One-step synthesis of amphiphilic hyperbranched amylopectin derivatives, characterization and use as functional nanovehicles

Carbohydr Polym. 2013 Oct 15;98(1):905-13. doi: 10.1016/j.carbpol.2013.07.007. Epub 2013 Jul 9.

Abstract

Amylopectin is a naturally hyperbranched biopolymer with an extremely high molecular weight. Furthermore, this material is non-toxic in nature, and exhibits good biocompatibility and biodegradability properties. Herein, we describe the development of a one-step reaction strategy for the synthesis of amphiphilic high-molecular-weight hyperbranched amylopectin derivatives with hydrophobic shells and large hydrophilic cores. The chemical structures of the resulting materials were characterized using FTIR spectroscopy, solid-state (13)C cross-polarization/magic angle spinning NMR spectroscopy and gas chromatography. The results from transmission electron microscopy, fluorescence spectroscopy, and UV-vis analysis confirmed that the hyperbranched amylopectin derivatives were composed of hydrophobic shells with cholesteryl residues and hydrophilic amylopectin cores. These amylopectin derivatives exhibited high encapsulation capabilities toward water-soluble molecules, and could be used as functional nanovehicles for the controlled release of water-soluble molecules, and the in situ synthesis of metallic nanoparticles.

Keywords: Amylopectin; Controlled release; Hyperbranched polysaccharide; Metallic nanoparticle; Nanovehicle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amylopectin / analogs & derivatives*
  • Amylopectin / chemical synthesis*
  • Amylopectin / chemistry
  • Capsules
  • Chemistry Techniques, Synthetic
  • Delayed-Action Preparations
  • Drug Carriers / chemical synthesis*
  • Drug Carriers / chemistry*
  • Hydrophobic and Hydrophilic Interactions*
  • Hydroxides / chemistry
  • Metal Nanoparticles / chemistry
  • Molecular Weight
  • Nanostructures / chemistry*
  • Solubility
  • Water / chemistry

Substances

  • Capsules
  • Delayed-Action Preparations
  • Drug Carriers
  • Hydroxides
  • Water
  • Amylopectin
  • hydroxide ion