Anticancer effects of juglone in OVCAR-3 human ovarian carcinoma are facilitated through programmed cell death, endogenous ROS production, inhibition of cell migration and invasion and cell cycle arrest

J BUON. 2021 May-Jun;26(3):1188.

Abstract

The Editors of JBUON issue an Expression of Concern to 'Anticancer effects of juglone in OVCAR-3 human ovarian carcinoma are facilitated through programmed cell death, endogenous ROS production, inhibition of cell migration and invasion and cell cycle arrest', by Jun-Yu Shi, Zhe-Ren Huang, Hong-Yan Gao, Xiao-Li Xu; JBUON 2020;25(2):779-784; PMID: 32521867. Following the publication of the above article, readers drew to our attention that part of the data was possibly unreliable. We sent emails to the authors with a request to provide the raw data to prove the originality, but received no reply. Therefore, as we continue to work through the issues raised, we advise readers to interpret the information presented in the article with due caution. We thank the readers for bringing this matter to our attention. We apologize for any inconvenience it may cause.

Publication types

  • Expression of Concern

MeSH terms

  • Apoptosis*
  • Cell Cycle Checkpoints
  • Cell Line, Tumor
  • Cell Movement
  • Female
  • Humans
  • Naphthoquinones
  • Ovarian Neoplasms*
  • Reactive Oxygen Species

Substances

  • Naphthoquinones
  • Reactive Oxygen Species
  • juglone