis of dicationic extended bis-benzimidazoles

Zhijan Kang; Christine C Dykstra; David W Boykin

doi:10.3390/90300158

The synthesis of dicationic extended bis-benzimidazoles

Molecules. 2004 Feb 28;9(3):158-63. doi: 10.3390/90300158.

Authors

Zhijan Kang¹, Christine C Dykstra, David W Boykin

Affiliation

¹ Department of Chemistry Georgia State University, Atlanta, Georgia 30303, USA.

Abstract

The synthesis of extended dicationic bis-benzimidazoles starting from trans-1,2-bis(4-cyanophenyl)ethene and trans-1,2-bis(4-cyanophenyl)cyclopropane is reported. The target diamidines show significant in vitro activity against B. subtilis.

MeSH terms

Alkenes / chemical synthesis
Alkenes / chemistry*
Alkenes / pharmacology*
Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology*
Bacillus subtilis / drug effects*
Benzimidazoles / chemical synthesis
Benzimidazoles / chemistry
Benzimidazoles / pharmacology
Cyclopropanes / chemical synthesis
Cyclopropanes / chemistry*
Cyclopropanes / pharmacology*
Escherichia coli / drug effects
Nitriles / chemical synthesis
Nitriles / chemistry*
Nitriles / pharmacology*
Pentamidine / chemistry

Substances

Alkenes
Anti-Bacterial Agents
Benzimidazoles
Cyclopropanes
Nitriles
trans-1,2-bis(4-cyanophenyl)cyclopropane
trans-1,2-bis(4-cyanophenyl)ethene
bis-benzimidazole
Pentamidine